Abstract: A computing device comprising a processor is configured to perform the techniques of this disclosure. The processor may duplicate a first node of a tree data structure to create a duplicate node, and create an inbound edge of the duplicate node to a parent node of the first node and an outbound edge to at least one child node of the first node. The processor may receive an update to the at least one child node of the first node. In response to determining that the at least one child node has multiple parent nodes, the processor may duplicate the at least one child node to create a duplicate child node, create an outbound edge of the duplicate node to the duplicate child node, delete the outbound edge of the duplicate node to the at least one child node, and perform the update to the at least one child node.

Abstract: A system and method for calculating an estimate of a body condition score (BCS) for a bovine animal is described. The system comprises a visual spectrum camera configured to collect visual spectrum data of the animal in an area of interest, an infra-red camera configured to collect near infra-red spectrum data of the animal related to soft tissue distribution around the area of interest, and one or more neural networks trained using a first training dataset comprising combined imaging data for each of a plurality of animals and corresponding BCS's for the plurality of animals, in which the combined imaging data for each animal comprises the visual spectrum data and the near infra-red spectrum data for the animal. The system also includes a processor configured to: receive the combined imaging data for the animal and apply the one or more neural networks to the combined imaging data for the animal to calculate an estimate of a BCS for the animal.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof at a dose of at least about 0.003 mg/kg to at least about 20 mg/kg.

Abstract: Techniques are disclosed for digitizing a framework for clinical development. In one example, A computing device comprising a memory configured to store a regulatory database, and one or more processors may be configured to perform the techniques. The one or more processors may retrieve, from the regulatory database, a template based on a governance process, receive, via a user interface, input from a user, parameterize the template based on the governance process with the user input to create a parameterized template, and store the parameterized template in a database.

Abstract: Techniques are disclosed for digitizing a framework for clinical development. In one example, a computing device comprising a memory configured to store a study and a processor may be configured to perform the techniques. The processor may receive, from a user, an input specifying a plurality of trial elements for the study, and receive, from the user, an input arranging the plurality of trial elements into a tree data structure. The processor may also determine, based on the tree data structure of the plurality of trial elements, one or more trial arms for the study, each trial arm of the one or more trial arms comprising a single path between at least one trial element of the plurality of trial elements to at least one other trial element of the plurality of trial elements. The processor may further output, for display, the one or more trial arms for the study.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: The invention provides improved anti-BCMA CAR T cell compositions for adoptive T cell therapy for relapsed/refractory multiple myeloma.

Abstract: The invention provides improved anti-BCMA CAR T cell compositions for adoptive T cell therapy for relapsed/refractory multiple myeloma.

Abstract: The invention provides improved anti-BCMA CAR T cell compositions for adoptive T cell therapy for relapsed/refractory multiple myeloma.

Abstract: The present disclosure relates to methods of treating cancer comprising administering to a subject an anti-IL-27 antibody, atezolizumab, and bevacizumab.

Abstract: The present disclosure relates to methods of treating cancer comprising administering to a subject an anti-IL-27 antibody and pembrolizumab.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: The invention provides methods and uses of treating cancer with and IgG4 anti-CD39_229p antibody in combination with pembrolizumab, wherein the IgG4 anti-CD39_229p antibody is provided at particular doses and dosages.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof at a dose of at least about 0.003 mg/kg to at least about 20 mg/kg.

Abstract: The invention provides methods of treating cancer using an anti-CD39 antibody or fragment thereof as monotherapy or in combination with other therapies at particular dosages and frequencies.

Abstract: A kit for preparing a nucleic acid sample for analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) is provided, the kit comprising: a lyophilized enzyme composition comprising: micrococcal nuclease; nuclease P1; and bacterial alkaline phosphatase (BAP); and a digestion buffer. Also provided are enzyme compositions and methods of use for rapid, efficient preparation of a nucleic acid sample for analysis by LC-MS/MS, without the need for denaturation of the sample.