Abstract: An improved anti-hypertensive agent, the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine dihydrate.

Abstract: High calorie solutions of low molecular weight glucose polymer mixtures useful for intravenous administration, preferably via a peripheral vein, are disclosed. Methods of preparing the solutions and their preferred rate of infusion at less than 5 mg./min./kg. of patient body weight are also disclosed. The solutions can be isotonic to human blood at 20-50% W/V as the glucose polymer mixtures have an average degree of polymerization ranging from 4 to 10. At the preferred rate of infusion high utilization of the glucose polymers infused occurs in human patients, including diabetics. The utilization can be further enhanced by concomitant injections of insulin. The solutions can be administered concomitantly with amino acids, lipid emulsions, vitamins and electrolytes.

Abstract: Excellent results have been obtained by reacting N-carboxyanhydrides of aminoacids with dopamine. This new route for making aminoacid derivatives of dopamine is advantageous as the aminoacid needs no blocking of the amino group and therefore no additional reaction step for the removal of such a blocking group.

Abstract: The present process describes a new and improved method for making the amides of an aminoacid. The new procedure involves only two steps, produces good yield and requires neither isolation nor purification of the intermediate. It also assures that the optical rotation of the starting material is not affected.