Patents by Inventor Robert Royal Graham

Robert Royal Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Method for Treating Complement-Associated Conditions
    Publication number: 20210207219
    Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 8, 2021
    Applicant: Genentech, Inc.
    Inventors: Brian Yaspan, Robert Royal Graham, Amy Dressen, Zhengrong Li, Erich Strauss, Teodorica Bugawan
  • Compositions and method for treating complement-associated conditions
    Patent number: 10947591
    Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: March 16, 2021
    Assignee: Genentech, Inc.
    Inventors: Brian Yaspan, Robert Royal Graham, Amy Dressen, Zhengrong Li, Erich Strauss, Teodorica Bugawan
  • COMPOSITIONS AND METHOD FOR TREATING COMPLEMENT-ASSOCIATED CONDITIONS
    Publication number: 20190185935
    Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
    Type: Application
    Filed: August 20, 2018
    Publication date: June 20, 2019
    Inventors: Brian YASPAN, Robert Royal GRAHAM, Amy DRESSEN, Zhengrong LI, Erich STRAUSS, Teodorica BUGAWAN
  • Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
    Patent number: 10093978
    Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: October 9, 2018
    Assignee: GENENTECH, INC.
    Inventors: Brian Yaspan, Robert Royal Graham, Amy Dressen, Zhengrong Li, Erich Strauss, Teodorica Bugawan
  • PREDICTING PROGRESSION TO ADVANCED AGE-RELATED MACULAR DEGENERATION USING A POLYGENIC SCORE
    Publication number: 20180163262
    Abstract: The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).
    Type: Application
    Filed: July 18, 2017
    Publication date: June 14, 2018
    Inventors: Timothy W. Behrens, Robert Royal Graham
  • COMPOSITIONS AND METHOD FOR TREATING COMPLIMENT-ASSOCIATED CONDITIONS
    Publication number: 20150044205
    Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
    Type: Application
    Filed: August 11, 2014
    Publication date: February 12, 2015
    Applicant: GENENTECH, INC.
    Inventors: Brian Yaspan, Robert Royal Graham, Amy Dressen, Zhengrong Li, Erich Strauss, Teodorica Bugawan
  • PREDICTING PROGRESSION TO ADVANCED AGE-RELATED MACULAR DEGENERATION USING A POLYGENIC SCORE
    Publication number: 20140286947
    Abstract: The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).
    Type: Application
    Filed: March 4, 2014
    Publication date: September 25, 2014
    Applicant: Genentech, Inc.
    Inventors: Timothy W. Behrens, Robert Royal Graham
  • Predicting progression to advanced age-related macular degeneration using a polygenic score
    Publication number: 20120107315
    Abstract: The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).
    Type: Application
    Filed: November 1, 2011
    Publication date: May 3, 2012
    Inventors: Timothy W. Behrens, Robert Royal Graham