Abstract: A method to improve the contractile function of the heart in myocarditis and other forms of heart failure is disclosed. The method consists essentially of administering a tetrapyrrole or metallotetrapyrrole which inhibits or reduces the endogenous guanylyl cyclase activity in cardiac myocyte of the patient.

Abstract: A kinetic reaction mixture is sampled continuously for determining the effect of a specific agent on the population density of a bio-organic molecule of interest as a function of time. A reaction sample containing the molecule of interest is processed through a high performance liquid chromatography column which produces longitudinal separation of a specific bio-organic molecule of interest. A continuous stream of longitudinally separated bio-organic molecules having a specific property of interest is delivered as a flowing stream into longitudinally separated sample receiving apertures formed in the face of a gel slab. Movement of the delivery nozzle and separation of the sample receiving apertures cause sample batches of reaction products to be deposited within separate channels, with the number of receiving channels corresponding generally with the number of discrete sample time intervals.