Patents by Inventor Robert S. DiPaola

Robert S. DiPaola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for cancer prevention and treatment derived from Inula britannica
    Publication number: 20040052881
    Abstract: Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom.
    Type: Application
    Filed: September 15, 2003
    Publication date: March 18, 2004
    Inventors: Chi-Tang Ho, Mohammed Rafi, Robert S. DiPaola, Geetha Ghai, Robert T. Rosen, Naisheng Bai
  • Inducing cell apoptosis and treating cancer using 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone
    Patent number: 6627623
    Abstract: Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom. The compounds of 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone are isolated and used for inducing apoptosis in cells and for treating cancer in an animal. Induction of apoptosis comprises contacting cells with a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation. Further, treatment of cancer in an animal comprises administering to an animal a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation to treat the cancer.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: September 30, 2003
    Assignee: Rutgers, the State University
    Inventors: Chi-Tang Ho, Mohammed Rafi, Robert S. Dipaola, Geetha Ghai, Robert T. Rosen, Naisheng Bai
  • Use of 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4?-hydroxyphenyl) as an anticarcinogenic agent
    Patent number: 6498195
    Abstract: Compositions and methods are provided for prevention and treatment of cancer. The compositions comprise pure hydroxylated chalcone compounds of licorice root (Glycyrrhiza glabra) including 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: December 24, 2002
    Assignees: Rutgers, The State University of New Jersey, University of Medicine and Dentistry of New Jersey
    Inventors: Robert T. Rosen, Chi-Tang Ho, Robert S. DiPaola, Mohamed M. Rafi, Bret C. Vastano, Geetha Ghai
  • Compositions and methods for cancer prevention and treatment derived from Inula britannica
    Publication number: 20020155178
    Abstract: Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom.
    Type: Application
    Filed: February 20, 2002
    Publication date: October 24, 2002
    Inventors: Chi-Tang Ho, Mohammed Rafi, Robert S. DiPaola, Geetha Ghai, Robert T. Rosen, Naisheng Bai
  • Anti-carcinogenic activity of hydroxylated chalcone compounds extracted from licorice root
    Publication number: 20020022665
    Abstract: Compositions and methods are provided for prevention and treatment of cancer. The compositions comprise pure hydroxylated chalcone compounds of licorice root (Glycyrrhiza glabra) including 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
    Type: Application
    Filed: June 13, 2001
    Publication date: February 21, 2002
    Inventors: Robert T. Rosen, Chi-Tang Ho, Robert S. DiPaola, Mohamed M. Rafi, Bret C. Vastano, Geetha Ghai