Patents by Inventor Robert S. Hattner

Robert S. Hattner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport
    Patent number: 5407658
    Abstract: Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically to glucose transport protein, and in doing so, serve as markers indicating the amount of glucose transport protein present on the surfaces of cells. The analogs differ from cytochalasin B by the inclusion of a radionuclide in the region of the terminal phenyl group on cytochalasin B, where the radionuclide does not interfere with the binding specificity of the analog. Disclosed herein are such analogs as well as analogs with which readily accept radionuclides at the desired location on the structure, either by conjugation or substitution.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: April 18, 1995
    Assignee: The Regents of the University of California
    Inventor: Robert S. Hattner
  • Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport
    Patent number: 5342926
    Abstract: Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically to glucose transport protein, and in doing so, serve as markers indicating the amount of glucose transport protein present on the surfaces of cells. The analogs differ from cytochalasin B by the inclusion of a radionuclide in the region of the terminal phenyl group on cytochalasin B, where the radionuclide does not interfere with the binding specificity of the analog. Disclosed herein are such analogs as well as analogs with which readily accept radionuclides at the desired location on the structure, either by conjugation or substitution.
    Type: Grant
    Filed: June 8, 1993
    Date of Patent: August 30, 1994
    Assignee: The Regents of the University of California
    Inventor: Robert S. Hattner
  • Contrast agents for nuclear magnetic resonance imaging
    Patent number: 4972837
    Abstract: A method is provided for obtaining in vivo differentiation of tissues in an animal by nuclear magnetic resonance imaging comprising the steps of introducing into the animal a complex comprising a paramagnetic metal ion and a chelator.
    Type: Grant
    Filed: September 16, 1987
    Date of Patent: November 27, 1990
    Assignee: Regents of the University of California
    Inventors: Barry L. Engelstad, Robert C. Brasch, Robert S. Hattner, George Wesbey, John P. Huberty
  • Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging
    Patent number: 4909257
    Abstract: A method is provided for obtaining in vivo diferentiation of tissues in an animal by nuclear magnetic resonance imaging comprising the steps of introducing into the animal a complex comprising a paramagnetic ferric ion and a chelator. Particular contrast agents, Fe(HBED) and Fe(EHPG), are excretable by a hepatobiliary pathway.
    Type: Grant
    Filed: April 28, 1989
    Date of Patent: March 20, 1990
    Assignee: The Regents of the University of California
    Inventors: Barry L. Engelstad, Robert C. Brasch, Robert S. Hattner, George Wesbey, John P. Huberty