Patents by Inventor Robert S. Hodges
Robert S. Hodges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8575170Abstract: Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells in vitro and inhibiting the growth of cancers in viva. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of lung, pancreatic and head and neck cancers.Type: GrantFiled: February 25, 2011Date of Patent: November 5, 2013Assignee: The Regents of the Unversity of Colorado, a body corporateInventors: Lajos Gera, Daniel C. Chan, Robert S. Hodges, Paul A. Bunn
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Patent number: 8563515Abstract: The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin.Type: GrantFiled: November 19, 2008Date of Patent: October 22, 2013Assignee: The Regents of the University of Colorado, a body corporateInventors: Margaret C. Neville, Neal Beeman, Robert S. Hodges
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Patent number: 8454977Abstract: The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: GrantFiled: July 8, 2011Date of Patent: June 4, 2013Assignee: The Regents of the University of Colorado, a Body CorporateInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Publication number: 20130035469Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, specificity, resistance to degradation desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides result from structure-based rational design relating to antimicrobial peptide V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Some peptides contain one or more (or all) amino acids in the D configuration.Type: ApplicationFiled: August 17, 2012Publication date: February 7, 2013Applicant: The Regents of the University of Colorado, a body corporateInventors: Robert S. Hodges, Yuxin Chen
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Publication number: 20130008268Abstract: A positioning apparatus converts linear movement along a first axis into either linear movement along another axis or rotational movement. The apparatus includes a fixed element and one or more moveable elements which are moveable relative to the fixed element. A first guide element is attached to the fixed element and a second guide element is attached to the moveable element. An adjustment mechanism, which is associated with the first and second guide elements, is moveable relative to the fixed element along a first axis, and movement of the adjustment causes movement of the moveable element.Type: ApplicationFiled: July 6, 2011Publication date: January 10, 2013Applicant: Siskiyou Design, Inc.Inventors: Robert B. Hodge, Robert S. Hodge
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Patent number: 8252737Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.Type: GrantFiled: December 15, 2005Date of Patent: August 28, 2012Assignee: The Regents of the University of ColoradoInventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
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Publication number: 20120014972Abstract: The disclosure relates at least in part to embodiments of compositions and methods including vaccines for protection against multiple serologically distinct strains of influenza virus. This disclosure provides significant advances and addresses important needs in the influenza vaccine field.Type: ApplicationFiled: January 26, 2011Publication date: January 19, 2012Inventors: Robert S. Hodges, Brooke Elizabeth Bishop Hirsch, Zhe Yan, Kathryn V. Holmes, Zhaohui Qian, Wendy Hartsock
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Publication number: 20120016102Abstract: The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: ApplicationFiled: July 8, 2011Publication date: January 19, 2012Applicants: UNIVERSITY OF ALBERTA, THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Publication number: 20120009212Abstract: Templated conjugates created from naturally-occurring protein sequences found in pathogens, such as viruses, are disclosed. The sequences are “templated” into a consensus coiled-coil sequence in order to form a two-stranded antigen suitable for immunization of a subject.Type: ApplicationFiled: January 26, 2011Publication date: January 12, 2012Inventors: Robert S. HODGES, Kathryn V. Holmes, Zhe Yan, Wendy J. Hartsock, Zhaohui Qian, Brooke Elizabeth Bishop Hirsch
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Publication number: 20110275648Abstract: Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells in vitro and inhibiting the growth of cancers in viva. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of lung, pancreatic and head and neck cancers.Type: ApplicationFiled: February 25, 2011Publication date: November 10, 2011Applicant: The Regents of the University of Colorado, a body corporateInventors: Lajos GERA, Daniel C. CHAN, Robert S. HODGES, Paul A. BUNN
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Publication number: 20110263511Abstract: The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin.Type: ApplicationFiled: November 19, 2008Publication date: October 27, 2011Inventors: Margaret C. Neville, Neal Beeman, Robert S. Hodges
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Patent number: 7976851Abstract: The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: GrantFiled: July 21, 2006Date of Patent: July 12, 2011Assignee: The Regents of the University of Colorado, A Body CorporateInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Publication number: 20110130344Abstract: The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin.Type: ApplicationFiled: February 9, 2011Publication date: June 2, 2011Applicant: The Regents of the University of Colorado, a body corporateInventors: Margaret C. Nerville, Robert S. Hodges, Neal Edward Beeman
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Publication number: 20110028386Abstract: Disclosed are antimicrobial peptides with useful or superior properties such as antimicrobial activity, desirable levels of hemolysis, and advantageous therapeutic index against various microorganisms, especially Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus. Also provided are methods of to control microbial growth and pharmaceutical compositions to treat or prevent microbial infections. Certain peptides are disclosed utilizing a structure-based rational modification of antimicrobial peptide D1, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face, or peptides with one or more amino acids in the D configuration, and peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation.Type: ApplicationFiled: June 3, 2010Publication date: February 3, 2011Inventors: ROBERT S. HODGES, ZIQING JIANG
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Publication number: 20100099614Abstract: Disclosed herein are antimicrobial peptides with useful and/or superior properties such as specificity, resistance to degradation, antimicrobial activity, desirably low levels of hemolytic activity, and a therapeutic index against a broad range of microorganisms including gram-negative, gram-positive and acid-fast bacteria, fungi and other organisms. Also provided are pharmaceutical compositions comprising these peptides and methods of using such peptides to control microbial growth or to treat or reduce incidence of infections caused by such microorganisms. Also disclosed are peptides at least one or all amino acids in the D configuration. Compositions disclosed herein are useful in the treatment of bacterial, mycobacterial and/or fungal infections or for reducing microbial cell numbers or growth on surfaces or in materials.Type: ApplicationFiled: October 6, 2009Publication date: April 22, 2010Inventors: Robert S. Hodges, Ziqing Jiang
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Publication number: 20090005300Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.Type: ApplicationFiled: December 15, 2005Publication date: January 1, 2009Applicants: The Regents of the University of Colorado, The University of British ColumbiaInventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
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Publication number: 20080287367Abstract: The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: ApplicationFiled: July 21, 2006Publication date: November 20, 2008Applicants: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, UNIVERSITY OF ALBERTAInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Publication number: 20080027006Abstract: The invention relates to diseases of coronaviruses, particularly severe acute respiratory syndrome (SARS). Compositions and methods in connection with peptide-based compounds are described relating to inhibition or prevention of coronavirus activity including that of SARS coronavirus and the ability of its S protein to achieve fusion with and entry into a target cell.Type: ApplicationFiled: February 14, 2005Publication date: January 31, 2008Applicant: The Regents of the University of ColoradoInventors: Brian Tripet, Robert S. Hodges
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Patent number: 7262272Abstract: The invention relates to the use of constrained coiled-coil polypeptides to mimic ?-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands which selectively bind the ?-helical segment contained in the native protein.Type: GrantFiled: February 15, 2005Date of Patent: August 28, 2007Assignee: The Governors of the University of AlbertaInventors: Leslie H. Kondejewski, Randall T. Irvin, Robert S. Hodges
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Patent number: 6872806Abstract: The invention relates to the use of constrained coiled-coil polypeptides to mimic ?-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands, which selectively bind the ?-helical segment contained in the native protein.Type: GrantFiled: June 26, 2000Date of Patent: March 29, 2005Assignee: The Governors of the University of AlbertaInventors: Leslie H. Kondejewski, Randall T. Irvin, Robert S. Hodges