Patents by Inventor Robert S. Jacobs

Robert S. Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10611780
    Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 7, 2020
    Assignee: Bill and Melinda Gates Foundation
    Inventors: Xianfeng Li, Christopher S. Lunde, Robert T. Jacobs, Vincent S. Hernandez, Yi Xia, Jacob J. Plattner, Kathy Jingyuan Cao, Yong-Kang Zhang, Matthew Perry
  • Patent number: 10611781
    Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 7, 2020
    Assignee: Bill and Melinda Gates Foundation
    Inventors: Xianfeng Li, Christopher S. Lunde, Robert T. Jacobs, Yasheen Zhou
  • Patent number: 10562921
    Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: February 18, 2020
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, David Scott Carter, Jason S. Halladay, Robert T. Jacobs, Yang Liu, Jacob J. Plattner, Yong-Kang Zhang, Michael John Witty
  • Publication number: 20200017531
    Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.
    Type: Application
    Filed: September 24, 2019
    Publication date: January 16, 2020
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu AKAMA, David Scott CARTER, Jason S. HALLADAY, Robert T. JACOBS, Yang LIU, Jacob J. PLATTNER, Yong-Kang ZHANG, Michael John WITTY
  • Publication number: 20190185493
    Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 20, 2019
    Inventors: Xianfeng Li, Christopher S. Lunde, Robert T. Jacobs, Yasheen Zhou
  • Patent number: 7074938
    Abstract: Disclosed herein are methods for synthesizing biologically active bis-heterocyclic compounds, e.g. bis-indoles. In particular, methods for making Soritin compounds such as Soritin B, bis-(1H-indol-3-yl)-acetic acid methyl ester, Soritin C, bis-2,2-(1-methyl-indol-3-yl) acetic acid methyl ester, Soritin D, bis-2,2-(1-methyl-indol-3-yl) acetic acid and Soritin compositions comprising the Soritin compounds are disclosed. Also disclosed are pharmaceutical formulations comprising the Soritin compounds and Soritin compositions.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: July 11, 2006
    Assignee: The Regents of the University of California
    Inventors: Robert S. Jacobs, R. Daniel Little
  • Patent number: 7060686
    Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: June 13, 2006
    Assignees: The Regents of the University of California, Florida Atlantic University Board of Trustees
    Inventors: Robert S. Jacobs, Russell G. Kerr
  • Patent number: 6787571
    Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: September 7, 2004
    Assignees: The Regents of the University of California, Florida Atlantic University Board of trustees
    Inventors: Robert S. Jacobs, Russell G. Kerr
  • Publication number: 20040147585
    Abstract: Disclosed herein are methods for synthesizing biologically active bis-heterocyclic compounds, e.g bis-indoles. In particular, methods for making Soritin compounds such as Soritin B, bis-(1H-indol-3-yl)-acetic acid methyl ester, Soritin C, bis-2,2-(1-methyl-indol-3-yl) acetic acid methyl ester, Soritin D, bis-2,2-(1-methyl-indol-3-yl) acetic acid and Soritin compositions comprising the Soritin compounds are disclosed. Also disclosed are pharmaceutical formulations comprising the Soritin compounds and Soritin compositions.
    Type: Application
    Filed: November 18, 2003
    Publication date: July 29, 2004
    Inventors: Robert S. Jacobs, R. Daniel Little
  • Patent number: 6660767
    Abstract: Compounds and compositions for stabilizing microtubules are disclosed. Also disclosed are methods of inhibiting, preventing, regulating, modulating, attenuating, stabilizing, or affecting microtubule formation or function. Methods of treating, preventing or inhibiting diseases and disorders associated with microtubule formation, function, or both by administering a microtubule stabilizing agent such as coumarin is also disclosed.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: December 9, 2003
    Assignee: The Regents of the University of California
    Inventors: Robert S. Jacobs, Leslie Wilson, Hamta Madari
  • Publication number: 20030171379
    Abstract: Disclosed herein are Mactanamide compounds having the following structural formula 1
    Type: Application
    Filed: December 24, 2002
    Publication date: September 11, 2003
    Inventors: Robert S. Jacobs, William H. Fenical, Paul R. Jensen, Peter Lorenz
  • Publication number: 20030166516
    Abstract: Disclosed herein are Exumolide compounds having the following structural formula 1
    Type: Application
    Filed: December 24, 2002
    Publication date: September 4, 2003
    Inventors: Robert S. Jacobs, William H. Fenical, Paul R. Jensen, Matthew Renner, Kelly M. Jenkins
  • Patent number: 6589957
    Abstract: The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed bis-heterocyclic compounds. Specifically exemplified herein are dragmacidin f, topsentin d, and topsentin e, and their salts, analogs, and derivatives.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: July 8, 2003
    Assignees: Harbor Branch Oceanographic Institution, Inc., Regents of the University of California
    Inventors: Amy E. Wright, Shirley A. Pomponi, Robert S. Jacobs
  • Patent number: 6589975
    Abstract: Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: July 8, 2003
    Assignees: The Regents of the University of California, Harbor Branch Oceanographic Inst.
    Inventors: Robert S. Jacobs, Claudia E. Moya, Amy E. Wright
  • Publication number: 20030104007
    Abstract: Disclosed herein are pseudopterosin compounds obtained from Symbiodinium spp. symbionts. Also disclosed are methods of obtaining, isolating, purifying or preparing at least one pseudopterosin compound comprising obtaining, isolating, purifying or preparing the pseudopterosin compound from at least one Symbiodinium spp. symbiont. In preferred embodiments, the host is Pseudopterogorgia, preferably, P. elisabethae. As disclosed, preferred pseudopterosin compounds and pseudopterosin compositions are of non-animal origin, substantially free of animal impurities, or both. Treatment methods using the pseudopterosin compounds and compositions are also disclosed.
    Type: Application
    Filed: October 4, 2002
    Publication date: June 5, 2003
    Inventors: Robert S. Jacobs, Laura Mydlarz, Russell G. Kerr
  • Publication number: 20030022815
    Abstract: Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.
    Type: Application
    Filed: August 5, 2002
    Publication date: January 30, 2003
    Applicant: Regents of the University of California
    Inventors: Robert S. Jacobs, Claudia E. Moya, Amy E. Wright
  • Publication number: 20030011619
    Abstract: A method and apparatus seamlessly blends multiple images. The multiple images are generated by independent processors, each processor producing a portion of the field of view from a defined viewpoint. Object polygons are introduced along the edges of each image that adjoin another of the images. Each of the polygons is assigned an opacity gradient which modulates the transparency of the polygon from fully transparent nearest the image center to fully opaque nearest the image edge. The images are projected with the polygons overlapping so that the images blend seamlessly together. A calibration apparatus is provided to minimize visual artifacts where the images overlap. Test patterns are projected and viewed with a video camera. The camera output is digitized and analyzed to adjust the polygon widths and opacity gradients until the overlap cannot be visually observed.
    Type: Application
    Filed: October 8, 1997
    Publication date: January 16, 2003
    Inventors: ROBERT S. JACOBS, JAMES L. DAVIS, WILLIAM M. PORADA, DAVID S. SAMSON
  • Patent number: 6495586
    Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: December 17, 2002
    Assignees: The Regents of the University of California, Oregon State University, GlaxoSmithKline
    Inventors: Robert S. Jacobs, Lisa A. Marshall, William H. Gerwick, Christopher Stevenson
  • Patent number: 6495588
    Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: December 17, 2002
    Assignees: The Regents of the University of California, State of Oregon c/o Oregon State University, GlaxoSmithKline
    Inventors: Robert S. Jacobs, Lisa A. Marshall, William H. Gerwick, Christopher Stevenson
  • Publication number: 20020151560
    Abstract: Compounds and compositions for stabilizing microtubules are disclosed. Also disclosed are methods of inhibiting, preventing, regulating, modulating, attenuating, stabilizing, or affecting microtubule formation or function. Methods of treating, preventing or inhibiting diseases and disorders associated with microtubule formation, function, or both by administering a microtubule stabilizing agent such as coumarin is also disclosed.
    Type: Application
    Filed: February 1, 2002
    Publication date: October 17, 2002
    Inventors: Robert S. Jacobs, Leslie Wilson, Hamta Madari