Patents by Inventor Robert S. Keynton
Robert S. Keynton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240260955Abstract: A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patient's tissue. The biodegradable clip remains in the patient's tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.Type: ApplicationFiled: April 18, 2024Publication date: August 8, 2024Applicant: University of Louisville Research Foundation, Inc.Inventors: Scott D. Cambron, Daniel S. Metzinger, Robert S. Keynton, Hares A. Patel, Dakota J. Waldecker
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Patent number: 11986176Abstract: A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patients tissue. The biodegradable clip remains in the patients tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.Type: GrantFiled: June 11, 2019Date of Patent: May 21, 2024Assignee: University of Louisville Research Foundation, Inc.Inventors: Scott D. Cambron, Daniel S. Metzinger, Robert S. Keynton, Hares A. Patel, Dakota J. Waldecker
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Patent number: 11691016Abstract: Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.Type: GrantFiled: April 19, 2019Date of Patent: July 4, 2023Assignee: University of Louisville Research Foundation, Inc.Inventors: Susan J. Harkema, Yangsheng Chen, Claudia Angeli, Douglas J. Jackson, Manikandan Ravi, John Naber, Robert S. Keynton, Thomas Roussel, Saliya Kirigeeganage
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Patent number: 11534064Abstract: Methods for automated segmentation system for retinal blood vessels from optical coherence tomography angiography images include a preprocessing stage, an initial segmentation stage, and a refining stage. Application of machine-learning techniques to segmented images allow for automated diagnosis of retinovascular diseases, such as diabetic retinopathy.Type: GrantFiled: June 20, 2018Date of Patent: December 27, 2022Assignees: University of Louisville Research Foundation, Inc., University of MassachusettsInventors: Ayman El-Baz, Nabila Eldawi, Shlomit Schaal, Mohammed Elmogy, Harpal Sandhu, Robert S. Keynton, Ahmed Soliman
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Patent number: 11481905Abstract: A method for segmentation of a 3-D medical image uses an adaptive patient-specific atlas and an appearance model for 3-D Optical Coherence Tomography (OCT) data. For segmentation of a medical image of a retina, In order to reconstruct the 3-D patient-specific retinal atlas, a 2-D slice of the 3-D image containing the macula mid-area is segmented first. A 2-D shape prior is built using a series of co-aligned training OCT images. The shape prior is then adapted to the first order appearance and second order spatial interaction MGRF model of the image data to be segmented. Once the macula mid-area is segmented into separate retinal layers this initial slice, the segmented layers' labels and their appearances are used to segment the adjacent slices. This step is iterated until the complete 3-D medical image is segmented.Type: GrantFiled: April 26, 2019Date of Patent: October 25, 2022Inventors: Ayman S. El-Baz, Ahmed Soliman, Ahmed Eltanboly, Ahmed Sleman, Robert S. Keynton, Harpal Sandhu, Andrew Switala
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Publication number: 20220254500Abstract: Computer-implemented systems and methods for automated diagnosis of diabetic retinopathy apply machine learning techniques to clinical and demographic data combined with optical coherence tomography and optical coherence tomography angiography image data to diagnose and grade diabetic retinopathy.Type: ApplicationFiled: September 4, 2020Publication date: August 11, 2022Inventors: AYMAN S. EL-BAZ, HARPAL SANDHU, ROBERT S. KEYNTON
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Publication number: 20220183973Abstract: Provided are methods, compositions, and kits that are useful for long-term stabilization of biospecimens at ambient and elevated temperatures that are resilient to degradation by environmental factors and contaminants In some embodiments, the presently disclosed subject matter can be employed for long-term storage of biospecimens that would typically require low and/or ultra-low storage conditions, but as a consequence of employing the presently disclosed compositions and/or methods, the need for cryo-and/or sub-zero refrigeration is not needed in order to get similar if not superior stability of the biospecimen.Type: ApplicationFiled: April 13, 2020Publication date: June 16, 2022Applicant: University of Louisville Research Foundation, Inc.Inventors: Gautam Gupta, Robert S. Keynton, Rajat Chauhan, Theodore Kalbfleisch
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Publication number: 20210228885Abstract: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.Type: ApplicationFiled: April 14, 2021Publication date: July 29, 2021Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Susan J. Harkema, Yangshen Chen, Robert S. Keynton, Douglas J. Jackson, John Naber, Thomas Roussel, Manikandan Ravi
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Publication number: 20210228884Abstract: Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.Type: ApplicationFiled: April 19, 2019Publication date: July 29, 2021Inventors: Susan J. Harkema, Yangsheng Chen, Claudia Angeli, Douglas J. Jackson, Manikandan Ravi, John Naber, Robert S. Keynton, Thomas Roussel, Saliya Kirigeeganage
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Publication number: 20210212673Abstract: A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patients tissue. The biodegradable clip remains in the patients tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.Type: ApplicationFiled: June 11, 2019Publication date: July 15, 2021Applicant: University of Louisville Research Foundation, Inc.Inventors: Scott D. Cambron, Daniel S. Metzinger, Robert S. Keynton, Hares A. Patel, Dakota J. Waldecker
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Patent number: 11007368Abstract: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.Type: GrantFiled: August 18, 2016Date of Patent: May 18, 2021Assignee: University of Louisville Research Foundation, Inc.Inventors: Susan J. Harkema, Yangshen Chen, Robert S. Keynton, Douglas J. Jackson, John Naber, Thomas Roussel, Manikandan Ravi
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Publication number: 20210082123Abstract: A method for segmentation of a 3-D medical image uses an adaptive patient-specific atlas and an appearance model for 3-D Optical Coherence Tomography (OCT) data. For segmentation of a medical image of a retina, In order to reconstruct the 3-D patient-specific retinal atlas, a 2-D slice of the 3-D image containing the macula mid-area is segmented first. A 2-D shape prior is built using a series of co-aligned training OCT images. The shape prior is then adapted to the first order appearance and second order spatial interaction MGRF model of the image data to be segmented. Once the macula mid-area is segmented into separate retinal layers this initial slice, the segmented layers' labels and their appearances are used to segment the adjacent slices. This step is iterated until the complete 3-D medical image is segmented.Type: ApplicationFiled: April 26, 2019Publication date: March 18, 2021Inventors: Ayman S. El-Baz, Ahmed Soliman, Ahmed Eltanboly, Ahmed Sleman, Robert S. Keynton, Harpal Sandhu, Andrew Switala
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Patent number: 10737095Abstract: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.Type: GrantFiled: March 29, 2018Date of Patent: August 11, 2020Assignee: Californina Institute of TechnologyInventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Jr., Yangsheng Chen
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Patent number: 10191009Abstract: Methods and sensing instruments are provided which perform automated electrochemical sensing and determination of metals in a liquid sample, such as drinking water or waste water. With use of microelectrode arrays, concentrations of metal are determined through a double potential step variation on anodic stripping coulometry, and the ability to generate these results provides for compact sensor networks that can be remotely deployed for determination of metals in samples, for real-time, decentralized sample monitoring.Type: GrantFiled: March 4, 2016Date of Patent: January 29, 2019Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Mohamed M. Marei, Richard P. Baldwin, Thomas J. Roussel, Jr., Robert S. Keynton
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Patent number: 10058818Abstract: Present embodiments provide an energy-efficient separator having at least two chambers fluidically isolated by a gas permeable membrane for the removal of dissolved gases from a sample which, in some aspects, enables cost-effective monitoring of liquid samples to be performed remotely and automatically, and in other aspects is suited for various other applications where removal and/or regulation of gases in a sample are desirable.Type: GrantFiled: May 27, 2015Date of Patent: August 28, 2018Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Mohamed M. Marei, Richard P. Baldwin, Thomas J. Roussel, Jr., Robert S. Keynton
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Publication number: 20180236241Abstract: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.Type: ApplicationFiled: August 18, 2016Publication date: August 23, 2018Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Susan J. Harkema, Yangshen Chen, Robert S. Keynton, Douglas J. Jackson, John Naber, Thomas Roussel, Manikandan Ravi
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Publication number: 20180229038Abstract: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.Type: ApplicationFiled: March 29, 2018Publication date: August 16, 2018Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, JR., Yangsheng Chen
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Patent number: 10022791Abstract: Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.Type: GrantFiled: November 13, 2015Date of Patent: July 17, 2018Assignee: University of Louisville Research Foundation, Inc.Inventors: Dhruvinkumar Patel, Kurtis James, Martin G. O'Toole, Robert S. Keynton
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Neurostimulator devices using a machine learning method implementing a gaussian process optimization
Patent number: 9931508Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.Type: GrantFiled: June 30, 2016Date of Patent: April 3, 2018Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEURORECOVERY TECHNOLOGIES, INC.Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangsheng Chen -
Publication number: 20170216068Abstract: The present invention relates to devices, systems and methods for implanting a radially expandable endoluminal stent. In certain aspects, the devices, systems, and methods of the present invention include a radially expandable endoluminal stent mounted on a delivery tube and having a distal end and a proximal end. A first retention element is also mounted on the delivery tube at or adjacent to the distal end of the expandable endoluminal device, and a second retention element is mounted on the delivery tube at or adjacent to the proximal end of the expandable endoluminal device. Expansion of the first and/or second retention elements reduces or prevents migration of the stent during and immediately after stent deployment.Type: ApplicationFiled: August 5, 2015Publication date: August 3, 2017Inventors: Amy C. Dwyer, Alex Isham, Scott D. Cambron, Robert S. Keynton