Patents by Inventor Robert S. Keynton

Robert S. Keynton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10191009
    Abstract: Methods and sensing instruments are provided which perform automated electrochemical sensing and determination of metals in a liquid sample, such as drinking water or waste water. With use of microelectrode arrays, concentrations of metal are determined through a double potential step variation on anodic stripping coulometry, and the ability to generate these results provides for compact sensor networks that can be remotely deployed for determination of metals in samples, for real-time, decentralized sample monitoring.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: January 29, 2019
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Mohamed M. Marei, Richard P. Baldwin, Thomas J. Roussel, Jr., Robert S. Keynton
  • Patent number: 10058818
    Abstract: Present embodiments provide an energy-efficient separator having at least two chambers fluidically isolated by a gas permeable membrane for the removal of dissolved gases from a sample which, in some aspects, enables cost-effective monitoring of liquid samples to be performed remotely and automatically, and in other aspects is suited for various other applications where removal and/or regulation of gases in a sample are desirable.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: August 28, 2018
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Mohamed M. Marei, Richard P. Baldwin, Thomas J. Roussel, Jr., Robert S. Keynton
  • Publication number: 20180236241
    Abstract: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.
    Type: Application
    Filed: August 18, 2016
    Publication date: August 23, 2018
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Susan J. Harkema, Yangshen Chen, Robert S. Keynton, Douglas J. Jackson, John Naber, Thomas Roussel, Manikandan Ravi
  • Publication number: 20180229038
    Abstract: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
    Type: Application
    Filed: March 29, 2018
    Publication date: August 16, 2018
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, JR., Yangsheng Chen
  • Patent number: 10022791
    Abstract: Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: July 17, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Dhruvinkumar Patel, Kurtis James, Martin G. O'Toole, Robert S. Keynton
  • Patent number: 9931508
    Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 3, 2018
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEURORECOVERY TECHNOLOGIES, INC.
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangsheng Chen
  • Publication number: 20170216068
    Abstract: The present invention relates to devices, systems and methods for implanting a radially expandable endoluminal stent. In certain aspects, the devices, systems, and methods of the present invention include a radially expandable endoluminal stent mounted on a delivery tube and having a distal end and a proximal end. A first retention element is also mounted on the delivery tube at or adjacent to the distal end of the expandable endoluminal device, and a second retention element is mounted on the delivery tube at or adjacent to the proximal end of the expandable endoluminal device. Expansion of the first and/or second retention elements reduces or prevents migration of the stent during and immediately after stent deployment.
    Type: Application
    Filed: August 5, 2015
    Publication date: August 3, 2017
    Inventors: Amy C. Dwyer, Alex Isham, Scott D. Cambron, Robert S. Keynton
  • Publication number: 20160310739
    Abstract: Neurostimulator devices and methods of using these devices are described. The neurostimulator devices can include a stimulation assembly connectable to a plurality of electrodes; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern.
    Type: Application
    Filed: June 30, 2016
    Publication date: October 27, 2016
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangsheng Chen
  • Patent number: 9463019
    Abstract: Embodiments of this invention relate to trocar site closures including a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Embodiments of this invention also relate to an insertion device used to insert the closure into the wound and at least partially close the wound.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: October 11, 2016
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Daniel S. Metzinger, Robert S. Keynton, Scott D. Cambron
  • Publication number: 20160258900
    Abstract: Methods and sensing instruments are provided which perform automated electrochemical sensing and determination of metals in a liquid sample, such as drinking water or waste water. With use of microelectrode arrays, concentrations of metal are determined through a double potential step variation on anodic stripping coulometry, and the ability to generate these results provides for compact sensor networks that can be remotely deployed for determination of metals in samples, for real-time, decentralized sample monitoring.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 8, 2016
    Inventors: Mohamed M. Marei, Richard P. Baldwin, Thomas J. Roussel, JR., Robert S. Keynton
  • Patent number: 9409023
    Abstract: Described are devices including stimulation assemblies connectable to a plurality of electrodes. The plurality of electrodes can be configured to connect to a spinal cord at a location below a lesion of the spinal cord. The stimulation assembly can be configured to deliver stimulation to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes when located below the lesion of the spinal cord. Methods of using the devices are also described.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: August 9, 2016
    Assignees: California Institute of Technology, University of Louisville Research Foundation, Inc., The Regents of the University of California
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangshen Chen
  • Publication number: 20160067777
    Abstract: Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Dhruvinkumar Patel, Kurtis James, Martin G. O'Toole, Robert S. Keynton
  • Publication number: 20150343372
    Abstract: Present embodiments provide an energy-efficient separator having at least two chambers fluidically isolated by a gas permeable membrane for the removal of dissolved gases from a sample which, in some aspects, enables cost-effective monitoring of liquid samples to be performed remotely and automatically, and in other aspects is suited for various other applications where removal and/or regulation of gases in a sample are desirable.
    Type: Application
    Filed: May 27, 2015
    Publication date: December 3, 2015
    Inventors: MOHAMED M. MAREI, RICHARD P. BALDWIN, THOMAS J. ROUSSEL, JR., ROBERT S. KEYNTON
  • Publication number: 20150231396
    Abstract: A neurostimulator devices and systems for use with groups of electrodes placed within a subject's body. The devices and systems can include training devices and/or pulse generation systems.
    Type: Application
    Filed: January 23, 2015
    Publication date: August 20, 2015
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Johnathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca
  • Publication number: 20140343603
    Abstract: Disclosed herein are trocar site closures, comprising a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Also disclosed herein is an insertion device used to insert the closure into the wound and at least partially close the wound.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 20, 2014
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Daniel S. Metzinger, Robert S. Keynton, Scott D. Cambron
  • Publication number: 20140180361
    Abstract: A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.
    Type: Application
    Filed: March 26, 2012
    Publication date: June 26, 2014
    Applicants: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Johnathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchruch, Douglas J. Jackson, Nicholas A. Terrafranca, JR.
  • Patent number: 8569691
    Abstract: An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: October 29, 2013
    Assignee: University of Louisville Research Foundation
    Inventors: Scott Cambron, Thomas J. Roussel, Robert S. Keynton
  • Patent number: 8298392
    Abstract: The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: October 30, 2012
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Rathissh Dorairaj, Robert S. Keynton, Thomas J. Roussel, Jr., Carolyn M. Klinge, Wasana Sumanasekera, Gamini Sumanasekera
  • Publication number: 20120132798
    Abstract: An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.
    Type: Application
    Filed: November 23, 2010
    Publication date: May 31, 2012
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Scott Cambron, Thomas J. Roussel, Robert S. Keynton
  • Patent number: 7988839
    Abstract: An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: August 2, 2011
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Rathissh Dorairaj, Robert S. Keynton, Thomas J. Roussel, Mark M. Crain, Douglas J. Jackson, Kevin M. Walsh, John F. Naber, Richard P. Baldwin, Danielle B. Franco