Patents by Inventor Robert S. Kieval
Robert S. Kieval has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200114153Abstract: Devices, systems, and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: ApplicationFiled: August 22, 2019Publication date: April 16, 2020Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Publication number: 20170001013Abstract: Devices, systems, and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: ApplicationFiled: July 29, 2016Publication date: January 5, 2017Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Patent number: 9427583Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: GrantFiled: April 30, 2015Date of Patent: August 30, 2016Assignee: CVRx, Inc.Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Patent number: 9414760Abstract: Physiological parameters of a patient can be used to monitor patient status and/or in conjunction with patient therapy. Physiological cycles may be monitored by implanting a monitoring system into the patient, the system including an implantable pulse generator operably connected to a lead implanted on a carotid sinus of the patient, measuring at least one signal indicative of a physiological parameter of the patient along at least two vectors selected from: a first vector defined between a first electrode of the lead and a second electrode of the lead, a second vector defined between the first electrode of the lead and an electrode integrated into an implantable pulse generator, and a third vector defined between the second electrode of the lead and the electrode integrated into the implantable pulse generator, and providing an output indicative of the at least one signal indicative of the physiological parameter.Type: GrantFiled: January 10, 2014Date of Patent: August 16, 2016Assignee: CVRx, Inc.Inventor: Robert S. Kieval
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Patent number: 9199082Abstract: Devices and methods are provided for selecting a location to implant an electrode as part of a baroreflex activation therapy system. Images of a target blood vessel may be obtained with an imaging device, and the image used as part of or in conjunction with a patient-response-mapping procedure to determine a favorable location on the blood vessel to implant the electrode. Alternately, temperature measurements may be taken of a target vessel and utilized as part of or in conjunction with a patient-response-mapping procedure to determine a favorable location on the blood vessel to implant the electrode.Type: GrantFiled: July 27, 2012Date of Patent: December 1, 2015Assignee: CVRx, Inc.Inventors: Nadim Yared, Robert S. Kieval, Adam Cates
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Publication number: 20150238763Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: ApplicationFiled: April 30, 2015Publication date: August 27, 2015Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Patent number: 9044609Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: GrantFiled: November 18, 2011Date of Patent: June 2, 2015Assignee: CVRx, Inc.Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Patent number: 8880190Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: GrantFiled: November 30, 2012Date of Patent: November 4, 2014Assignee: CVRx, Inc.Inventors: Robert S Kieval, Peter T Keith, Matthew Burns, Thomas Hektner
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Patent number: 8838246Abstract: Devices, systems and methods are described which control blood pressure, nervous system activity, and neurohormonal activity by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces excessive blood pressure, sympathetic nervous system activity and neurohormonal activity, thereby minimizing their deleterious effects on a heart, vasculature and other organs and tissues. A baroreceptor activation device is positioned near a low-pressure baroreceptor, preferably in the venous system, heart, or pulmonary vasculature.Type: GrantFiled: September 27, 2006Date of Patent: September 16, 2014Assignee: CVRx, Inc.Inventor: Robert S. Kieval
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Patent number: 8755907Abstract: Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.Type: GrantFiled: May 21, 2013Date of Patent: June 17, 2014Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Martin A. Rossing
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Publication number: 20140128708Abstract: Physiological parameters of a patient can be used to monitor patient status and/or in conjunction with patient therapy. Physiological cycles may be monitored by implanting a monitoring system into the patient, the system including an implantable pulse generator operably connected to a lead implanted on a carotid sinus of the patient, measuring at least one signal indicative of a physiological parameter of the patient along at least two vectors selected from: a first vector defined between a first electrode of the lead and a second electrode of the lead, a second vector defined between the first electrode of the lead and an electrode integrated into an implantable pulse generator, and a third vector defined between the second electrode of the lead and the electrode integrated into the implantable pulse generator, and providing an output indicative of the at least one signal indicative of the physiological parameter.Type: ApplicationFiled: January 10, 2014Publication date: May 8, 2014Inventor: Robert S. Kieval
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Patent number: 8718789Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: GrantFiled: April 19, 2010Date of Patent: May 6, 2014Assignee: CVRx, Inc.Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Publication number: 20140121556Abstract: A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.Type: ApplicationFiled: October 28, 2013Publication date: May 1, 2014Inventors: Russell Eugene Anderson, Nadim Yared, John Charles Stroebel, Robert S. Kieval, Steve Check, Eric Lovett
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Patent number: 8712531Abstract: A system for providing baroreflex stimulation comprises a sensor to detect a parameter and provide a signal indicative of the parameter and a baroreflex stimulator. The baroreflex stimulator includes a driver to provide a control signal adapted to deliver a baroreflex therapy and a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.Type: GrantFiled: May 24, 2012Date of Patent: April 29, 2014Assignee: CVRx, Inc.Inventors: Robert S Kieval, Matthew M Burns, David J Serdar
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Patent number: 8620422Abstract: A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.Type: GrantFiled: September 27, 2007Date of Patent: December 31, 2013Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Martin Rossing, Adam Cates, Alejandro Covalin
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Patent number: 8606359Abstract: The present invention comprises a medical device having a baroreflex stimulator to generate a stimulation signal, the stimulation signal being adapted to stimulate a baroreflex, and a controller to communicate with the baroreflex stimulator and implement a baroreflex stimulus regimen to vary an intensity of the baroreflex stimulation provided by the stimulation signal to maintain stimulation efficacy.Type: GrantFiled: April 13, 2007Date of Patent: December 10, 2013Assignee: CVRx, Inc.Inventors: Martin A. Rossing, Robert S. Kieval, David J. Serdar, Bruce J. Persson
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Patent number: 8594794Abstract: The present invention provides systems, devices, and methods for using the same for activating (stimulating) the baroreflex system of a patient using a baroreflex activation system with incrementally changing therapy intensity by sensing/monitoring/interpreting sensed data.Type: GrantFiled: July 17, 2008Date of Patent: November 26, 2013Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Eric Grant Lovett, Alejandro Covalin
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Patent number: 8583236Abstract: Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. An intravascularly implantable medical device may include a sleeve formed at least in part of an expandable member configured to be movably attachable about at least a portion of an outer surface of an expandable intravascular stent, and one or more electrodes disposed on the sleeve and coupled to a control system and configured to selectively activate baroreceptors within a wall of a vessel when the expandable intravascular stent is implanted within the vessel.Type: GrantFiled: March 8, 2010Date of Patent: November 12, 2013Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Martin A. Rossing
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Patent number: 8571664Abstract: A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.Type: GrantFiled: November 20, 2012Date of Patent: October 29, 2013Assignee: CVRx, Inc.Inventors: Russell Eugene Anderson, Nadim Yared, John Charles Stroebel, Robert S Kieval, Steve Check, Eric Lovett
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Patent number: 8560076Abstract: Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.Type: GrantFiled: November 5, 2010Date of Patent: October 15, 2013Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Martin Rossing