Patents by Inventor Robert S. Ledley
Robert S. Ledley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030076585Abstract: This invention discloses an optical system for enhancing the image from a microscope's high power objective lens that permits the simultaneous viewing of an object at both high and low magnifications through a single high power objective lens. This is accomplished by the mounting of high and low power lens train tubes on a microscope body and by directing a light source through a microscope's high power objective lens, then through beam splitters and then through said high and low power lens train tubes.Type: ApplicationFiled: August 6, 2002Publication date: April 24, 2003Inventor: Robert S. Ledley
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Patent number: 5922282Abstract: Very rapid diagnosis and sensitivity testing can significantly stem the growing Tuberculosis epidemic in the United States, caused by susceptible AIDs patients and the occurrence of antibiotic resistant mycobacilli. Thus I have invented an automated computerized microscope, the ATBD unit, and slide module to diagnose and test patient's sputum by examining individual living mycobacteria from the patient sample with no culturing required. The diagnosis and sensitivity testing is accomplished in minutes or hours, instead of the current weeks to months. The system inserts a plasmid, specific for M. tuberculosis, carrying the luciferase gene into the mycobacteria by improved electroporesis on the slide. Luminescence indicates tuberculosis. Then the mycobacteria are bathed in antibiotics, and if the luminescence is not turned off, the patient's bacteria are resistant. A phage carrying the luciferase gene can also be used to infect the M.TB.Type: GrantFiled: June 7, 1995Date of Patent: July 13, 1999Inventor: Robert S. Ledley
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Patent number: 5335683Abstract: A non-slip support shoe for attachment to the end of any crutch or other walking aid comprises an attachment cylinder for attaching the shoe to the bottom of the crutch or walking aid; a pair of strip leaf springs, at least one of which is connected to the attachment cylinder; and a rubber sole provided on the bottom surface of a lower one of the strip leaf springs. In operation, when the maximum weight of a body is exerted on the crutch or walking aid, the strip leaf springs change configuration (i.e., flatten) so that the entire sole located on the lower strip leaf spring contacts the ground, thereby preventing slippage during use of the crutch or walking aid. Once the maximum weight of the body is removed, the strip leaf springs return to their original configuration so as not to interfere with the angled forward and backward positions of the crutch during use.Type: GrantFiled: June 3, 1993Date of Patent: August 9, 1994Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 5296846Abstract: A cursor control device for use with a three-dimensional stereoscopic image display system comprises a housing defining a volume corresponding to a displayed three-dimensional volume, and a joystick operable by the user for moving and positioning a cursor in the displayed three-dimensional volume. The joystick has a knob which is movable within the volume defined by the housing so as to designate desired positioning and movement of the cursor within the displayed three-dimensional volume. There is, at any given time, both positional and movement congruency between the position and movement of the knob and position and movement, respectively, of the cursor.Type: GrantFiled: October 5, 1992Date of Patent: March 22, 1994Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 5172988Abstract: The invention provides the user with the capability of viewing a form positioned in a printer associated with a computer, a keyboard and a monitor. The printer has a camera and a lens positioned thereon, the camera including an image sensing array for providing video signals corresponding to images sensed on the form. The computer processes the video signals to display images sensed on various portions of the form. The user responds by entering via a keyboard data corresponding to the various portions of the form displayed. During the first use of a form, the computer memorizes the portions of the form for which data are entered and on which data are to be printed. For subsequent uses of the form the corresponding data are entered via the keyboard, and the printer automatically fills in the form.Type: GrantFiled: March 6, 1991Date of Patent: December 22, 1992Inventors: Robert S. Ledley, Thomas J. Golab
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Patent number: 4929832Abstract: A method for determining the distribution of a radioactive material in a medium is provided which comprises the steps of: (a) providing a plurality of radiation detectors at a set of predetermined locations, each of said detectors producing an electrical output indicative of the amount of radioactive material in the vicinity of the detector; (b) moving the medium containing the radioactive material and the plurality of radiation detectors relative to one another so as to position the medium relative to the detectors at each of a set of predetermined positions; and (c) recording the electrical output of each of the detectors at each of the predetermined positions. Apparatus for practicing the method is also provided.Type: GrantFiled: December 27, 1988Date of Patent: May 29, 1990Inventor: Robert S. Ledley
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Patent number: 4821728Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes parallel to the first scanning plane, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit.Type: GrantFiled: January 29, 1988Date of Patent: April 18, 1989Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 4817119Abstract: An array of radiation detectors is rotated about one or more sources of fan-shaped substantially planar radiation beams which are, in turn, rotated in the opposite direction about a three-dimensional body such that substantially parallel paths are defined between given individual detectors of the array and the radiation sources during the course of their oppositely directed movements. Radiation absorption measurements are taken along thusly defined plural intersecting sets of substantially parallel paths within a desired cross-section of the three-dimensional body to provide data for use in computing and displaying a constructed visual image of structures having different radiation absorption coefficients within the cross-section.Type: GrantFiled: August 25, 1977Date of Patent: March 28, 1989Assignee: National Biomedical Research FoundationInventors: Robert S. Ledley, James B. Wilson
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Patent number: 4798210Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit. In one embodiment, each successive scanning plane is parallel to the first scanning plane.Type: GrantFiled: September 29, 1986Date of Patent: January 17, 1989Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 4769698Abstract: A system and method for interactively displaying magnified images of an object having different respective magnifications is disclosed. The system comprises a microscope stage for holding the object, an optical arrangement for magnifying an image of the object in accordance with different respective magnifications so as to produce first and second optical outputs in corresponding first and second optical paths with different respective magnifications in each path, first and second cameras disposed in the first and second paths, and display units for displaying the first and second images of the object magnified in accordance with the different respective magnifications.Type: GrantFiled: March 16, 1987Date of Patent: September 6, 1988Assignee: National Biomedical Research FoundationInventors: Robert S. Ledley, Thomas J. Golab
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Patent number: 4747411Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes parallel to the first scanning plane, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit.Type: GrantFiled: March 28, 1984Date of Patent: May 31, 1988Assignee: National Biochemical Research FoundationInventor: Robert S. Ledley
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Patent number: 4724485Abstract: Television (TV) scanning with improved resolution is obtained by implementation into a conventional TV scanning arrangement of a vertical drive signal modifying circuit which modifies vertical drive signals prior to their being provided as an input to the conventional TV scanning arrangement. Processing of the vertical drive signals results in the generation of various time delay signals which, when logically combined in accordance with the present invention, result in the generation of modified vertical drive signals. As a result of application of the modified vertical drive signals to the conventional TV scanner arrangement, the number of fields making up the conventional interlace pattern is multiplied by an integral factor greater than one.Type: GrantFiled: September 29, 1986Date of Patent: February 9, 1988Assignee: National Biomedical Research FoundationInventors: Thomas J. Golab, Robert S. Ledley
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Patent number: 4716225Abstract: A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which entails injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into the mammalian body, and scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components.Type: GrantFiled: September 30, 1985Date of Patent: December 29, 1987Assignee: Georgetown UniversityInventors: Robert S. Ledley, Douglas M. Gersten
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Patent number: 4673973Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respective magnifications being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the path of lower magnification includes a converging lens, diverging lens, reduction lens, bending prism, TV camera and TV monitor; the path of higher magnification includes a trinocular microscope head, TV camera, and TV monitor.Type: GrantFiled: February 4, 1985Date of Patent: June 16, 1987Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 4656594Abstract: An operator-interactive automated chromosome analysis system is employed by an operator to locate and identify acceptable metaphase spreads, form a karyotype by rearranging the identified metaphase spreads in accordance with a predetermined arrangement of the twenty-three pairs of chromosomes naturally occurring in human beings, and display the karyotype on a display or a hardcopy printout, or both.Type: GrantFiled: May 6, 1985Date of Patent: April 7, 1987Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 4651200Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respectively magnified images being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the paths of lower magnification and higher magnification each include a TV camera and a TV monitor, and may include various optical elements in accordance with the four disclosed embodiments.Type: GrantFiled: October 4, 1985Date of Patent: March 17, 1987Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: 4563173Abstract: A pump-actuated sequencing valve for sequentially administering, to a patient, two fluids contained in separate respective reservoirs, wherein the fluid is pumped from a first one of the two reservoirs by means of a pump associated therewith. The valve comprises a first portion connected to the first reservoir, a second portion connected to the second reservoir, and a third portion connected between the first and second portions, on the one hand, and the patient, on the other hand. The second portion includes a ball valve which is pressure-responsive to operation of the pump for blocking flow of fluid to and from the second reservoir, thus blocking both forward flow from the second reservoir and backflow from the sequencing valve toward the second reservoir.Type: GrantFiled: April 19, 1983Date of Patent: January 7, 1986Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: RE33883Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respective magnifications being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the path of lower magnification includes a converging lens, diverging lens, reduction lens, bending prism, TV camera and TV monitor; the path of higher magnification includes a trinocular microscope head, TV camera, and TV monitor.Type: GrantFiled: June 16, 1989Date of Patent: April 14, 1992Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: RE34566Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes parallel to the first scanning plane, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit.Type: GrantFiled: November 1, 1989Date of Patent: March 22, 1994Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley
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Patent number: RE34622Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respectively magnified images being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the paths of lower magnification and higher magnification each include a TV camera and a TV monitor, and may include various optical elements in accordance with the four disclosed embodiments.Type: GrantFiled: March 16, 1989Date of Patent: May 31, 1994Assignee: National Biomedical Research FoundationInventor: Robert S. Ledley