Abstract: A method is for inserting a further data block into a first ledger, the first ledger including data blocks. In an embodiment, the method includes receiving a further medical dataset via an interface; determining the further data block via a calculation unit. The further data block includes the further medical dataset and a further link information. The further link information includes a hash of at least one of the data blocks of the first ledger. Finally, in an embodiment the method includes inserting the further data block into the first ledger via the calculation unit.

Abstract: A method and system are for providing microservice information. In an embodiment, the method includes receiving a microservice request via an interface, the microservice request being related to a first microservice; determining the microservice information by querying a microservice database based on the microservice request, via at least one processor, the microservice information being based on an instance of the first microservice and the microservice database being stored in a distributed ledger; and providing the microservice information via the interface. The inventors recognized that by using a microservice registry stored in a distributed ledger, a local copy of the microservice registry can be used for determining the microservice information based on the microservice request, leading to a low latency and a fast response time. At the same time each microservice registry can be used as a fallback for all other microservice registries.

Abstract: In some embodiments of the present disclosure, a system for providing compliance functions in a business entity is provided. The system includes a computer-implemented compliance question-answer tool configured to receive compliance related questions from a plurality of users and, in response, provide compliance related advice to the users; a computer-implemented compliance knowledge database tool including a database of compliance related data and a user interface allowing the users to search the database of compliance related data; and a computer-implemented user feedback tool including a user interface allowing the users to provide compliance related feedback to the business entity. In some embodiments, the system may also include a whistleblower tool including a user interface allowing the users to report potential compliance violations and/or a compliance activity approval tool configured to document and track activities that require an approval by a compliance entity.

Abstract: The present invention relates to a new copper-catalysed photochemnical cyclisation process for the preparation of bicylic molecules useful as intermediates in the manufacture of drugs. In a preferred aspect, the process of the invention may be used to prepare 3-hydroxy-bicyclo[3.2.0]heptane.

Abstract: This invention relates to the preparation of N,N′-carbonyldiazoles in a particularly advantageous manner by reacting corresponding azolide salts with phosgene in an aromatic compound or an ether as solvent. The azolide salts are preferably prepared by a novel process from an azole that is reacted with a compound of the formula M′R7 or MgR8Z′ in the presence of a solvent.

Abstract: This invention relates to the preparation of N,N′-carbonyldiazoles in a particularly advantageous manner by reacting corresponding azolide salts with phosgene in an aromatic compound or an ether as solvent. The azolide salts are preferably prepared by a novel process from an azole that is reacted with a compound of the formula M′R7 or MgR8Z′ in the presence of a solvent.

Abstract: Methyl carbazate which is particularly pure and has a particularly low tendency toward discoloration is obtained from hydrazine and dimethyl carbonate if the two reactants are metered simultaneously into an initially introduced first solvent at from −20 to +30° C., the solvent and low-boiling components are then distilled off under reduced pressure, and then either a second solvent is added to the crude methyl carbazate present and this solvent is distilled off under reduced pressure or an inert gas is passed through the crude methyl carbazate present.

Abstract: The invention relates to a process for the preparation of N,N′-carbonyldiazoles by reacting azoles with phosgene in a solvent, whereby the azole and the phosgene are metered into an aromatic solvent dried by incipient distillation in such a way that in the time in which 1 mol of azole is metered in, from 0.17 to 0.34 mol of phosgene is metered in simultaneously.