Abstract: A method for inhibiting biofilm formation by bacteria on a surface or disrupting existing biofilm on a surface, comprising contacting said surface or existing biofilm with at least one compound selected from the group consisting of 2-(indolin-2-yl)-1H-ind, di(1H-indol-3-yl)methane and 1,1?-biindole, is provided.

Abstract: A method for inhibiting biofilm formation by bacteria on a surface or disrupting existing biofilm on a surface, including contacting the surface or existing biofilm with 2-(indolin-2-yl)-1H-ind, di(1H-indol-3-yl)methane and 1,1?-biindole, or any combination thereof.

Abstract: This disclosure relates to a device to determine or quantify the presence of an analyte molecule, virus or cell of interest in a sample. The present disclosure also relates to a method to determine or quantify the presence of an analyte molecule, virus or cell of interest in a sample, a method of preparing the device of the disclosure, the use of the device of the disclosure for determining or quantifying the presence of an analyte molecule, virus or cell of interest in a sample and a kit of parts comprising the device of the disclosure.

Abstract: A method for inhibiting biofilm formation by bacteria on a surface or disrupting existing biofilm on a surface, including contacting the surface or existing biofilm with 2-(indolin-2-yl)-1H-ind, di(1H-indol-3-yl)methane and 1,1?-biindole, or any combination thereof.

Abstract: A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimeter. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.

Abstract: An electrochemical lateral flow biosensor (ELFB) includes an ELFB strip and electronic detector unit coupled to the strip. The strip includes a polymeric hydrophobic membrane, conjugation pad, sampling pad, screen-printed electrode (SPE), and wick pad. The membrane provides a solid support and enables capillary flow along the strip. The conjugation pad is placed on the membrane at one end of the strip and contains adsorbed dehydrated labelled conjugate particles that are coated with the biorecognition element and coated or filled with the electrochemically active component. The sampling pad is placed on the conjugation pad and provides adsorption of the liquid sample. The SPE is coated with immobilized capture antibodies. The wick pad is placed on the SPE and provides absorption of excess reagents maintaining a lateral flow along the strip. The ELFB can be used for rapid and early detection and quantity analysis of biological liquids and wastewater.

Abstract: The electrochemical lateral flow biosensor (ELFB) comprising a novel ELFB strip and electronic detector unit, to which said strip is connected using cable or wirelessly.

Abstract: A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimetre. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.

Abstract: An endotracheal intubation apparatus provides for controlled articulation of tip and central portions of a stylet having an endotracheal tube specifically configured for use therewith mounted thereon. The endotracheal intubation apparatus includes a stylet with tip and central portions that each have a curvature that is selectively and independently adjustable through one or more controls at a handle of the stylet. Through adjustment of the curvature of the tip and central portions of the stylet, a curvature of overlying portions of an endotracheal tube mounted on the stylet can be selectively and independently adjusted. Advantageously, such selectively and independently adjustment of the curvature of the tip and central portions of the stylet allows a contour of the endotracheal tube to be selectively adjusted for accommodating a particular airway anatomy of a patient without requiring removal of the endotracheal intubation apparatus.

Abstract: The present invention provides novel mucoadhesive compounds useful in the prevention of diseases and disorders of or which are associated with the mucosal membrane.

Abstract: The present invention provides novel mucoadhesive compounds useful in the prevention of diseases and disorders of or which are associated with the mucosal membrane.

Abstract: The invention relates biosensor comprising a conductive or semi-conductive support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator. The invention also relates to a method for the detection of a DNA sequence with the biosensor, comprising the steps of: hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor.

Abstract: The invention relates biosensor comprising a conductive or semi-conductive support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator. The invention also relates to a method for the detection of a DNA sequence with the biosensor, comprising the steps of: hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor.

Abstract: A method of assessing the in vivo state of phagocytes in a patient, possibly indicating diagnostically important states such as inflammation or infection, which method utilizes chemiluminescent (CL) light emitted during the reaction in vitro between a CL substrate and the reactive oxygen species (ROS) formed in a fluid sample obtained from the patient. The measurement is performed in two or more portions of the sample, with stimulated phagocytes affected by one or more priming agents which shift the functional state of the phagocytes, providing a plurality of measurements, which are analyzed so as to distinguish intracellular and extracellular contributions to the CL kinetics. The results are compared with a range of control measurements performed with patients suffering from various diagnostic conditions.

Abstract: The present invention provides novel mucoadhesive compounds useful in the prevention of diseases and disorders of or which arc associated with the mucosal membrane.