Patents by Inventor Robert S. Mittler

Robert S. Mittler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding humanized antibodies against human 4-1BB
    Patent number: 7214493
    Abstract: A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: May 8, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maria Jure Kunkel, Subinay Ganguly, Ralph Abraham, Diane L. Hollenbaugh, Jill Rillema, Barbara Thorne, Walter W. Shuford, Robert S. Mittler
  • Humanized antibodies against human 4-1BB
    Patent number: 6887673
    Abstract: A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: May 3, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maria Jure Kunkel, Subinay Ganguly, Ralph Abraham, Diane L. Hollenbaugh, Jill Rillema, Barbara Thorne, Walter W. Shuford, Robert S. Mittler
  • Humanized antibodies against human 4-1BB
    Publication number: 20040105855
    Abstract: A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
    Type: Application
    Filed: July 30, 2003
    Publication date: June 3, 2004
    Inventors: Maria Jure Kunkel, Subinay Ganguly, Ralph Abraham, Diane L. Hollenbaugh, Jill Rillema, Barbara Thorne, Walter W. Shuford, Robert S. Mittler
  • Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40
    Publication number: 20030118588
    Abstract: Disclosed is a method and composition for treating tumors or infectious diseases, wherein the composition comprises an agonist anti-CD40 antibody or a fragment thereof. The anti-CD40 antibody molecules include fragments like Fab, (Fab′)2 and Fv. The composition can also include an agonistic anti-4-1BB antibody or fragment thereof.
    Type: Application
    Filed: April 4, 2002
    Publication date: June 26, 2003
    Inventors: Linda Diehl, Geertje van Mierlo, Robert S. Mittler, Cornelis J.M. Melief, Rene Toes, Rienk Offringa
  • Methods and compositions for immunomodulation
    Patent number: 6210669
    Abstract: The instant invention discloses the unexpected result that two anti-4-1BB monoclonal antibodies can inhibit both primary and secondary humoral responses to at least T-cell dependent antigens in vivo. Such antibodies provide a novel approach to immunosuppression and cancer therapy in vivo.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: April 3, 2001
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Alejandro A. Aruffo, N. Jan Chalupny, Lieping Chen, Robert S. Mittler, Walter W. Shuford, Anthony W. Siadak