Abstract: Mass defect labeled peptides and methods of identifying peptides are provided. In particular, embodiments of the present disclosure include mass defect labels for polypeptides that include at least one cysteine and/or at least one tryptophan and methods of using the mass defect labels to identify polypeptides. One embodiment, among others, includes a mass defect labeled peptide including at least one cysteine residue labeled with 2,4-dibromo-acetanilide. Another embodiment, among others, includes a mass defect labeled peptide including at least one tryptophan residue labeled with 4,6-dibromo-2-trifluoromethylphenylsulfenyl chloride.

Abstract: Briefly described, embodiments of this disclosure include mass defect labeled peptides, methods of identifying peptides, and the like.

Abstract: In a network of computer nodes, a directory service provides both the physical location of directory information around the network and the directory information itself in a single data structure. This single data structure is distributed throughout the network, and continuously redistributed, so as to create a directory service that is both more flexible, and more robust, than prior art directory services.

Abstract: A multi-user file storage service and system enable each user of a pre-subscribed user group to communicate with a remote file server node via a wide area network and to access the files of the file group via the respective client node. More than one user of the pre-subscribed user group is permitted to access the file group at the remote file server node simultaneously. Integrity of the files at the remote file server node are maintained by controlling each access to each file at the remote file server node so that each access to files at the remote file server is performed, if at all, on a respective portion of each file as most recently updated at the remote file server node. Additionally, an encrypted key is transferred from the file server node to a particular client node via a secure channel. The encrypted key uses an encryption function and a decryption function not known locally at the remote file server.

Abstract: A multi-user file storage service and system enables each user of a user group to operate an arbitrary client node at an arbitrary geographic location to communicate with a remote file server node via a wide area network. More than one user of the user group is permitted to access the file group at the remote file server node simultaneously, but the integrity of the files is maintained by controlling access so that each access to one of the files at the remote file server is performed, if at all, on a respective portion of that file as most recently updated at the remote file server node.

Abstract: In a network of computer nodes, a directory service provides both the physical location of directory information around the network and the directory information itself in a single data structure.

Abstract: In a network of computer nodes, a directory service provides both the physical location of directory information around the network and the directory information itself in a single data structure. This single data structure is distributed throughout the network, and continuously redistributed, so as to create a directory service that is both more flexible, and more robust, than prior art directory services.

Abstract: Distributed shared memory systems and processes that can connect into each node of a computer network to encapsulate the memory management operations of the connected nodes and to provide thereby an abstraction of a shared virtual memory that can span across each node of the network and that optionally spans across each memory device connected to the computer network. Accordingly, each node on the network having the distributed shared memory system of the invention can access the shared memory.

Abstract: A network of computer node interface to globally addressable memory system that provides persistent storage of data exchange periodic connectivity information. The exchanged connectivity information provides information regarding node failure to other nodes in the system, and the surviving nodes use the information to determine which node, if any, has ceased functioning. Various processes are used to recover the portion of the global address space for which the failed node was responsible, including RAM directory, disk directory, or file system information. Additionally, nodes may be subdivided into groups and connectivity information is exchanged between nodes belonging to a group. Each group then exchanges group-wise connectivity information and failures may be recovered.

Abstract: A pump assembly (20) includes a rotor (40) and a stator (38) which are disposed within a housing (24) and partially define pumping chambers (56). Fluid is conducted through an inlet passage (104) to an inlet cavity (58) which is connected with the pumping chambers (56). Fluid is conducted from the pumping chambers (56) to an outlet (62) from the pump assembly (20). A tubular passage liner (112) is disposed in the inlet passage (104) and has a straight passage (138) through which fluid flow is conducted to the inlet cavity (58). The tubular passage liner (112) prevents erosion of the housing (24) during conduction through the inlet passage (104) of inlet fluid and fluid bypassed from the outlet (62) of the pump assembly (20). Projections (204 and 206) at one end of the tubular passage liner (112) are engageable with the stator (38) to limit movement of the tubular passage liner relative to the stator.

Abstract: A pump assembly (20) includes a rotor (40) and a stator (38) which are disposed within a housing (24) and partially define pumping chambers (56). Fluid is conducted through an inlet passage (104) to an inlet cavity (58) which is connected with the pumping chambers (56). Fluid is conducted from the pumping chambers (56) to an outlet (62) from the pump assembly (20). A tubular passage liner (112) is disposed in the inlet passage (104) and has a straight passage (138) through which fluid flow is conducted to the inlet cavity (58). The tubular passage liner (112) prevents erosion of the housing (24) during conduction through the inlet passage (104) of inlet fluid and fluid bypassed from the outlet (62) of the pump assembly (20). Projections (204 and 206) at one end of the tubular passage liner (112) are engageable with the stator (38) to limit movement of the tubular passage liner relative to the stator.

Abstract: The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CHOH, S, SO.sub.2, SO, SONH, PO.sub.2 H or PONH.sub.2, R.sub.A and R.sub.B, independently of one another, are H, a halogen, CF.sub.3 or a small alkyl group having one to three carbon atoms; A is a H or an acetyl group; R.sub.1 is H, NH.sub.2, NR.sub.6 R.sub.7, NO.sub.2, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms, wherein: R.sub.6 and R.sub.7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R.sub.6 or R.sub.7 can be a formyl group; R.sub.2 is OH, H, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms; and R.sub.3, R.sub.4 and R.sub.5, independently of one another, are H, halogen, CF.sub.3, NO.sub.2, NH.sub.2, or small alkyl group having from one to three carbon atoms. In particular, compounds of this formula in which X is CHOH, S or SO.sub.

Abstract: An improved rotary device (20), such as a fluid pump or motor, includes a housing (24) which encloses a working unit (22). The working unit (22) includes a cam ring (38) which cooperates with a rotor (40) and a plurality of vanes (42) to form a plurality of variable volume working chambers. The housing (24) includes a main section (26) and a cover section (28). The main section (26) of the housing (24) has three separate risers (122, 124 and 126). Any one of the three risers (122, 124 or 126) may be connected with a fluid conduit (116). The main and cover sections (26 and 28) of the housing (24) are movable relative to each other to enable the rotary device (20) to be mounted in a selected one of a plurality of orientations on a support structure.

Abstract: The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CO or CHOH; R.sub.A and R.sub.B, independently of one another, are H, a halogen, a halovinyl group, or a small alkyl or haloalkyl group having one to three carbon atoms; A is a H or an acetyl group; R.sub.1 is H, NH.sub.2, NR.sub.6 R.sub.7, NO.sub.2, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms, wherein: R.sub.6 and R.sub.7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R.sub.6 or R.sub.7 can be a formyl group; R.sub.2 is OH, H, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms; and R.sub.3, R.sub.4 and R.sub.5, independently of one another, are H, halogen, CF.sub.3, NO.sub.2, NH.sub.2, or small alkyl group having from one to three carbon atoms, and with the proviso that when X=CO, neither R.sub.A nor R.sub.B can be CF.sub.3.

Abstract: The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CHOH, S, SO.sub.2, SO, SONH.sub.2, PO.sub.2 H or PONH.sub.2, R.sub.a and R.sub.b, independently of one another are H, a halogen, CF.sub.3 or a small alkyl group having one to three carbon atoms; R.sub.1 is H, NH.sub.2, NR.sub.6 RT, NO.sub.2, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms, wherein: R.sub.6 and R.sub.7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R.sub.6 or R.sub.7 can be a formyl group; R.sub.2 is OH, H, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms; and R.sub.3, R.sub.4 and R.sub.5, independently of one another, are H, halogen, CF.sub.3, NO.sub.2, NH.sub.2, or small alkyl group having from one to three carbon atoms. In particular, compounds of this formula in which X is CHOH, S or SO.sub.2 are provided.

Abstract: An improved cartridge assembly (10) is used in a pump to bypass excess fluid flow and vent excess fluid pressure. The cartridge assembly includes a housing (24) which is located in and fixedly secured to a pump body (14). An orifice (62) is disposed within the housing (24) to establish a pressure differential in a flow of fluid from an inlet (34) to the housing to an outlet (42) from the housing. A fluid bypass port (38) is formed in the housing (24). A flow control valve (66) is disposed within the housing (24) and is movable relative to the housing to control the flow of fluid through the bypass port (38). A pressure relief valve assembly (104) is disposed in the housing (24) and is operable to an open condition to vent excess fluid pressure to the bypass port (38) through passages (106 and 107) formed in the flow control valve (66). The pressure relief valve assembly (104) is connected with the flow control valve (66) and moves with the flow control valve relative to the housing (24).

Abstract: The present invention provides inhibitors of kynureninase having the formula ##STR1## where R.sub.a and R.sub.b, independently of one another are H, a halogen, CF.sub.3 or a small alkyl group having one to three carbon atoms; R.sub.1 is NH.sub.2, NR.sub.6 R.sub.7, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms, wherein R.sub.6 and R.sub.7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R.sub.6 or R.sub.7 can be a formyl group; R.sub.2 is OH, H, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms; and R.sub.3, R.sub.4 and R.sub.5, independently of one another, are H, halogen, CF.sub.3 or small alkyl group having from one to three carbon atoms. In particular, compounds of formula I having the (.alpha.S,.gamma.S) configuration or (.alpha.R,.gamma.R) configuration when R.sub.A or R.sub.B is a halogen are more potent inhibitors of kynureninase.

Abstract: Hypertension in mammals can be treated by administering an effective amount of an aminoalkyl phenyl sulfide having the formula ##STR1## wherein (C.sub.n H.sub.2n)=a linear or branched alkyl chain of 10 carbons or less (n=1-10);R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,=H, OH, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, F, Cl, Br, or I;R.sub.6 R.sub.7 =H, C.sub.1 -C.sub.4 -alkyl;and the pharmaceutically acceptable salts thereof. The hypotensive potential of the compounds may be evaluated by oxygenation with dopamine-beta-hydroxylase.