Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3? OH kinase family (hereinafter PI3 kinases), suitably, PI3K?, PI3K?, PI3K?, and/or PI3K?. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3K? selective benzimidazoles compounds for treating cancer.

Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3? OH kinase family (hereinafter PI3 kinases), suitably, PI3K?, PI3K?, PI3K?, and/or PI3K?. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3K? selective benzimidazoles compounds for treating cancer.

Abstract: Systems and methods are provided for a two-way chat. In one aspect there is provided a system including a processor, which further includes a memory. The processor and memory provide a web client application. The system further includes a mobile wireless device and a centralized server. The centralized server provides a two-way chat between the web client application and the mobile wireless device.

Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3? OH kinase family (hereinafter PI3 kinases), suitably, PI3K?, PI3K?, PI3K?, and/or PI3K?. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3K? selective benzimidazoles compounds for treating cancer.

Abstract: An intraocular pressure sensor system has a first pressure sensor located in an anterior chamber of an eye and a remote pressure sensor located remotely from the first pressure sensor. The remote pressure sensor measures or approximates atmospheric pressure. A difference between readings from the first pressure sensor and the remote pressure sensor approximates intraocular pressure.

Abstract: Systems and methods are provided for a two-way chat. In one aspect there is provided a system including a processor, which further includes a memory. The processor and memory provide a web client application. The system further includes a mobile wireless device and a centralized server. The centralized server provides a two-way chat between the web client application and the mobile wireless device.

Abstract: A urine collection device and a moisture-wicking article for use in a system for transporting urine voided from a person or an animal by collecting the urine in a moisture-wicking article that is disposed in contact with a region surrounding an urethral, opening, and drawing the urine into the collection device from the moisture-wicking article. The urine collection device includes a container defining an empty chamber for collecting urine. An elongated exterior of the container is configured and dimensioned for enabling a moisture-wicking article to be secured over the array of openings of the container by wrapping the article over the array and securing the wrapped article, and for enabling a said secured moisture-wicking article to be disposed in contact with the region of a female body surrounding the urethral opening.

Abstract: An intraocular pressure sensor system has a first pressure sensor located in an anterior chamber of an eye and a remote pressure sensor located remotely from the first pressure sensor. The remote pressure sensor measures or approximates atmospheric pressure. A difference between readings from the first pressure sensor and the remote pressure sensor approximates intraocular pressure.

Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3? OH kinase family (hereinafter PI3 kinases), suitably, PI3K?, PI3K?, PI3K?, and/or PI3K?. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3K? selective benzimidazoles compounds for treating cancer.

Abstract: Systems and methods are provided for a two-way chat. In one aspect there is provided a system including a processor, which further includes a memory. The processor and memory provide a web client application. The system further includes a mobile wireless device, and a centralized server. The centralized server provides a two-way chat between the web client application and the mobile wireless device.

Abstract: Systems and methods are provided for a two-way chat. In one aspect there is provided a system including a processor, which further includes a memory. The processor and memory provide a web client application. The system further includes a mobile wireless device and a centralized server. The centralized server provides a two-way chat between the web client application and the mobile wireless device.

Abstract: An intraocular pressure sensor system has a first pressure sensor located in an anterior chamber of an eye and a remote pressure sensor located remotely from the first pressure sensor. The remote pressure sensor measures or approximates atmospheric pressure. A difference between readings from the first pressure sensor and the remote pressure sensor approximates intraocular pressure.

Abstract: An injection device assembly includes a dispensing chamber housing and a plunger. The dispensing chamber housing is coupled to a needle. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. A dosage of a substance is cast into the dispensing chamber housing or cast onto a plunger that is inserted into the dispensing chamber housing.

Abstract: An ophthalmic injection system has a tip segment attachable to and removable from a limited reuse assembly. The tip segment has a dispensing chamber housing, a plunger, a needle, a temperature control device, a thermal sensor, and a first housing at least partially enclosing the dispensing chamber housing, the temperature control device and the plunger. The limited reuse assembly has an actuator with a shaft, a power source for providing power to the actuator, a controller for controlling the actuator, a mechanical linkage interface, and a second housing at least partially enclosing the power source, the controller, and the actuator. The mechanical linkage interface is coupled to the actuator shaft and has a mating surface on one end. The substance is injected after the temperature of the substance is altered.

Abstract: A disposable injection device has a dispensing chamber housing, a plunger, a needle, and a temperature control device. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The plunger has a plunger interface. The needle is fluidly coupled to the dispensing chamber. The temperature control device at least partially surrounds the dispensing chamber housing and alters a temperature of the substance in the dispensing chamber. The substance is injected after the temperature of the substance is altered.

Abstract: A method of delivering a substance into an eye includes recognizing a connection between a tip segment and a limited reuse assembly; receiving dosage information from the tip segment; activating a temperature control device to alter a temperature of a substance to be delivered into an eye; receiving temperature information from a thermal sensor; using the temperature information to control the temperature control device; receiving an input indicating that the substance is to be delivered; and based on the dosage information, controlling an actuator to move a plunger to deliver the substance.

Abstract: An ophthalmic injection system has a tip segment attachable to and removable from a limited reuse assembly. The tip segment has a dispensing chamber housing, a plunger, a needle, a temperature control device, a thermal sensor, and a first housing at least partially enclosing the dispensing chamber housing, the temperature control device and the plunger. The limited reuse assembly has an actuator with a shaft, a power source for providing power to the actuator, a controller for controlling the actuator, a mechanical linkage interface, and a second housing at least partially enclosing the power source, the controller, and the actuator. The mechanical linkage interface is coupled to the actuator shaft and has a mating surface on one end. The substance is injected after the temperature of the substance is altered.

Abstract: A method of injecting a substance into an eye is disclosed. A connection between a disposable tip segment and a limited reuse assembly is recognized. A temperature control device is activated to alter the temperature of a substance contained in a dispensing chamber. Dosage information is read. In response to the dosage information, a mechanical linkage interface is advanced to advance a plunger to expel the substance from the dispensing chamber. The mechanical linkage interface is retracted without substantially retracting the plunger to prevent reflux of the substance. Reuse of the disposable tip segment is prevented. The removal of the disposable tip segment from the limited reuse assembly is recognized.

Abstract: An injection device assembly includes a dispensing chamber housing and a plunger. The dispensing chamber housing is coupled to a needle. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. A dosage of a substance is cast into the dispensing chamber housing or cast onto a plunger that is inserted into the dispensing chamber housing.

Abstract: A disposable injection device has a dispensing chamber housing and a plunger. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The plunger has a plunger interface. The plunger interface mates with a mating surface on a mechanical linkage interface such that force is transferred from the mechanical linkage interface to the plunger along a first direction towards the plunger when the plunger interface is in contact with the mating surface of the mechanical linkage interface, and force is not substantially transferred from the mechanical linkage interface to the plunger along a second direction away from the plunger.