Abstract: Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.

Abstract: Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.

Abstract: The present disclosure relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment of neurological diseases having the Formula I: where R1, R2, L1, L2, X, Y, and Y? are described therein.

Abstract: A child restraint base adapted to a child restraint carrier is disclosed herein. The child restraint base includes a base body including a first pocket and a second pocket. The first pocket and the second pocket are disposed on front lateral sides of the base body. An anchor belt is included that comprises a first anchor attached to a first end of the anchor belt, and a second anchor attached to a second end of the anchor belt. The first pocket is configured to receive at least a portion of the first anchor, and the second pocket is configured to receive at least a portion of the second anchor. A panel is pivotable between an opened position and a closed position, and the panel pivots to the closed position to tension the anchor belt to remove slack from the anchor belt.

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

Abstract: Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated to modulate the NMDA receptor.

Abstract: Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) an adjacent exon sequence of a 3? Group I self-splicing intron-exon, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) an adjacent exon sequence of a 5? Group I self-splicing intron-exon.

Abstract: A support base for a child safety seat includes a pivotable support leg that is operable to retract and expand from the support base, the support leg including multiple segments connected with one another via a plurality of sliding connections, the sliding connections including a first and a second sliding connection. Moreover, the support base includes an actuating button operably coupled to a first and a second latch. The first latch is operable to lock and unlock the first sliding connection for preventing or allowing relative sliding between segments of the first sliding connection. The second latch is operable to lock and unlock the second sliding connection for preventing or allowing relative sliding between segments of the second sliding connection. When the actuating button is actuated, the first latch is urged to unlock the first sliding connection and the second latch is urged to unlock the second sliding connection.

Abstract: A support base for a child safety seat includes a support leg operable to retract and expand at a bottom of the support base, an actuating part operably coupled to a first and a second latch, and an actuating button. The support leg includes multiple segments, and a first and a second sliding connection each of which respectively coupling two adjacent ones of the segments. The first latch is operable to lock and unlock the first sliding connection. The second latch is operable to lock and unlock the second sliding connection. The actuating part is operable to urge the first latch to move for unlocking the first sliding connection and to urge the second latch to move for unlocking the second sliding connection. The actuating button is assembled with the first segment adjacent to a distal end of thereof, and is operable to actuate the actuating part.

Abstract: A child restraint base adapted to a child restraint carrier is disclosed herein. The child restraint base includes a base body including a first pocket and a second pocket. The first pocket and the second pocket are disposed on front lateral sides of the base body. An anchor belt is included that comprises a first anchor attached to a first end of the anchor belt, and a second anchor attached to a second end of the anchor belt. The first pocket is configured to receive at least a portion of the first anchor, and the second pocket is configured to receive at least a portion of the second anchor. A panel is pivotable between an opened position and a closed position, and the panel pivots to the closed position to tension the anchor belt to remove slack from the anchor belt.

Abstract: A child restraint base adapted to a child restraint carrier is disclosed herein. The child restraint base includes a base body including a first pocket and a second pocket. The first pocket and the second pocket are disposed on front lateral sides of the base body. An anchor belt is included that comprises a first anchor attached to a first end of the anchor belt, and a second anchor attached to a second end of the anchor belt. The first pocket is configured to receive at least a portion of the first anchor, and the second pocket is configured to receive at least a portion of the second anchor. A panel is pivotable between an opened position and a closed position, and the panel pivots to the closed position to tension the anchor belt to remove slack from the anchor belt.

Abstract: A support base for a child safety seat includes a support leg operable to retract and expand at a bottom of the support base, an actuating part operably coupled to a first and a second latch, and an actuating button. The support leg includes multiple segments, and a first and a second sliding connection each of which respectively coupling two adjacent ones of the segments. The first latch is operable to lock and unlock the first sliding connection. The second latch is operable to lock and unlock the second sliding connection. The actuating part is operable to urge the first latch to move for unlocking the first sliding connection and to urge the second latch to move for unlocking the second sliding connection. The actuating button is assembled with the first segment adjacent to a distal end of thereof, and is operable to actuate the actuating part.

Abstract: A child restraint base adapted for a child restraint carrier includes a base body for mounting the child restraint carrier, a first panel component, a second panel component, an anchor belt and a third panel component. The first panel component and the second panel component are disposed on the base body and spaced from each other. A first through slot is formed between the first panel component and the base body. A second through slot is formed between the second panel component and the base body. The anchor belt passes through the first through slot and the second through slot and is slidable between an in-use position and a stored position. The third panel component is disposed between the first panel component and the second panel component and pivotable between an opened position and a closed position for tensioning the anchor belt to remove slack from the anchor belt.

Abstract: A support base for a child safety seat includes a support leg operable to retract and expand at a bottom of the support base, a first and a second locking mechanism, and a linking assembly. The support leg includes multiple segments, and a first and a second sliding connection each of which respectively coupling two adjacent ones of the segments. The first locking mechanism includes a first latch operable to lock the first sliding connection, and a first actuating part operable to urge the first latch to move for unlocking the first sliding connection. The second locking mechanism includes a second latch operable to lock the second sliding connection, and a second actuating part operable to urge the second latch to move for unlocking the second sliding connection. The linking assembly couples the two locking mechanisms so that the first and second sliding connections can be concurrently unlocked.

Abstract: A convertible child restraint includes a lower base to contact a vehicle seat, a seat shell to support a child, and a mid base between the lower base and the seat shell to facilitate recline and rotational adjustment of the seat shell relative to the lower base. The child restraint may be used as a rear-facing car seat, a forward-facing car seat, and a belt positioning booster seat. For the rear-facing car seat configuration, a belt is installed along a rear-facing belt path that passes through the child restraint. The portion of the belt in the child restraint is accessed via a belt access panel when the seat shell is at a rear-facing position. Additionally, the child restraint includes a rotation lockout that allows the seat shell to be rotated from a rear-facing position to a side-facing position, but not a forward-facing position when using the rear-facing configuration.

Abstract: A child restraint base adapted to a child restraint carrier is disclosed herein. The child restraint base includes a base body including a first pocket and a second pocket. The first pocket and the second pocket are disposed on front lateral sides of the base body. An anchor belt is included that comprises a first anchor attached to a first end of the anchor belt, and a second anchor attached to a second end of the anchor belt. The first pocket is configured to receive at least a portion of the first anchor, and the second pocket is configured to receive at least a portion of the second anchor. A panel is pivotable between an opened position and a closed position, and the panel pivots to the closed position to tension the anchor belt to remove slack from the anchor belt.