Abstract: Tissue explants of the gastrointestinal tract are provided. Methods of making and using the tissue explants are also provided, along with substrates designed for the tissue explants described.

Abstract: A video packaging and origination service can include one or more encoder components that receive content for encoding and transmitting to requesting entities. During the operation of the encoder components, individual encoders receive input signals for encoding and determine quality metric information related to the generation of an encoded segment. The encoder components exchange quality metric information and an encoder component is selected to transmit an encoded segment. The selection of an individual encoder component per segment can continue throughout the streaming process.

Abstract: The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of CASTOR1, as well as to the use of such identified compounds in the modulation of mTORC1 and the treatment of diseases and conditions characterized by aberrant mTORC1 activity.

Abstract: A content stream matching and processing process is provided. A computing device receives a plurality of content streams. The computing device processes the content streams to generate picture data information. The picture data information can be utilized to determine whether the content streams can be aligned. Based on the alignment, the computing device can characterize the similarity of the content streams.

Abstract: Systems and methods are described to enable synchronized encoding of streaming audio or video content between multiple encoders, in a manner that provides for seamlessly interchangeable encodings. Within a pool of encoders, each encoder can generate state information regarding its state of encoding, and share that state information with a controller. The control can compare the state information of the various encoders to determine whether a desynchronization has occurred. When a desynchronization does occur, such as due to intermittent network packet loss, the controller can determine an authoritative state for the pool, and instruct desynchronized encoders to resynchronize to the authoritative state, resulting in identical or interchangeable encoded content being output from each encoder of the pool.

Abstract: A video packaging and origination service can include one or more encoder components that receive content for encoding and transmitting to requesting entities. During the operation of the encoder components, individual encoders receive input signals for encoding and determine quality metric information related to the generation of an encoded segment. The encoder components exchange quality metric information and an encoder component is selected to transmit an encoded segment. The selection of an individual encoder component per segment can continue throughout the streaming process.

Abstract: Systems and methods are described to enable replacement, in a packaged content stream, of a first encoded content stream with a second encoded content stream, without requiring decoding of the encoded content streams. A controller can receive a request to replace the first encoded content stream with the second encoded content stream at a specified location (e.g., a particular time). The controller can then instruct encoders associated with the respective content streams to insert a splice point frame into the respective content streams at the specified location, which splice point frame breaks inter frame dependency before and after the splice point frame. A packager can then replace the first encoded content stream with the second encoded content stream at the location of the splice point frame in the packaged content stream, without introducing errors into the packaged content stream as a result of broken inter frame dependency.

Abstract: Media inputs, such as serial digital interface (SDI) inputs, can be concurrently monitored and ingested. An ingest process can be configured to concurrently monitor each of a set of SDI inputs. A transcoding job requiring content from one of the inputs can send a request over shared memory to the ingest process, which can copy the data to the media transcoding pipeline over shared memory while concurrently monitoring the SDI inputs. In at least some embodiments, multiple processes can concurrently ingest from a single SDI input.

Abstract: Systems and methods are described to enable synchronized encoding of streaming audio or video content between multiple encoders, in a manner that provides for seamlessly interchangeable encodings. A first encoding begins encoding streaming content at a first point in time, and at a later point in time, a second encoder is configured to begin encoding the streaming content in a manner synchronized with the first encoder. The second encoder communicates via a synchronization protocol with the first encoder, and receives state information of the first encoder, such as a timecode of the streaming content at which the first encoder began encoding. The second encoder uses the received state information to determine a difference in encoding start times between the first and second encoder, and to adjust its timestamp values to match those of the first encoder. Thereafter, the first and second encoders can encode content in a synchronized manner.

Abstract: Systems and methods are described to enable synchronized encoding of streaming audio or video content between multiple encoders, in a manner that provides for seamlessly interchangeable encodings. Within a pool of encoders, each encoder can periodically generate state information regarding its state of encoding, and share that state information with other encoders. The other encoders can compare the state information to their current state, to determine whether a desynchronization has occurred. When a desynchronization does occur, such as due to intermittent network packet loss, the encoders within the pool can evaluate the shared state information to determine an authoritative state, and then resynchronize to the authoritative state, resulting in identical or interchangeable encoded content being output from each encoder of the pool.

Abstract: A video packaging and origination service can include one or more encoder components that receive content for encoding and transmitting to requesting entities. During the operation of the encoder components, individual encoders receive input signals for encoding and determine quality metric information related to the generation of an encoded segment. The encoder components exchange quality metric information and an encoder component is selected to transmit an encoded segment. The selection of an individual encoder component per segment can continue throughout the streaming process.

Abstract: A video packaging and origination service can include one or more encoder components that receive content for encoding and transmitting to requesting entities. During the operation of the encoder components, individual encoders receive input signals for encoding and determine picture data related to the generation of an encoded segment. The encoder components exchange picture data information and individual encoder components select synchronization information based processing the exchanged picture data information. The exchange of picture data and synchronization can continue throughout the streaming process.

Abstract: The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of CASTOR1, as well as to the use of such identified compounds in the modulation of mTORC1 and the treatment of diseases and conditions characterized by aberrant mTORC1 activity.

Abstract: The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.

Abstract: The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.

Abstract: An oligomerization process in which hydrocarbon feedstocks are contacted with a hydrotreating catalyst in the absence of hydrogen and in the liquid phase. The catalyst is a heterogeneous catalyst selected from supported reduced metals, metals oxides, metal sulfides and combinations thereof. Preferred catalysts include mixed nickel and molybdenum oxides or mixed cobalt and molybdenum oxides. The process also oligomerizes sulfur compounds so that sulfur containing feedstocks can be treated without deactivating the catalysts.

Abstract: The synthesis of a crystalline material, in particular, a high silica zeolite, comprising a chabazite-type framework molecular sieve is conducted in the presence of an organic directing agent having the formula: [R1R2R3N—R4]+Q? wherein R1 and R2 are independently selected from hydrocarbyl groups and hydroxy-substituted hydrocarbyl groups having from 1 to 3 carbon atoms, provided that R1 and R2 may be joined to form a nitrogen-containing heterocyclic structure, R3 is an alkyl group having 2 to 4 carbon atoms and R4 is selected from a 4- to 8-membered cycloalkyl group, optionally, substituted by 1 to 3 alkyl groups each having from 1 to 3 carbon atoms; and a 4- to 8-membered heterocyclic group having from 1 to 3 heteroatoms, said heterocyclic group being, optionally, substituted by 1 to 3 alkyl groups each having from 1 to 3 carbon atoms and the or each heteroatom in said heterocyclic group being selected from the group consisting of O, N, and S, or R3 and R4 are hydrocarbyl groups having from 1 to 3 carbon a

Abstract: An apparatus for parallel processing of reaction mixtures comprises a plurality of vessels for holding a plurality of reaction mixtures for processing. A plurality of vessel supports are adapted for supporting the plurality of vessels. Caps sealingly engage the vessel supports for sealing the vessels within the vessel supports. The vessels, vessel supports, and caps define reaction chambers having bearings and stirrers rotatable therein. The stirrers each comprise a spindle rotatable in a respective bearing and at least one stirring implement extending from the spindle for contacting a respective reaction mixture. The stirrers further comprise at least one magnet adapted to be subjected to a rotating magnetic field in the vessel for causing the stirrer to rotate thereby to mix the respective reaction mixture.

Abstract: A crystalline material is described that has an AEI framework type, wherein the material, in its calcined, anhydrous form, has a composition involving the molar relationship: (n)X2O3:YO2, wherein X is a trivalent element, Y is a tetravalent element n is from 0 to less than 0.01. The material is normally synthesized in a halide, typically a fluoride, medium and exhibits activity and selectivity in the conversion of methanol to lower olefins, especially ethylene and propylene.

Abstract: The synthesis of a crystalline material, in particular a high silica zeolite, having a chabazite-type framework is aided by the addition to the synthesis mixture of seeds of an AEI framework-type material. The chabazite-type product has a relatively small crystal size and exhibits activity and selectivity in the conversion of methanol to lower olefins, especially ethylene and propylene.