Patents by Inventor Robert Schiffers

Robert Schiffers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of an indolinone derivative
    Patent number: 8304541
    Abstract: The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: November 6, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Joern Merten, Guenter Linz, Juergen Schnaubelt, Rolf Schmid, Werner Rall, Svenja Renner, Carsten Reichel, Robert Schiffers
  • PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE
    Publication number: 20110201812
    Abstract: The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.
    Type: Application
    Filed: December 2, 2008
    Publication date: August 18, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Joern Merten, Guenter Linz, Juegen Schnaubelt, Rolf Schmid, Werner Rall, Svenja Renner, Carsten Reichel, Robert Schiffers
  • Process for manufacturing of enantiomerically pure 3-hydroxy-3-phenyl-propylamin
    Patent number: 7294744
    Abstract: The present invention relates to an improved process for preparing enantiomerically pure 3-hydroxy-3-phenyl-propylamines on an industrial scale using asymmetrical hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and chiral 4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: November 13, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Wolfgang Baumgarten, Robert Schiffers
  • Process for manufacturing of enantiomerically pure 3-hydroxy-3-phenyl-propylamin
    Publication number: 20060009533
    Abstract: The present invention relates to an improved process for preparing enantiomerically pure 3-hydroxy-3-phenyl-propylamines on an industrial scale using asymmetrical hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and chiral 4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 12, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Wolfgang Baumgarten, Robert Schiffers
  • Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
    Publication number: 20050197503
    Abstract: The present invention relates to an improved process for preparing chiral N-substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine on an industrial scale using an asymmetric hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.
    Type: Application
    Filed: February 16, 2005
    Publication date: September 8, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Robert Schiffers, Paul Kreye, Wolfgang Baumgarten, Rosemarie Collet