Patents by Inventor Robert Schnepf

Robert Schnepf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric Prodrugs with a Self-Immolative Linker
    Publication number: 20210283264
    Abstract: A cascade carrier linked prodrug is described comprising a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
    Type: Application
    Filed: January 6, 2021
    Publication date: September 16, 2021
    Applicant: Ascendis Pharma GmbH
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Hydrogel formulations
    Patent number: 10029015
    Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: July 24, 2018
    Assignee: ASCENDIS PHARMA A/S
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • POLYMERIC PRODRUG WITH A SELF-IMMOLATIVE LINKER
    Publication number: 20160089448
    Abstract: A cascade carrier linked prodrug is described comprising a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 31, 2016
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Polymeric prodrug with self-immolative linker
    Patent number: 9238686
    Abstract: A cascade carrier linked prodrug is described comprising a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: January 19, 2016
    Assignee: Ascendis Pharma GmbH
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • HYDROGEL FORMULATIONS
    Publication number: 20150238625
    Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 27, 2015
    Applicant: ASCENDIS PHARMA A/S
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Hydrogel formulations
    Patent number: 9056126
    Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: June 16, 2015
    Assignee: ASCENDIS PHARMA A/S
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Protein-proteophore complexes
    Patent number: 8450097
    Abstract: The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: May 28, 2013
    Assignee: Ascendis Pharma GmbH
    Inventors: Dirk Vetter, Ulrich Hersel, Harald Rau, Robert Schnepf, Thomas Wegge
  • Polymeric prodrug with a self-immolative linker
    Patent number: 8377917
    Abstract: A cascade carrier linked prodrug is described which comprises a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: February 19, 2013
    Assignee: Complex BioSystems GmbH
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • HYDROGEL FORMULATIONS
    Publication number: 20110223230
    Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
    Type: Application
    Filed: May 19, 2011
    Publication date: September 15, 2011
    Applicant: ASCENDIS PHARMA A/S
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Protein-Proteophore Complexes
    Publication number: 20110172390
    Abstract: The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
    Type: Application
    Filed: December 14, 2010
    Publication date: July 14, 2011
    Applicant: Ascendis Pharma A/S
    Inventors: Dirk Vetter, Ulrich Hersel, Harald Rau, Robert Schnepf, Thomas Wegge
  • Hydrogel formulations
    Patent number: 7968085
    Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: June 28, 2011
    Assignee: Ascendis Pharma A/S
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Protein-proteophore complexes
    Patent number: 7879588
    Abstract: The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: February 1, 2011
    Assignee: Ascendis Pharma A/S
    Inventors: Dirk Vetter, Ulrich Hersel, Harald Rau, Robert Schnepf, Thomas Wegge
  • Polymeric Prodrug with a Self-Immolative Linker
    Publication number: 20080241102
    Abstract: A cascade carrier linked prodrug is described which comprises a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
    Type: Application
    Filed: March 22, 2005
    Publication date: October 2, 2008
    Applicant: COMPLEX BIOSYSTEMS GMBH
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
  • Protein-proteophore complexes
    Publication number: 20070020224
    Abstract: The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
    Type: Application
    Filed: October 1, 2004
    Publication date: January 25, 2007
    Inventors: Dirk Vetter, Ulrich Hersel, Harald Rau, Robert Schnepf, Thomas Wegge
  • Hydrogel formulations
    Publication number: 20060002890
    Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
    Type: Application
    Filed: October 7, 2004
    Publication date: January 5, 2006
    Inventors: Ulrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge