Abstract: A radio frequency locator system and method. First, second and third reference devices are operable to transmit a plurality of spread spectrum chirp signals frequency offset from one another. An object device is operable to receive the plurality of spread spectrum chirp signals, the object device is further operable to evaluate the received plurality of spread spectrum chirp signals for relative phase shifts between the plurality of spread spectrum chirp signals and derive a fine propagation time between the reference devices and the object device using the phase shifts between the spread spectrum chirp signals. The reference devices determine their location independent of the object device and determine the location of the object device as a function of each of their locations and of their range to the object device.

Abstract: Elongated conductors are provided. Aspects of the elongated conductors include: an elongated structure having a proximal region and a distal region, where the elongated conductor includes two or more insulated conducting members that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region to the distal region. A pattern of insulation openings among the insulated conducting members is present at one or both of the proximal and distal regions. Aspects of the invention further include methods of making the elongated conductors, as well as devices that include the elongated conductors.

Abstract: A catheter system for controlled sympathectomy procedures is disclosed. A catheter system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed.

Abstract: A method of improving the health of hair emerging from a scalp comprising application of a composition to reduce oxidative stress in the scalp causing reduced oxidative stress in pre-emergent hair resulting in healthier emergent hair having reduced water absorption and reduced surface energy

Abstract: A catheter system for controlled sympathectomy procedures is disclosed. A catheter system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed.

Abstract: A unique piping arrangement of a water pump system is designed to prevent backflow of non-potable liquid into a potable water source thereby complying with plumbing codes to provide a safe cross connection. These codes are required when a water ejector uses pressurized potable water as an energy source. When the water ejector valve is open due to a high sump level and when the potable water pressure drops below atmospheric, the non-potable liquid can be siphoned into the potable water source thereby causing contamination, a significant unsafe health hazard to consumers. The present invention complies with plumbing codes by creating the required vertical air gap from the potable water source down to the non-potable liquid in the discharge piping as well as the inlet piping, the sources of contamination. In the piping arrangement are vents and drains to create the required air gap and transparent piping to provide required inspection and verification of proper operation.

Abstract: A decorative bar, configured to be mounted on a surface (wall or floor) of a room or building, comprises (a) an elongate rod formed of natural stone and having a substantially constant cross-sectional shape from a first end to an opposite, second end and a longitudinal groove extending along one side, and (b) an elongate metal armature or brace having a portion thereof inserted in and substantially filling the longitudinal groove in the stone rod. The metal brace has a flange or bracket at each end configured to be attached to the surface (wall or floor) of a building to affix and retain the stone rod in a mounted relationship to this surface with its longitudinal groove on a side which is not readily visible to a casual observer.

Abstract: The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve—i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.

Abstract: A scalp care composition directed to a scalp care composition comprising from about 0.05% to about 5% of an anti-dandruff active, from about 0.1% to about 25% of one or more organic solvents, from about 1% to about 99% of a volatile carrier wherein the anti-dandruff active is soluble in the scalp care composition.

Abstract: Elongated conductors are provided. Aspects of the elongated conductors include: an elongated structure having a proximal region and a distal region, where the elongated conductor includes two or more insulated conducting members that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region to the distal region. A pattern of insulation openings among the insulated conducting members is present at one or both of the proximal and distal regions. Aspects of the invention further include methods of making the elongated conductors, as well as devices that include the elongated conductors.

Abstract: A method of improving the health of hair emerging from a scalp comprising a reduction of oxidative stress in the scalp by application of a composition resulting in reduction in oxidative stress in pre-emergent hair as demonstrated by reduced oxidative stress in emergent hair.

Abstract: The present disclosure describes the role for miR-322(424)/503 in the differentiation of cardiac precursor cells. Thus, the use of these molecules in the programming of resident stem/progenitor cells into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve—i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.

Abstract: A scalp care composition comprising from 1% to 99% of a volatile carrier; from 0.05% to 10% of a polymeric rheology modifier and mixtures thereof; from 0.03% to 1% of particulate scalp benefit agent wherein the composition is shear thinning and has (1) a zero shear viscosity value measured at 0.01 Pa of greater than about 1,500 Pa s; (2) a moderate stress viscosity value measured at 1 Pa viscosity of greater than about 1,000 Pa s; and (3) a high shear rate viscosity value measured at 100 l/s of less than about 0.5 Pa s.

Abstract: A package including an intimate cleansing product, a deodorant composition, and in some cases a razor is disclosed herein. The deodorant composition includes an anti-irritation agent. The intimate cleansing product, deodorant composition and razor are co-packaged together. Or, the intimate cleansing product and the deodorant composition are co-packaged together.

Abstract: Systems and methods are provided for automatically configuring an email client during a migration process. An client-side assistant can be deployed to an end-user's computer via a migration platform. After being deployed to a particular client computer, the client-side assistant can be configured to obtain user information to identify the end-user associated with the client computer. After identifying the end-user, destination system information regarding the end-user can be pushed to client computer for inclusion in new configuration information for the email client. Before generating the new configuration information, user credential for logging into the source system can be obtained. The client-side assistant can be configured to cause the destination system to confirm this credential. After generating the new configuration information, the client-side assistant can instruct the client-side assistant to use the new configuration information to at a specific time and date.