Patents by Inventor Robert Scott Thies

Robert Scott Thies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CARDIOMYOCYTE TRANSPLANTATION
    Publication number: 20240122990
    Abstract: The present disclosure provides for the treatment of cardiac diseases and disorders using in vitro-differentiated cardiomyocytes. Such methods can take advantage of both autologous and allogeneic pluripotent stem cells.
    Type: Application
    Filed: February 22, 2022
    Publication date: April 18, 2024
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. MURRY, William Robb MACLELLAN, Robert Scott THIES, Kenta NAKAMURA, Daisy Sue NAKAMURA, Lauren E. NEIDIG
  • PRE-TREATING CARDIOMYOCYTES WITH ANTI-ARRHYTHMIC DRUGS TO REDUCE ENGRAFTMENT ARRHYTHMIA
    Publication number: 20230250393
    Abstract: Described herein are methods and compositions for reducing or preventing arrhythmias associated with or caused by transplantation of cardiomyocytes to cardiac tissue. In particular embodiments, the pre-treatment of in vitro-differentiated cardiomyocytes with amiodarone before administration to cardiac tissue for engraftment reduces or prevents engraftment arrhythmias, and/or reduces the need for adjunctive anti-arrhythmia drugs after cell administration.
    Type: Application
    Filed: January 20, 2023
    Publication date: August 10, 2023
    Applicant: University of Washington
    Inventors: Charles E. MURRY, William Robb MACLELLAN, Robert Scott THIES, Kenta NAKAMURA
  • METHODS OF TREATING AND PREVENTING ENGRAFTMENT ARRHYTHMIAS
    Publication number: 20230077983
    Abstract: Described herein are methods and compositions related to treating and preventing an engraftment arrhythmia with an effective amount of amiodarone and ivabradine. Also described herein is a method of cardiomyocyte transplant, the method comprises: dministering in vitro-differentiated cardiomyocytes to cardiac tissue of a subject in need thereof; and administering to the subject an amount of amiodarone and an amount of ivabradine effective to reduce engraftment arrhythmia in the subject.
    Type: Application
    Filed: February 9, 2021
    Publication date: March 16, 2023
    Applicants: UNIVERSITY OF WASHINGTON, VANDERBILT UNIVERSITY
    Inventors: Robert Scott THIES, William Robb MACLELLAN, Kenta NAKAMURA, Charles E. MURRY, Bjorn KNOLLMANN
  • IMMUNOSUPPRESSIVE THERAPIES FOR USE WITH CARDIOMYOCYTE CELL THERAPIES, AND ASSOCIATED METHODS AND COMPOSITIONS
    Publication number: 20220296572
    Abstract: Provided are methods and uses related to cardiomyocyte cell therapies involving the administration of immunosuppressive agents for reducing or preventing rejection of administered allogeneic cardiomyocytes. In some embodiments, the methods are for treating a subject with a heart disease or condition in combination with a cardiomyocyte cell therapy.
    Type: Application
    Filed: March 2, 2022
    Publication date: September 22, 2022
    Applicant: Sana Biotechnology, Inc.
    Inventors: Robert Scott THIES, Charles E. MURRY
  • Small molecule compounds to treat hearing loss
    Patent number: 9370510
    Abstract: The invention is directed, in part, to compositions comprising small molecule compounds to treat or prevent hearing loss. Compositions of the present invention also promote sensory hair cell regeneration. Particular compositions comprise ellipticine derivatives, and optionally one or more small molecules that increase Atoh1 expression or activity, and optionally one or more growth factors.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 21, 2016
    Assignee: Fate Therapeutics, Inc.
    Inventors: Robert Scott Thies, Francine Farouz, Zhiyong Wang, Chin-Chun Jean Lu
  • COMPOUNDS TO TREAT HEARING LOSS
    Publication number: 20150126507
    Abstract: The invention is directed, in part, to compounds of structure (I) to treat or prevent hearing loss. Compounds of the present invention also promote sensory hair cell regeneration. Particular compositions comprise compounds of structure (I), and optionally one or more small molecules that increase the proliferation of supporting cells.
    Type: Application
    Filed: September 5, 2014
    Publication date: May 7, 2015
    Inventors: Robert Scott Thies, Zhiyong Wang, Bonnie Jacques, Chin-Chun Jean Lu
  • SMALL MOLECULE COMPOUNDS TO TREAT HEARING LOSS
    Publication number: 20150025096
    Abstract: The invention is directed, in part, to compositions comprising small molecule compounds to treat or prevent hearing loss. Compositions of the present invention also promote sensory hair cell regeneration. Particular compositions comprise ellipticine derivatives, and optionally one or more small molecules that increase Atoh1 expression or activity, and optionally one or more growth factors.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 22, 2015
    Inventors: Robert Scott Thies, Francine Farouz, Zhiyong Wang, Chin-Chun Jean Lu