Patents by Inventor Robert Sebra

Robert Sebra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanopore sequencing devices and methods
    Patent number: 8986928
    Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: March 24, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Benjamin Flusberg, Mathieu Foquet, Hans Callebaut, Robert Sebra, Bidhan Chaudhuri, Jon Sorenson, Keith Bjornson, Adrian Fehr, Jonas Korlach, Robin Emig
  • Single molecule loading methods and compositions
    Patent number: 8906831
    Abstract: Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size confined regions such as wells. Sizing moieties are linked to individual target molecules. The sizing moieties are of sufficient size, relative to the size-confined reaction or observation regions, such that only a selected number of sizing moieties will fit into the size confined regions. The confined regions and the sizing moieties or target molecules comprise a selected charge that allow for controlling the loading of the sizing moities.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: December 9, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: John Eid, Stephen Turner, Ravi Dalal, Benjamin Flusberg, Jonas Korlach, Steven Lin, Adrian Fehr, Fred Christians, Robin Emig, Jeremy Gray, Robert Sebra, Lei Sun, Stephen Dudek
  • Selectively Functionalized Arrays
    Publication number: 20130296195
    Abstract: Methods, substrates, and devices related to arrays of optical confinements having surfaces with high levels of bias. Substrates having transparent or silica based portions and opaque or reflective portions are treated with 1) a selective passivating agent, that selectively coats the opaque or reflective regions, 2) a functionalizing agent such as a coupling agent, and 3) a selective removal agent, which selectively removes functionalizing agent from the passivated opaque or reflective surfaces.
    Type: Application
    Filed: June 28, 2013
    Publication date: November 7, 2013
    Inventors: Jeremy Gray, Ronald Cicero, Gregory Kearns, Stephen Dudek, Natasha Popovich, Robert Sebra
  • Selectively functionalized arrays
    Patent number: 8501406
    Abstract: Methods, substrates, and devices related to arrays of optical confinements having surfaces with high levels of bias. Substrates having transparent or silica based portions and opaque or reflective portions are treated with 1) a selective passivating agent, that selectively coats the opaque or reflective regions, 2) a functionalizing agent such as a coupling agent, and 3) a selective removal agent, which selectively removes functionalizing agent from the passivated opaque or reflective surfaces.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: August 6, 2013
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jeremy Gray, Ronald Cicero, Gregory Kearns, Stephen Dudek, Natasha Popovich, Robert Sebra
  • NANOPORE SEQUENCING DEVICES AND METHODS
    Publication number: 20100331194
    Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
    Type: Application
    Filed: April 9, 2010
    Publication date: December 30, 2010
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Benjamin Flusberg, Mathieu Foquet, Hans Callebaut, Robert Sebra, Bidhan Chaudhuri, Jon Sorenson, Keith Bjornson, Adrian Fehr, Jonas Korlach, Robin Emig