Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A surgical task trainer is provided to train the novice student in the fundamental skills of vessel anastomosis without the aid of a surgical assistant. The trainer includes (1) a stable base with a non-slip stabilization grip at each end to secure the target artificial blood vessel. Threaded holes within the stable base receive and stabilize (2) a damped adjustable support arm comprising a visco-elastic damping element and a non-slip vessel stabilization grip to stabilize the non-target artificial blood vessel, (3) an adjustable suture thread tensioning assembly to apply adjustable tension to the suture thread, and (4) an adjustable arteriotomy stabilization apparatus to open and stabilize the incision in the target artificial blood vessel.

Abstract: An integrated network receiver includes a first universal resource identifier for a first channel and an input suitable for receiving a first input video content from the Internet based upon the first universal resource identifier. The integrated network receiver provides the first input video content for the first channel to a head end connected to a plurality of customer devices through a transmission network. The integrated network receiver updating the first universal resource identifier based upon data obtained from a video address server.

Abstract: A bow may have a string latch that holds a bowstring and that can be moved into three distinct positions. One activator may be used to prevent the string latch from being moved into its second position. A second activator may be used to prevent the string latch from being moved into its third position. A third activator may be used to move the first and second activators to prevent the string latch from being moved into its second or third positions.

Abstract: A bow may have a string latch that holds a bowstring and that can be moved into three distinct positions. One activator may be used to prevent the string latch from being moved into its second position. A second activator may be used to prevent the string latch from being moved into its third position. A third activator may be used to move the first and second activators to prevent the string latch from being moved into its second or third positions.

Abstract: An integrated network receiver includes a first universal resource identifier for a first channel and an input suitable for receiving a first input video content from the Internet based upon the first universal resource identifier. The integrated network receiver provides the first input video content for the first channel to a head end connected to a plurality of customer devices through a transmission network. The integrated network receiver updating the first universal resource identifier based upon data obtained from a video address server.

Abstract: An integrated network receiver includes a first universal resource identifier for a first channel and an input suitable for receiving a first input video content from the Internet based upon the first universal resource identifier. The integrated network receiver provides the first input video content for the first channel to a head end connected to a plurality of customer devices through a transmission network. The integrated network receiver updating the first universal resource identifier based upon data obtained from a video address server.

Abstract: A crossbow de-cock mechanism may include a de-cock activator that is selectively movable from a first de-cock activator position that prevents de-cocking of a crossbow into a second de-cock activator position that permits de-cocking of the crossbow.

Abstract: A crossbow may include a bowstring and a string latch that can be moved into a first string latch position that holds the bowstring in a cocked position, a second string latch position that does not hold the bowstring in the cocked position and a third string latch position. To de-cock the crossbow, a de-cock activator may be selectively movable from a first de-cock activator position that prevents the string latch from being moved into the third string latch position into a second de-cock activator position that permits the string latch to be moved into the third string latch position. When the string latch is in the first string latch position and the de-cock activator is in the second de-cock activator position: the string latch may be selectively movable into the third string latch position and then the second string latch position permitting de-cocking of the crossbow.

Abstract: A crossbow de-cock mechanism may include a de-cock activator that is selectively movable from a first de-cock activator position that prevents de-cocking of a crossbow into a second de-cock activator position that permits de-cocking of the crossbow.

Abstract: A crossbow de-cock mechanism may include a de-cock activator that is selectively movable from a first de-cock activator position that prevents de-cocking of a crossbow into a second de-cock activator position that permits de-cocking of the crossbow.

Abstract: A crossbow reset mechanism may be used to reset a safety activator and a de-cock activator. The reset mechanism may reset the safety and de-cock activators simultaneously.

Abstract: A crossbow may include two bowstring guides engaged on first and second sides of the crossbow barrel. The bowstring guides may push the bowstring toward opposite sides of the barrel when the bowstring is moved from the fully uncocked position to the fully cocked position and when the bowstring is moved from the fully cocked position to the fully uncocked position.

Abstract: An integrated network receiver includes a first universal resource identifier for a first channel and an input suitable for receiving a first input video content from the Internet based upon the first universal resource identifier. The integrated network receiver provides the first input video content for the first channel to a head end connected to a plurality of customer devices through a transmission network. The integrated network receiver updating the first universal resource identifier based upon data obtained from a video address server.

Abstract: A crossbow reset mechanism may be used to reset a safety activator and a de-cock activator. The reset mechanism may reset the safety and de-cock activators simultaneously.

Abstract: A crossbow de-cock mechanism may include a de-cock activator that is selectively movable from a first de-cock activator position that prevents de-cocking of a crossbow into a second de-cock activator position that permits de-cocking of the crossbow.

Abstract: A crossbow reset mechanism may be used to reset a safety activator and a de-cock activator. The reset mechanism may reset the safety and de-cock activators simultaneously.

Abstract: A crossbow de-cock mechanism may include a de-cock activator that is selectively movable from a first de-cock activator position that prevents de-cocking of a crossbow into a second de-cock activator position that permits de-cocking of the crossbow.

Abstract: A crossbow may include two bowstring guides engaged on first and second sides of the crossbow barrel. The bowstring guides may push the bowstring toward opposite sides of the barrel when the bowstring is moved from the fully uncocked position to the fully cocked position and when the bowstring is moved from the fully cocked position to the fully uncocked position.

Abstract: Provided is a crossbow comprising an elongated barrel having a front barrel end and a rear barrel end opposite the front barrel end, and a first barrel side and a second barrel side opposite the first barrel side; a bow engaged with the elongated barrel; an elongated bowstring having a first end and a second end opposite the first end; a first bowstring guide engaged with the first barrel side, the first bowstring guide being adapted to push the bowstring toward the second barrel side while the bowstring is moved between a cocked position and an uncocked position; and a second bowstring guide engaged with the second barrel side, the second bowstring guide being adapted to push the bowstring toward the first barrel side while the bowstring is moved between a cocked position and an uncocked position.