Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: Digitally controlled segmented RF power transmitter with a digital processing part (2) and an RF power amplification part (3) having a plurality of segments (122). The digital processing part (2) has a clock generation block (5) being arranged to generate n equi-phased clock signals with a 50% duty-cycle (fLO,x_50%; Cx), and a sign-bit phase mapper unit (11) being arranged to receive the n equi-phased clock signals (fLO,x_50%; Cx), and sign signals (SignI, SignQ; sign bits), and to output a set of m, m?n, phase mapped clock signals with a 50% duty-cycle (CLKy,50%; Cy) using a predetermined phase swapping scheme. Each of the plurality of segments (122) comprises logic circuitry (12) receiving the set of m phase-mapped clock signals with a 50% duty-cycle (CLKy,50%; Cy), and being arranged to provide the respective segment driving signal with a duty-cycle z of less than 50%.

Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

Abstract: A method for a crawl algorithm includes obtaining a plurality of web pages for a web crawler to crawl. The method also includes determining an available bandwidth for the web crawler. The method includes, for each respective web page of the plurality of web pages, determining a respective crawl value for the respective web page based on the available bandwidth and determining that the respective crawl value of the respective web page satisfies a threshold value. The method includes, in response to determining that the respective crawl value of the respective web page satisfies the threshold value, updating the respective web page in a cache memory.

Abstract: Method and systems for identifying and distinguishing subjects using a detection system comprising pooled probes are described. The pooled probes described comprise subject specific features allowing for identification and distinction of subjects in a complex sample and can be utilized in a variety of detection platforms. The methods and systems can further comprise the use of isotachophoresis to concentrate analytes in a sample.

Abstract: Described herein are conductive elastomeric foam materials and methods of making and using the same. The conductive elastomeric foam materials include a polymeric matrix, one or more conductive fillers, and one or more foaming agents. The polymeric matrix can include a thermoset polymer or a thermoplastic polymer. Also described herein are methods of making conductive elastomeric foam materials. Further described herein are molded products including the conductive elastomeric foam materials as described herein and wearable devices including the molded products.

Abstract: An active stylus includes a stylus tip assembly and an elongate housing enclosing a portion of the stylus tip assembly. A winged bracket mounted within the elongate housing and affixed to a tip-distal end of the stylus tip assembly is configured to flex in response to pressure applied to the stylus tip assembly. A strain gauge disposed along the winged bracket is configured to measure strain along the winged bracket caused by pressure applied to the tip assembly.

Abstract: An active stylus includes a stylus tip assembly and an elongate housing enclosing a portion of the stylus tip assembly. A winged bracket mounted within the elongate housing and affixed to a tip-distal end of the stylus tip assembly is configured to flex in response to pressure applied to the stylus tip assembly. A strain gauge disposed along the winged bracket is configured to measure strain along the winged bracket caused by pressure applied to the tip assembly.

Abstract: An active stylus includes a stylus tip assembly and an elongate housing enclosing a portion of the stylus tip assembly. A winged bracket mounted within the elongate housing and affixed to a tip-distal end of the stylus tip assembly is configured to flex in response to pressure applied to the stylus tip assembly. A strain gauge disposed along the winged bracket is configured to measure strain along the winged bracket caused by pressure applied to the tip assembly.

Abstract: A solid or semi-solid pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

Abstract: The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated aspirin active ingredient, and preferably a lightly compressed matrix comprising directly compressible carbohydrate(s) and at least one sweetener.

Abstract: Phenylephrine particles suitable for solid, semi solid or liquid dosage forms are disclosed.

Abstract: The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated aspirin active ingredient, and preferably a lightly compressed matrix comprising directly compressible carbohydrate(s) and at least one sweetener.

Abstract: A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

Abstract: The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated aspirin active ingredient, and preferably a lightly compressed matrix comprising directly compressible carbohydrate(s) and at least one sweetener.

Abstract: A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

Abstract: The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid.

Abstract: The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated granule comprising an intimate mixture of an aspirin active ingredient and at least one binder capable of preferentially absorbing ambient moisture.

Abstract: The present invention features a method of manufacturing an osmotic tablet including the steps of (i) compressing a tablet core including a first pharmaceutically active agent and a hydrophilic polymer; (ii) applying an osmotic coating to the outer surface of the tablet core to form a coated tablet, wherein the osmotic coating includes at least one opening exposing the tablet core; and (iii) compressing an immediate release coating onto the surface of the coated tablet, wherein the release coating includes a second pharmaceutically active agent.

Abstract: The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid.