Abstract: The invention provides improved compositions for adoptive cell therapies for cancers that express ROR1.

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.

Abstract: Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis.

Abstract: Provided herein are uses of fibroblast growth factor receptor 2 (FGFR2) inhibitors in cancer treatment, in some cases in combination with immune stimulating agents, such as inhibitors of PD-1 or PD-L1. In some embodiments, FGFR2 inhibitors may comprise FGFR2 antibodies or FGFR2 extracellular domain (ECD) polypeptides, or FGFR2 ECD fusion molecules comprising an FGFR2 ECD and a fusion partner. In some embodiments, PD-1/PD-L1 inhibitors may comprise anti-PD-1 antibodies such as antibodies that bind to PD-1 or to PD-L1 and inhibit interactions between these proteins, as well as PD-1 fusion proteins or polypeptides. This application also provides methods of predicting response to treatment of cancer, such as bladder or gastric cancer, with FGFR2 inhibitors by determining FGFR2 overexpression and/or gene amplification in tumor cells of cancer subjects before treatment with FGFR2 inhibitors either alone or in combination with immune stimulating agents.

Abstract: Provided herein are uses of fibroblast growth factor receptor 2 (FGFR2) inhibitors in cancer treatment, in some cases in combination with immune stimulating agents, such as inhibitors of PD-1 or PD-L1. In some embodiments, FGFR2 inhibitors may comprise FGFR2 antibodies or FGFR2 extracellular domain (ECD) polypeptides, or FGFR2 ECD fusion molecules comprising an FGFR2 ECD and a fusion partner. In some embodiments, PD-1/PD-L1 inhibitors may comprise anti-PD-1 antibodies such as antibodies that bind to PD-1 or to PD-L1 and inhibit interactions between these proteins, as well as PD-1 fusion proteins or polypeptides.

Abstract: This application provides methods of treating cancer and/or inhibiting angiogenesis with an anti-Ang2 antibody or functional part thereof either alone or in combination with at least one additional therapeutic agent.

Abstract: Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.

Abstract: A loader coupling system includes an arm coupler and a link coupler. The arm coupler includes first and second plunger pins located respectfully at opposite first and second ends of the body. At least one plunger actuator is operatively connected to the first and second plunger pins, and the plunger actuator is selectively operative to move the first and second plunger pins between a retracted position and an extended position. The link coupler includes a tilt link with a first end adapted to be pivotally connected to a control link of the associated loader machine and a second end including a hook adapted to selectively engage and retain a cross-pin of the associated attachment. A lock system is connected to the tilt link and is adapted to selectively capture the cross-pin of the associated attachment in the hook.

Abstract: A fork apparatus includes a body adapted to be operatively connected to an associated loader machine. First and second forks include respective first and second fork mounting portions connected to the body and respective first and second fork working portions that project outwardly away from the body. A first powered roller device is connected to the first fork and includes a first roller that rotates about a first working portion axis. A first roller actuator selectively rotates the first roller about the first working portion axis. A second powered roller device is connected to the second fork and includes a second roller that rotates about the second working portion axis that is parallel to the first working portion axis. A second roller actuator selectively rotates the second roller about the second working portion axis.

Abstract: A coupler for a backhoe or other excavator includes a frame including an upper portion and a lower portion. The upper portion is adapted to be secured to an associated backhoe or excavator arm. The lower portion includes a first hook adapted to mate releasably with a first associated attachment pin and includes a second hook adapted to mate releasably with a second associated attachment pin. First and second safety locks are movably connected to the frame and move relative to the first hook between an engaged position for capturing the first associated attachment pin in the first hook and a disengaged position for releasing the first associated attachment pin from the first hook. An actuator is adapted to move the safety locks selectively between the engaged and disengaged positions.

Abstract: A loader coupler includes a body with spaced-apart inner rib mounts for mating respectively with ribs of a first type of attachment. The body also includes inner locking regions that are aligned with the inner rib mounts. Spaced-apart outer rib mounts are also provided on the body and are adapted to mate respectively with a second type of attachment. Outer locking regions are aligned with the outer rib mounts. A lock system is connected to the body and includes: (i) a first actuator operatively connected to left and right first lock plungers and adapted to move the left and right first lock plungers between locked and unlocked positions; and, (ii) a second actuator operatively connected to left and right second lock plungers and adapted to move the left and right second lock plungers between locked and unlocked positions.

Abstract: A loader coupling system includes an arm coupler and a link coupler. The arm coupler includes first and second plunger pins located respectfully at opposite first and second ends of the body. At least one plunger actuator is operatively connected to the first and second plunger pins, and the plunger actuator is selectively operative to move the first and second plunger pins between a retracted position and an extended position. The link coupler includes a tilt link with a first end adapted to be pivotally connected to a control link of the associated loader machine and a second end including a hook adapted to selectively engage and retain a cross-pin of the associated attachment. A lock system is connected to the tilt link and is adapted to selectively capture the cross-pin of the associated attachment in the hook.

Abstract: A coupler includes a frame with a front hook and a rear hook. A rear hook lock moves between an unlocked position and a locked position, wherein the rear hook lock obstructs an open mouth of the rear hook when the rear hook lock is in its locked position. An actuator is connected to the frame and is operatively connected to the rear hook lock. The actuator is adapted to move the rear hook lock between its unlocked and locked positions. A secondary lock includes a latch that moves between extended and retracted positions, wherein the latch obstructs an open mouth of the front hook when the latch is in its extended position.

Abstract: A loader coupler includes a body with spaced-apart inner rib mounts for mating respectively with ribs of a first type of attachment. The body also includes inner locking regions that are aligned with the inner rib mounts. Spaced-apart outer rib mounts are also provided on the body and are adapted to mate respectively with a second type of attachment. Outer locking regions are aligned with the outer rib mounts. A lock system is connected to the body and includes: (i) a first actuator operatively connected to left and right first lock plungers and adapted to move the left and right first lock plungers between locked and unlocked positions; and, (ii) a second actuator operatively connected to left and right second lock plungers and adapted to move the left and right second lock plungers between locked and unlocked positions.

Abstract: A loader coupling system includes an arm coupler and a link coupler each adapted to mate with an associated attachment. The arm coupler includes a body adapted to be connected to and extend between first and second spaced-apart arms of an associated loader machine. First and second plunger pins are located respectfully at opposite first and second ends of the body. At least one plunger actuator is operatively connected to the first and second plunger pins, and the at least one plunger actuator is selectively operative to move the first and second plunger pins between a retracted position and an extended position.

Abstract: A sweeper apparatus includes a brush frame with first and second sides and a top surface. A brush roll is supported on the brush frame and is adapted for rotation to dislodge snow or other debris from an associated surface. A brush hood is connected to the brush frame and includes a hood surface located between the top surface and the brush roll. The hood surface extends between the first and second lateral sides of the brush frame and is selectively movable between an up position and a down position. A stripper bar is connected to the brush hood and is movable with the hood surface when the hood surface moves between its down and up positions. At least one actuator is operably connected between the brush frame and the brush hood and is selectively operable to move the hood surface between its up and down positions.

Abstract: A grapple apparatus for handling cotton modules includes a frame comprising first and second portions. The second portion is selectively movable relative to the first portion between an opened position and a closed position. The frame defines a module-holding space when the second portion of the frame is in its closed position. At least one powered roller device is connected to the frame and is selectively active to rotate an associated cotton module located in the module-holding space relative to said frame about a module axis of rotation. A method for handling cotton modules includes positioning a frame adjacent a cotton module and moving a second portion of the frame relative to a first portion of the frame from an opened position to a closed position to define a module-holding space in which the cotton module is received and retained.

Abstract: A loader coupler includes a body with spaced-apart inner rib mounts for mating respectively with ribs of a first type of attachment. The body also includes inner locking regions that are vertically aligned with the inner rib mounts. Spaced-apart outer rib mounts are also provided on the body and are adapted to mate respectively with a second type of attachment. Outer locking regions are vertically aligned with the outer rib mounts. A lock system is connected to the body and includes: (i) a first actuator operatively connected to left and right first lock plungers and adapted to move the left and right first lock plungers between locked and unlocked positions; and, (ii) a second actuator operatively connected to left and right second lock plungers and adapted to move the left and right second lock plungers between locked and unlocked positions.