Patents by Inventor Robert Smakman
Robert Smakman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12165836Abstract: Systems and methods of profiling a charged-particle beam are disclosed. The method of profiling a charged-particle beam may comprise activating a charged-particle source to generate the charged-particle beam along a primary optical axis, modifying the charged-particle beam by adjusting an interaction between the charged-particle beam and a standing optical wave, detecting charged particles from the modified charged-particle beam after the interaction with the standing optical wave, and determining a profile of the charged-particle beam based on the detected charged particles. Alternatively, the method may include activating an optical source, modifying the optical beam by adjusting an interaction between the optical beam and a charged-particle beam, detecting an optical signal from the modified optical beam, and determining a characteristic of the charged-particle beam based on the detected optical signal.Type: GrantFiled: October 15, 2020Date of Patent: December 10, 2024Assignee: ASML Netherlands B.V.Inventors: Maikel Robert Goosen, Erwin Paul Smakman
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Publication number: 20230201799Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: ApplicationFiled: February 10, 2023Publication date: June 29, 2023Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Patent number: 11612877Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: GrantFiled: December 4, 2018Date of Patent: March 28, 2023Assignees: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20230046628Abstract: The present invention relates to a method for preparing a macromolecular composition comprising phenylglyoxaldehyde-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules, for instance to remove such small molecules from a solution.Type: ApplicationFiled: November 20, 2020Publication date: February 16, 2023Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20220401889Abstract: The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.Type: ApplicationFiled: November 20, 2020Publication date: December 22, 2022Applicants: Stichting voor de Technische Wetenschappen, UMC Utrecht Holding B.V., Universiteit Utrecht Holding B.V., Universiteit TwenteInventors: Dimitrios Stamatialis, Ilaria Geremia, Cornelus Franciscus van Nostrum, Karin Gerarda Frederika Gerritsen, Robert Smakman, Wilhelmus Everhardus Hennink, Jacobus Adrianus Wilhelmus Jong, Yong Guo
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Publication number: 20200368721Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: ApplicationFiled: December 4, 2018Publication date: November 26, 2020Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20090223899Abstract: Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.Type: ApplicationFiled: May 13, 2009Publication date: September 10, 2009Applicants: Baxter International Inc., Baxter Healthcare S.A.Inventors: Mitchell J. Poss, Henk Blom, Alex Odufu, Robert Smakman
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Publication number: 20090218290Abstract: Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.Type: ApplicationFiled: May 13, 2009Publication date: September 3, 2009Applicants: Baxter International Inc., Baxter Healthcare S.A.Inventors: Mitchell J. Poss, Henk Blom, Alex Odufu, Robert Smakman
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Patent number: 7544737Abstract: Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.Type: GrantFiled: November 12, 2004Date of Patent: June 9, 2009Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Mitchell J. Poss, Henk Blom, Alex Odufu, Robert Smakman
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Publication number: 20050131141Abstract: Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.Type: ApplicationFiled: November 12, 2004Publication date: June 16, 2005Inventors: Mitchell Poss, Henk Blom, Alex Odufu, Robert Smakman
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Patent number: 6861473Abstract: Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.Type: GrantFiled: February 28, 2003Date of Patent: March 1, 2005Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Mitchell J. Poss, Henk Blom, Alex Odufu, Robert Smakman
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Publication number: 20040171754Abstract: Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.Type: ApplicationFiled: February 28, 2003Publication date: September 2, 2004Inventors: Mitchell J. Poss, Henk Blom, Alex Odufu, Robert Smakman
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Patent number: 6379294Abstract: A process for preparing an esterquat composition comprising (a) reacting a tertiary amine according to formula I: wherein R1 represents a C3-C6 hydrocarbon group, R2 represents a C3-C6 hydrocarbon group, a —R4—OH group or a —CH2[CH(OH)]nCH2OR5 group, if R2 represents a C3-C6 hydrocarbon group, R3 represents a —R4—OH group or a —CH2[CH(OH)]nCH2OR5 group, if R2 represents a —R4—OH group, R3 represents a —R4—OH group or a —CH2[CH(OH)]nCH2OR5 group, if R2 represents a —CH2[CH(OH)]nCH2OR5 group, R3 represents a —CH2[CH(OH)]nCH2OR5 group, R4 represents a C2-C4 hydrocarbon group, n is 1-4, and R5 represents H or a C1-C30 hydrocarbon group, with a C3-C6 hydrocarbyl halide or a di(C3-C6) hydrocarbyl sulfate, followed by (b) reaction with a C8-C30 acid halide, with the proviso that at least one hydroxy group is esterified.Type: GrantFiled: July 19, 2000Date of Patent: April 30, 2002Assignee: Akzo Nobel N.V.Inventors: Adrianus Buijs, Gerardus Van Gurp, Tjitte Nauta, Robert Smakman, Anne Marijke Wit-Van Grootheest
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Patent number: 4897200Abstract: A carbonyl groups containing macromolecular material which is suitable for use as a sorbent for ammonia, urea or amino compounds. It contains structural units having 3 or more, optionally hydrated vicinal carbonyl groups, preferably keto groups, the C-atoms of which may form part of a ring structure. Particularly, the ring structure contains 5-7 C-atoms, and at least 2 ring atoms may form part of an aromatic ring system. The starting material used may be made of a polymer of the same type as that used in the manufacture of ion exchange resins. The carbonyl group containing unit may form part of an independent compound, e.g., ninhydrin which may be physically bonded to the macromolecular material, but is preferably covalently bonded thereto.Type: GrantFiled: November 10, 1986Date of Patent: January 30, 1990Assignee: Organon Teknika bvInventor: Robert Smakman
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Patent number: 4542015Abstract: An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water. Metal salts of iron, aluminum, zirconium, lanthanum, thorium and tin are deposited on a cation exchange material and the charged cation exchange resin is contacted with dialysis liquid. The process of treating blood with the dialysis liquid is also contemplated.Type: GrantFiled: August 19, 1982Date of Patent: September 17, 1985Assignee: Organon Teknika B.V.Inventors: Robert Smakman, Gerrit H. van den Berg
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Patent number: 4213859Abstract: An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water. Metal salts of iron, aluminium, zirconium, lanthanum, thorium and tin are deposited on a cation exchange material and the charged cation exchange resin is contacted with dialysis liquid. The process of treating blood with the dialysis liquid is also contemplated.Type: GrantFiled: April 10, 1978Date of Patent: July 22, 1980Assignee: Akzo N.V.Inventors: Robert Smakman, Gerrit H. van den Berg
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Patent number: 4177140Abstract: A method for removing a weak acid from an aqueous solution containing said acid is disclosed. The method comprises contacting said aqueous solution with an anion exchanger containing both strongly basic and weakly basic groups, said exchanger having a matrix comprising a copolymer of styrene and not more than about 20%, by weight, of a cross-linking agent, from about 3% to about 90% of the total basic groups being strongly basic groups of the quaternary ammonium type having the structure --CH.sub.2 N.sup.+ R.sub.1 R.sub.2 R.sub.3, wherein R.sub.1, R.sub.2, and R.sub.3 are independently selected from the group consisting of --CH.sub.3, --C.sub.2 H.sub.5, and --C.sub.2 H.sub.4 OH, and the balance of the basic groups being weakly basic groups of the tertiary amine type.Type: GrantFiled: January 27, 1978Date of Patent: December 4, 1979Assignee: Akzona Inc.Inventor: Robert Smakman
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Patent number: 4160675Abstract: A process for removing an organic impurity from an aqueous solution is disclosed, said process comprising contacting the aqueous solution with an acid cation exchanger and subsequently with a polymer or polycondensate, which contains sulfur in the form of thiol groups bonded to carbon atoms.Type: GrantFiled: September 12, 1977Date of Patent: July 10, 1979Assignee: Akzona IncorporatedInventors: Wilhelmus Pannekeet, Robert Smakman
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Patent number: 4157298Abstract: Ferric ions are removed from a concentrated aqueous zinc solution having a pH value in the range of about 0 to about 1.3, by contacting the zinc solution with a cation exchange chelate resin containing aminocarboxylic acid and/or iminodicarboxylic acid groups.Type: GrantFiled: December 23, 1977Date of Patent: June 5, 1979Assignee: Akzona IncorporatedInventors: Gerrit H. van den Berg, Wilhelmus Pannekeet, Kees Koerts, Robert Smakman