Abstract: Systems and methods for camera sensor correction are disclosed. In an exemplary embodiment, a method may include sampling a spectral response for a plurality of color channels at different spatial locations on a sensor. The method may also include applying a 4×4 color correction matrix at the different spatial locations in an image captured by the sensor. The method may also include converting the spectral response at each spatial location to match the spectral response of the sensor at any one location on the image.

Abstract: In one embodiment, a method for a multiplexed continuous biomarker clinical trial is disclosed that evaluates multiple drugs concurrently or subsequently against a continuously collected and enlarging control group with increasing statistical power.

Abstract: A method is provided for correcting a captured image. The method comprises determining an illuminant for the captured image. When the determined illuminant matches a reference illuminant the image is corrected with a reference inversion mask. When the determined illuminant matches a first extreme illuminant, the reference inversion mask is modified using a first set of reference point ratios that corresponds to the first extreme illuminant and the image is corrected with the modified inversion mask. When the determined illuminant does not match the first extreme illuminant, a set of reference point ratios are calculated for the determined illuminant. The reference inversion mask is modified using the calculated set of reference point ratios and the image is corrected with the modified inversion mask.

Abstract: The present invention relates to the use of p53 gene therapy to treat recurrent cancers in combination with a radio- or chemotherapy. Patients with recurring cancers are treated with a p53 expression construct followed by subsequent radio- or chemotherapy treatment. Viral and non-viral delivery systems, as well as various radio- and chemotherapy regimens are disclosed.

Abstract: A method is provided for correcting a captured image. The method comprises determining an illuminant for the captured image. When the determined illuminant matches a reference illuminant the image is corrected with a reference inversion mask. When the determined illuminant matches a first extreme illuminant, the reference inversion mask is modified using a first set of reference point ratios that corresponds to the first extreme illuminant and the image is corrected with the modified inversion mask. When the determined illuminant does not match the first extreme illuminant, a set of reference point ratios are calculated for the determined illuminant. The reference inversion mask is modified using the calculated set of reference point ratios and the image is corrected with the modified inversion mask.

Abstract: The present invention relates to the identification of various prognostic factors that predict response in patients with hyperproliferative disease such as cancer to gene therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy. Also described are methods of treatment for Li Fraumeni syndrome, and for assessing anti-cancer gene therapy using PET scans.

Abstract: Compositions and methods for preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid comprised in a solid or semi-solid formation or in a transdermal or transcutaneous delivery device are disclosed. Also disclosed are compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include an adhesive. Compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid uptake enhancer are also disclosed. Methods of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that involve these therapeutic compositions and devices are also disclosed.

Abstract: An electronic image capture device including an image capture array, an optional image stabilization gyro, a processor, and a display is configured to detect the amount shaking of the device either prior to, or during image capture. When the shaking of the device exceeds a threshold required for the capture of quality images, the user of the image capture device is notified through the display that excessive shake has been detected and may be advised on methods to reduce or eliminate the shake.

Abstract: Multiple uncompressed digital images, each at a different exposure, may be captured automatically in response to an image capture request. The set of uncompressed digital images may be stored as a single data object and manipulated to produce a final digital image.

Abstract: Digital image processing methods, digital image devices and articles of manufacture are described. According to one aspect, a digital image processing method includes providing digital image data of a plurality of colors of an image, wherein the image data comprises a plurality of sets individually comprising mosaic data of one of a plurality of colors at a plurality of pixel locations, analyzing image data of one of the pixel locations with respect to image data of another of the pixel locations, and adjusting the image data of the one pixel location responsive to the analyzing, wherein the adjusting comprises adjusting to one of denoise the image data and sharpen the image data.

Abstract: Digital imaging systems, articles of manufacture, and digital image processing methods are described. According to one aspect, a digital imaging system includes an imaging system configured to provide image data of an image, the image data comprising digital image data for a plurality of pixel locations and processing circuitry configured to process the image data provided by the imaging system to denoise and sharpen the image data, wherein the processing circuitry, for an individual one of the pixel locations, is configured to identify a respective subset of the image data corresponding to the one pixel location and perform a single processing operation using the image data of the identified subset of the image data to denoise and sharpen the image data of the individual one pixel location.

Abstract: The present invention provides a system and method for capturing images. Briefly described, one embodiment comprises a digital camera, the digital camera comprising at least a photosensor; and an enclosure configured to receive the digital camera, configured to have at least one feature controlling operation of the digital camera, and configured to capture an image using the photosensor of the digital camera.

Abstract: Disclosed are systems and methods for counteracting lens vignetting. In one embodiment, a system and method pertain to resetting pixels of an image sensor, and reading pixels of the image sensor after they have been reset such that the time between resetting and reading is greater for pixels adjacent edges of the sensor than for pixels adjacent a center of the sensor.

Abstract: A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.

Abstract: A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.