Abstract: An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.

Abstract: An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.

Abstract: An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.

Abstract: A transmission control module comprises an actuation module and a flare control module. The actuation module controls actuation of a friction device used in shifting from a first transmission ratio to a second transmission ratio. The transmission ratio is based on an input speed of a transmission divided by an output speed of the transmission. The first transmission ratio is greater than the second transmission ratio. The flare control module selectively generates an engine torque reduction request when a measured transmission ratio is greater than a threshold during a shift from the first transmission ratio to the second transmission ratio.

Abstract: A vehicle includes a transmission, and an Electronic Transmission Range Selection (ETRS) system. The transmission has a plurality of clutches, a park pawl, and a park sensor. The ETRS system has a controller and an electronic range selector device. The controller is programmed to detect a delay in pull out of the park pawl from a park position and to control an action of the vehicle in response to the delay by receiving an electronic range request signal to shift from a park operating range to another operating range; receiving a park pawl position signal from the park sensor; determining if pull out of the park pawl from the park position has not occurred by a predetermined time; and increasing one of a line pressure, a clutch pressure, and an idle speed if pull out of the park pawl from the park position has not occurred by the predetermined time.

Abstract: A vehicle includes a transmission, and an Electronic Transmission Range Selection (ETRS) system. The transmission has a plurality of clutches, a park pawl, and a park sensor. The ETRS system has a controller and an electronic range selector device. The controller is programmed to detect a delay in pull out of the park pawl from a park position and to control an action of the vehicle in response to the delay by receiving an electronic range request signal to shift from a park operating range to another operating range; receiving a park pawl position signal from the park sensor; determining if pull out of the park pawl from the park position has not occurred by a predetermined time; and increasing one of a line pressure, a clutch pressure, and an idle speed if pull out of the park pawl from the park position has not occurred by the predetermined time.

Abstract: A method and apparatus for selectively storing data on a server. The method operates by accessing a computer file and defining a data block as a current block of data. The current block is subsequently checksummed using a rolling error identification code. The method then determines if the calculated checksum for the current block has been previously stored in a database. If a matching checksum for the data is found in the database, then a duplicate of the current block already exists and the process repeats by selecting a new block of data. Alternatively, if the calculated checksum is absent from the checksum and the process has advanced one block length, the process moves back one block length and stores the current block in an archive. Otherwise, the checksum advances one byte forward to form a new current block of data and the process repeats.

Abstract: An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.

Abstract: A method and apparatus for selectively storing data on a server. The method operates by accessing a computer file and defining a data block as a current block of data. The current block is subsequently checksummed using a rolling error identification code. The method then determines if the calculated checksum for the current block has been previously stored in a database. If a matching checksum for the data is found in the database, then a duplicate of the current block already exists and the process repeats by selecting a new block of data. Alternatively, if the calculated checksum is absent from the checksum and the process has advanced one block length, the process moves back one block length and stores the current block in an archive. Otherwise, the checksum advances one byte forward to form a new current block of data and the process repeats.

Abstract: A control system for a transmission of a vehicle comprises an actuation module and an upshift control module. The transmission has a first gear that corresponds to a first transmission ratio and a second gear that corresponds to a second transmission ratio that is less than the first transmission ratio. The actuation module controls an amount torque transferred to the second gear using a friction device. The upshift control module selectively increases the amount of torque transferred to the second gear based on a comparison of the first transmission ratio and a measured transmission ratio at a predetermined period of time after an upshift to the second gear is commanded, wherein the measured transmission ratio is determined based on an input speed of the transmission divided by an output speed of the transmission.

Abstract: A control system for a transmission of a vehicle comprises an actuation module and an upshift control module. The transmission has a first gear that corresponds to a first transmission ratio and a second gear that corresponds to a second transmission ratio that is less than the first transmission ratio. The actuation module controls an amount torque transferred to the second gear using a friction device. The upshift control module selectively increases the amount of torque transferred to the second gear based on a comparison of the first transmission ratio and a measured transmission ratio at a predetermined period of time after an upshift to the second gear is commanded, wherein the measured transmission ratio is determined based on an input speed of the transmission divided by an output speed of the transmission.

Abstract: A transmission control module comprises an actuation module and a flare control module. The actuation module controls actuation of a friction device used in shifting from a first transmission ratio to a second transmission ratio. The transmission ratio is based on an input speed of a transmission divided by an output speed of the transmission. The first transmission ratio is greater than the second transmission ratio. The flare control module selectively generates an engine torque reduction request when a measured transmission ratio is greater than a threshold during a shift from the first transmission ratio to the second transmission ratio.