Abstract: The disclosed computer-implemented method for restarting computing devices into security-application-configured safe modes may include (1) configuring a security application to recognize a predetermined signal received via a predetermined hardware device that indicates that a user wants to restart the computing device into a security-application-configured safe mode that prevents suspicious applications from loading, (2) detecting the predetermined signal via an instance of the predetermined hardware device that is connected to the computing device, (3) setting, in response to detecting the predetermined signal, a registry key on the computing device that will instruct the computing device to boot into the security-application-configured safe mode during a restart sequence, and (4) restarting the computing device in the security-application-configured safe mode in response to detecting the registry key during the restart sequence. Various other methods, systems, and computer-readable media are also disclosed.