Abstract: Provided are a compound of the formula: (5-(2-(4-((3,5-difluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxylic acid) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the above compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Abstract: Provided are compounds of the Formula I, and salts, hydrates and solvates thereof: wherein R1, Q, Ra, Rb, Rc, Rd and Re are each as defined in the specification. The compounds are inhibitors of Casein Kinase 2 alpha (CK2?) and are useful for the treatment and/or prevention of diseases and conditions in which CK2? activity is implicated, such as, for example, but not limited to, the treatment and/or prevention of proliferative disorders (e.g. cancer), viral infections, inflammation, diabetes, vascular and ischemic disorders, neurodegeneration and the regulation of circadian rhythm. The present invention also relates to pharmaceutical compositions comprising the compounds defined herein, to processes for synthesising these compounds and to their use for the treatment of diseases and/or conditions in which CK2? activity is implicated.

Abstract: A method for the layered production of a green body (10) from powdery material, including insert elements which are placed at defined positions in the powdery material, in which the green body (10) is segmented in a building direction (16) into N, N?2 consecutive, cylindrical cross-sectional areas (11, 12, 13, 14, 15) made up of a two-dimensional cross-sectional surface and a layer thickness. Setting areas for the insert elements are defined in the cross-sectional areas of the green body (10) which include the defined positions for the insert elements, and loose powder particles surrounding the setting elements are at least partially bonded to each other before the insert elements are placed into the powdery material.

Abstract: A method for the layered production of a component (10) from powdery material including loose powder particles, based on three-dimensional data of the component (10), including the method steps: the component (10) is segmented in a building direction (16) into N, N?2 consecutive, cylindrical cross-sectional areas (11, 12, 13, 14, 15) made up of a two-dimensional cross-sectional surface and a layer thickness; N powder layers of the powdery material are applied to a building plane perpendicular to the building direction (16); the loose powder particles in the cross-sectional areas (11, 12, 13, 14, 15) of the component (10) are at least partially bonded to each other and to the underlying cross-sectional area and; loose powder particles arranged within one cross-sectional area or within multiple consecutive cross-sectional areas in the building direction (16) are at least partially removed from the component (10) during the layered production of the component (10).

Abstract: A conjugate comprising a protein or a peptide, a linker and an active agent, wherein the linker comprises the moiety of formula (III): (III) wherein two of A1, A2 and A3 are N and the other of A1, A2 and A3 is CH; X is selected from N, O and S, and Pep indicates where the moiety is linked to the protein or peptide, either directly or indirectly.

Abstract: A method for the layered production of a green body from powdery or paste-like material, including cutting elements based on three-dimensional data of the green body, the green body being segmented in a building direction into N (N?2) consecutive cylindrical cross-sectional areas made up of a two-dimensional cross-sectional surface perpendicular to the building direction and a layer thickness in parallel to the building direction, including the method steps: the cross-sectional areas of the green body are each divided into material areas, and setting areas, in which the cutting elements are situated; the material areas in the building direction are applied to a building plane situated perpendicularly to the building direction, until at least one cavity formed by one setting area or by multiple consecutive setting areas in the building direction, has the necessary insert height for placing the cutting elements; and at least one cutting element is placed into the cavities having the necessary insert height for

Abstract: A thread-forming screw has a shank which, in a front region of the shank, has a tip for insertion into a bore in a substrate, and in a rear region of the shank, has a drive for transmitting a torque to the shank. The shank has a spiral-shaped groove and a thread spiral which is inserted into the spiral-shaped groove. The spiral-shaped groove has a front flank and a rear flank disposed opposite the front flank. The front flank, at least regionally, has a different part flank angle than the rear flank.

Abstract: A method for the layered production of a component (10) from powdery material including loose powder particles, based on three-dimensional data of the component (10), including the method steps: the component (10) is segmented in a building direction (16) into N, N?2 consecutive, cylindrical cross-sectional areas (11, 12, 13, 14, 15) made up of a two-dimensional cross-sectional surface and a layer thickness; N powder layers of the powdery material are applied to a building plane perpendicular to the building direction (16); the loose powder particles in the cross-sectional areas (11, 12, 13, 14, 15) of the component (10) are at least partially bonded to each other and to the underlying cross-sectional area and; loose powder particles arranged within one cross-sectional area or within multiple consecutive cross-sectional areas in the building direction (16) are at least partially removed from the component (10) during the layered production of the component (10).

Abstract: A method for the layered production of a green body (10) from powdery material, including insert elements which are placed at defined positions in the powdery material, in which the green body (10) is segmented in a building direction (16) into N, N?2 consecutive, cylindrical cross-sectional areas (11, 12, 13, 14, 15) made up of a two-dimensional cross-sectional surface and a layer thickness. Setting areas for the insert elements are defined in the cross-sectional areas of the green body (10) which include the defined positions for the insert elements, and loose powder particles surrounding the setting elements are at least partially bonded to each other before the insert elements are placed into the powdery material.

Abstract: A method for the layered production of a green body from powdery or paste-like material, including cutting elements based on three-dimensional data of the green body, the green body being segmented in a building direction into N (N?2) consecutive cylindrical cross-sectional areas made up of a two-dimensional cross-sectional surface perpendicular to the building direction and a layer thickness in parallel to the building direction, including the method steps: the cross-sectional areas of the green body are each divided into material areas, and setting areas, in which the cutting elements are situated; the material areas in the building direction are applied to a building plane situated perpendicularly to the building direction, until at least one cavity formed by one setting area or by multiple consecutive setting areas in the building direction, has the necessary insert height for placing the cutting elements; and at least one cutting element is placed into the cavities having the necessary insert height for

Abstract: A thread-forming screw has a shank which, in a front region of the shank, has a tip for insertion into a bore in a substrate, and in a rear region of the shank, has a drive for transmitting a torque to the shank. The shank has a spiral-shaped groove and a thread spiral which is inserted into the spiral-shaped groove. The spiral-shaped groove has a front flank and a rear flank disposed opposite the front flank. The front flank, at least regionally, has a different part flank angle than the rear flank.

Abstract: The present invention is an improvement in the design of a perforating gun to perforate the casing and rock formations in oil and gas wells. Perforating guns are cylindrical vessels with explosive charges at specified intervals designed to shoot perpendicularly outwardly through the vessel, perforating the casing and into the rock formation. As most wells are generally straight and most formations are relatively flat, the perforations are horizontal in the same direction as the bedding plane of the rock formations. The present invention is to angle the explosive charges so as to cause the perforation to shoot at an angle to horizontal and across the bedding planes of the rock formations. The angled perforations can result in improved completions in stratified reservoirs and fractured reservoirs by contacting all the stratified layers for production and contacting more of the fractures for production.

Abstract: A process information and maintenance system for monitoring, visualizing, triaging and maintaining all control loops of a distributed control system gives the users the number of control loops in the plant, the number of loops that are routinely in manual mode, which loops are frequently in alarm, which loops need tuning, etc.