Patents by Inventor Robert STADELMAN

Robert STADELMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scalable method for recombinant AAV production
    Patent number: 12612644
    Abstract: Provided herein are improved methods for producing recombinant Adeno-Associated Virus (rAAV) particles. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor and increased amount of a sodium salt.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: April 28, 2026
    Assignee: REGENXBIO INC.
    Inventors: Michael Gillmeister, Miguel Valle, Robert Stadelman, Franz Gerner, Matthieu Guibert, Bhargavi Kondragunta
  • METHOD OF PRODUCING A RECOMBINANT VIRUS PARTICLE
    Publication number: 20240167054
    Abstract: Provided herein are improved methods for producing recombinant virus particles. In some embodiments, a method for producing recombinant virus particles described herein comprises providing a suspension cell culture comprising a population of cells capable of producing the virus particle, transferring a first volume of poly nucleotide:transfection reagent complexes to the suspension culture to transfect the cells, and transferring a second volume of polynucleotide:transfection reagent complexes to the suspension culture, wherein the transferring of the first and second volume of polynucleotide:transfection reagent complexes are performed simultaneously or consecutively in any order. In some embodiments, the recombinant virus particles are recombinant AAV (rAAV) particles.
    Type: Application
    Filed: December 16, 2021
    Publication date: May 23, 2024
    Inventors: Robert STADELMAN, Donald STARTT
  • SCALABLE METHOD FOR RECOMBINANT AAV PRODUCTION
    Publication number: 20210163991
    Abstract: Provided herein are improved methods for producing recombinant Adeno-Associated Virus (rAAV) particles. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor and increased amount of a sodium salt.
    Type: Application
    Filed: August 9, 2019
    Publication date: June 3, 2021
    Inventors: Michael GILLMEISTER, Miguel VALLE, Robert STADELMAN, Franz GERNER, Matthieu GUIBERT, Bhargavi KONDRAGUNTA