Abstract: The disclosure provides artificial nucleic acid introns configured for selective splicing in cells with aberrant RNA splicing activity, e.g., neoplastic cells. The artificial intron can comprise an upstream flanking exon, an upstream intron, an alternatively spliced “cassette” exon, a downstream intron, and a downstream flanking exon. Also provided are constructs integrating the artificial introns with exons in a configuration that, when the artificial intron is spliced out by the aberrant RNA splicing factors, encode a functional protein. Also disclosed are methods that employ the disclosed platform of selective expression, including, targeted gene therapy methods (e.g., in cancers), diagnostics and imaging, and drug screening.

Abstract: A remotely deployed, inflatable device designed to reduce or eliminate falls in senior living and assisted care facilities. Upon detecting undesired movement, nurses may deploy one or more inflatable cylinders, thereby inflating the device under one or both sides of the mattress, creating a barrier that prevents the resident from exiting the bed until on-site assistance arrives. It is envisioned that initially the operation of the device will rely on the remote monitoring of residents by one or more operators via live camera feeds. In more advanced versions it is envisioned that software and artificial intelligence will be able to use one or more camera feeds and will be able to supplement or even replace the need for a person to monitor any camera feeds.

Abstract: Tip-off is a process of bringing a transport vehicle to a target weight by using only part of a bucket of a loader. By observing sensor data, tip-off may be automatically determined. Once determined, a visual indication may be made to an operator, allowing the operator to both confirm that tip-off mode is active and to show what tip-off mode is selected, truck tip-off or pile tip-off. Among other benefits, automatic tip-off allows an operator to maintain contact with the loader controls when entering tip-off mode of operation.

Abstract: Tip-off is a process of bringing a transport vehicle to a target weight by using only part of a bucket of a loader. By observing sensor data, tip-off may be automatically determined. Once determined, a visual indication may be made to an operator, allowing the operator to both confirm that tip-off mode is active and to show what tip-off mode is selected, truck tip-off or pile tip-off. Among other benefits, automatic tip-off allows an operator to maintain contact with the loader controls when entering tip-off mode of operation.

Abstract: This invention is for a docking aid to help dock a boat to a docking post, or to pull a boat closer to the shore. It comprises of a shaft and a tensile member. The tensile member may pass through the shaft and form one or more loops at the ends of the shaft. One loop may be used to dock to a docking pole, while a second loop may be used as a handle to pull, or to loop around another docking element. At least one loop may have a utility implement with an attached tool. This tool may be used to grab a docking post from a boat, to grab an inbound boat from a dock, to pull closer to a second boat, or to grab objects out of the water that may have fallen overboard. The docking aid may also be floatable.

Abstract: This invention is for a docking aid to help dock a boat to a docking post, or to pull a boat closer to the shore. It comprises of a shaft and a tensile member. The tensile member may pass through the shaft and form one or more loops at the ends of the shaft. One loop may be used to dock to a docking pole, while a second loop may be used as a handle to pull, or to loop around another docking element. At least one loop may have a utility implement with an attached tool. This tool may be used to grab a docking post from a boat, to grab an inbound boat from a dock, to pull closer to a second boat, or to grab objects out of the water that may have fallen overboard. The docking aid may also be floatable.

Abstract: A portable vault assembly is claimed that can provide secure on-site storage, yet may be disassembled easily for removal to a new location when desired. The portable vault includes sections that are independently portable but which feature a combined weight that makes it impossible for the secured container, or vault, to be carried. Further embodiments rely upon features of the site where the vault is assembled to create a secure space, and independent portable vaults may be co-joined to form integrated but separate storage compartments, or one large central storage bin, as desired. Anchoring options, and further theft deterrence features are also disclosed including integration to the work site environment.

Abstract: A compact disc player and a method and an article of manufacture for controlling ejection of a compact disc are provided. The compact disc player includes a temperature sensor configured to generate a signal indicative of a temperature of the compact disc player utilizing a temperature sensor. The compact disc player further includes a controller operably communicating with the temperature sensor. The controller is configured to determine an ejection time interval value based on the signal. The controller is further configured to energize a motor coupled to a drive mechanism for a time internal corresponding to the ejection time interval value to induce the drive mechanism to move a compact disc to a predetermined position outwardly from a housing.

Abstract: In one aspect, the invention provides an architecture and query and processing methodology, advantageously implemented in software, for an information technology platform using Intelligent Molecular Objects or objects of a more general character. In another aspect, it provides intelligent molecular object data or other data for heterogeneous data environments with high data density and dynamic application needs. In yet another, it provides an Object State Engine for intelligent molecular object data technology. In still another, it provides an Object Translation Engine for intelligent molecular object data in heterogeneous data environments with dynamic application needs. In yet another aspect, it provides a handling device including an Intelligent Object Handler for intelligent molecular object data in heterogeneous data environments with high data density and dynamic application needs.

Abstract: A system for locating a vehicle among a large number of vehicles. A lock box unit is mounted on a vehicle and includes a key box for storing a vehicle key and a locator unit. The locator unit receives a polling signal from a central base station which includes an address for the particular locator unit to be located. The locator unit decodes the polling signal to determine whether the signal is includes its unique address. If the polling signal is meant for the locator unit then the locator unit transmits a spread spectrum to at least three receiving antennas. The location of the locator unit and therefore the vehicle is determined based upon time arrival data generated by the receiving antennas. The lock box unit may also include an identification device which records who accesses the key box to retrieve the vehicle key. This information is stored in a memory device.

Abstract: Saw blades and methods of manufacturing saw blades.

Abstract: A process for recovery of platinum and palladium from an impure substantially gold-free precious and base metal-bearing acidic chloride or mixed chloride/sulphate solution comprises the steps of: contacting the acidic solution having a pH less than about 1.5 with an organic solution comprising an 8-hydroxy quinoline solvent extraction reagent, a phase modifier and an aromatic diluent to extract simultaneously platinum and palladium into the organic solution; scrubbing the loaded organic solution to remove co-extracted impurities and acid; stripping the loaded organic with a buffer solution operating in the pH range 2-5 at 20.degree.-50.degree. C. to selectively recover the platinum; stripping the platinum-free loaded organic with 3-8 M hydrochloric acid to recover the palladium; and regenerating the organic solution by washing with water.