Abstract: Provided herein are enhanced imaging techniques which allow for the use of multiple optical sensors, each of which corresponds to only a portion of an array, including utilizing individual sensors for each individual well of a multi-well plate. The provided systems and methods may reduce the amount of time to perform optical analysis of an array, reduce the amount of moving parts or mechanical devices required to perform optical analysis and/or reduce the amount of space between the sensors and the array being analyzed resulting in more compact, efficient optical analyzers.

Abstract: An embodiment provides a method, including: operating a motor to position sample fluid within a fluid channel of a cuvette; transmitting light through an optical chamber of the cuvette; measuring a value of received light that has been transmitted through the optical chamber; comparing the measured value of light to one or more thresholds; determining a position of the sample fluid within the fluid channel based on a comparison from the comparing step; and generating a response based upon the position of the sample fluid with the fluid channel. Other aspects are described and claimed.

Abstract: Provided herein are methods for characterizing pathogens based on data profiles generated by an analyzer. The provided methods allow for rapid identification and characterization of emergent pathogens or mutations by allowing for facile updates to the established pathogen data used by learning algorithms, while not altering the independent learning algorithms themselves.

Abstract: Provided herein are enhanced imaging techniques which allow for the use of multiple optical sensors, each of which corresponds to only a portion of an array, including utilizing individual sensors for each individual well of a multi-well plate. The provided systems and methods may reduce the amount of time to perform optical analysis of an array, reduce the amount of moving parts or mechanical devices required to perform optical analysis and/or reduce the amount of space between the sensors and the array being analyzed resulting in more compact, efficient optical analyzers.

Abstract: An embodiment provides a cuvette, including: a body having a fluid channel therein; and an outer surface having encoded information disposed thereon and readable by a reader of a sample instrument. Other aspects are described and claimed.

Abstract: The invention provides microarray systems and methods for pathogen identification and characterization. Aspects of the invention implement supervised learning for microarray data analysis to enhance the accuracy and scope of genomic and diagnostic information obtained. Embodiments of the invention, for example, utilize structured logical combinations of the output of independent supervised learning algorithms, such as artificial neural network (ANN) algorithms, to provide an efficient and rapid pathway to clinically and epidemiologically relevant diagnostic information.

Abstract: An embodiment provides a method, including: operating a motor to position sample fluid within a fluid channel of a cuvette; transmitting light through an optical chamber of the cuvette; measuring a value of received light that has been transmitted through the optical chamber; comparing the measured value of light to one or more thresholds; determining a position of the sample fluid within the fluid channel based on a comparison from the comparing step; and generating a response based upon the position of the sample fluid with the fluid channel. Other aspects are described and claimed.

Abstract: An embodiment provides a method, including: operating a motor to position sample fluid within a fluid channel of a cuvette; transmitting light through an optical chamber of the cuvette; measuring a value of received light that has been transmitted through the optical chamber; comparing the measured value of light to one or more thresholds; determining a position of the sample fluid within the fluid channel based on a comparison from the comparing step; and generating a response based upon the position of the sample fluid with the fluid channel. Other aspects are described and claimed.

Abstract: Systems and methods are disclosed herein for measuring the electromechanical delay of the heart of a patient. An electrocardiogram (EKG) signal may be used to detect heart electrical activity. Photoplethysmograph (PPG) signals may be used to detect heart mechanical activity. The electromechanical delay may be calculated based at least in part on the timing of an EKG signal and at least two PPG signals.

Abstract: An embodiment provides a cuvette, including: a body having a fluid channel therein; and an outer surface having encoded information disposed thereon and readable by a reader of a sample instrument. Other aspects are described and claimed.

Abstract: An embodiment provides a method, including: operating a motor to position sample fluid within a fluid channel of a cuvette; transmitting light through an optical chamber of the cuvette; measuring a value of received light that has been transmitted through the optical chamber; comparing the measured value of light to one or more thresholds; determining a position of the sample fluid within the fluid channel based on a comparison from the comparing step; and generating a response based upon the position of the sample fluid with the fluid channel. Other aspects are described and claimed.

Abstract: An embodiment provides a cuvette apparatus including: a lid and a body, the body including a fluid channel disposed therein; and the lid including at least one opening aligned with a portion of the fluid channel, thereby providing access to the fluid channel in the body. Other aspects are described and claimed.

Abstract: An embodiment provides a cuvette apparatus including: a lid and a body, the body including a fluid channel disposed therein; and the lid including at least one opening aligned with a portion of the fluid channel, thereby providing access to the fluid channel in the body. Other aspects are described and claimed.

Abstract: The present disclosure relates to systems and methods for analyzing and normalizing signals, such as PPG signals, for use in patent monitoring. The PPG signal may be detected using a continuous non-invasive blood pressure monitoring system and the normalized signals may be used to determine whether a recalibration of the system should be performed.

Abstract: The present disclosure relates to systems and methods for analyzing and normalizing signals, such as PPG signals, for use in patent monitoring. The PPG signal may be detected using a continuous non-invasive blood pressure monitoring system and the normalized signals may be used to determine whether a recalibration of the system should be performed.

Abstract: A method and system for automatically gating an imaging device is disclosed. Physiological process information of a patient may be derived from a plethysmographic signal, for example, by analyzing the plethysmographic signal transformed by a continuous wavelet transform. Other techniques for deriving physiological process information of a patient include, for example, analyzing a scalogram derived from the continuous wavelet transform. The physiological process information may be used to automatically gate imaging data acquired from an imaging device in order to synchronize the imaging data with the physiological process information.

Abstract: Systems and methods are disclosed herein for calibrating the calculation of physiological parameters. Two or more calibration techniques may be used to determine a relationship between physiological measurements and a desired physiological parameter, such as a relationship between differential pulse transit time (DPTT) and blood pressure. Different calibration techniques may be used in a serial fashion, one after the other, or in a parallel fashion, with different weights accorded to each calibration technique. When physiological or other changes occur, the calibration data may be stored for later use and new calibration data may be generated.

Abstract: Systems and methods are disclosed herein for measuring the electromechanical delay of the heart of a patient. An electrocardiogram (EKG) signal may be used to detect heart electrical activity. Photoplethysmograph (PPG) signals may be used to detect heart mechanical activity. The electromechanical delay may be calculated based at least in part on the timing of an EKG signal and at least two PPG signals.

Abstract: A method and system for automatically gating an imaging device is disclosed. Physiological process information of a patient may be derived from a plethysmographic signal, for example, by analyzing the plethysmographic signal transformed by a continuous wavelet transform. Other techniques for deriving physiological process information of a patient include, for example, analyzing a scalogram derived from the continuous wavelet transform. The physiological process information may be used to automatically gate imaging data acquired from an imaging device in order to synchronize the imaging data with the physiological process information.