Patents by Inventor Robert Striker

Robert Striker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREDICTING HCV SUSCEPTIBILITY TO ANTIVIRAL AGENTS
    Publication number: 20120077738
    Abstract: Methods for determining the susceptibility of a hepatitis C virus (HCV) in a patient to anti-viral agents, particularly cyclophilin inhibitors such as cyclosporine A, are disclosed. The methods include determining the amino acid sequence within a region of the HCV NS5A protein and comparing the viral amino acid sequence to that of a reference strain, wherein the existence of at least one variant/mutation in the viral genome is indicative that the virus is more or less susceptible to anti-viral agents. Also disclosed are isolated polynucleotide molecules, replicons, and kits that can be used to assay the susceptibility of hepatitis HCV in a patient to anti-viral agents.
    Type: Application
    Filed: September 9, 2011
    Publication date: March 29, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Robert Striker, Israr Ansari
  • 2?,3?-dideoxynucleoside analogues for the treatment or prevention of infections
    Patent number: 7772208
    Abstract: A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a ?-L- or ?-D-2?,3?-dideoxynucleoside or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable diluent or excipient.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: August 10, 2010
    Assignees: Pharmasset, Inc., Leland Stanford Junior University, Emory University
    Inventors: Raymond Schinazi, Robert Striker, Junxing Shi
  • 2', 3'-DIDEOXYNUCLEOSIDE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE INFECTIONS
    Publication number: 20080280846
    Abstract: A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a ?-L- or ?-D-2?,3?-dideoxynucleoside or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable diluent or excipient.
    Type: Application
    Filed: January 8, 2008
    Publication date: November 13, 2008
    Applicants: Pharmasset, Inc., Emory University, Leland Stanford Junior University
    Inventors: Raymond F. Schinazi, Junxing Shi, Robert Striker
  • ANTIVIRAL AGENTS AND METHODS OF USE
    Publication number: 20050119284
    Abstract: The present invention provides therapeutic methods of inhibiting RNA viruses based on the newly-discovered anti-viral activity of cis or trans-6-(2-acetylvinylthio)purine (cis-AVTP) or (trans-AVTP). RNA viruses inhibited by the methods include flaviviruses, namely hepatitis C virus (HCV) and bovine diarrhea virus (BVDV).
    Type: Application
    Filed: September 30, 2004
    Publication date: June 2, 2005
    Inventors: Robert Striker, Adnan Elfarra, Sjofn Gunnarsdottir, Spencer Hoover
  • 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
    Publication number: 20040067877
    Abstract: A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a &bgr;-L- or &bgr;-D-2′,3′-dideoxynucleoside or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable diluent or excipient.
    Type: Application
    Filed: August 1, 2003
    Publication date: April 8, 2004
    Inventors: Raymond F. Schinazi, Robert Striker, Junxing Shi