Patents by Inventor Robert Strongin
Robert Strongin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9952231Abstract: Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.Type: GrantFiled: March 14, 2014Date of Patent: April 24, 2018Assignee: Portland State UniversityInventors: Robert Strongin, Martha Sibrian-Vazquez, Jialu Wang, Lei Wang, Jorge O. Escobedo-Cordova
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Patent number: 9709572Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: GrantFiled: November 24, 2015Date of Patent: July 18, 2017Assignee: Portland State UniversityInventors: Robert Strongin, Xiaofeng Yang
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Publication number: 20160077103Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: ApplicationFiled: November 24, 2015Publication date: March 17, 2016Applicant: Portland State UniversityInventors: Robert Strongin, Xiaofeng Yang
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Publication number: 20160047830Abstract: Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.Type: ApplicationFiled: March 14, 2014Publication date: February 18, 2016Inventors: Robert STRONGIN, Martha SIBRIAN-VAZQUEZ, Jialu WANG, Lei WANG, Jorge O. ESCOBEDO-CORDOVA
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Patent number: 9229007Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: GrantFiled: August 2, 2012Date of Patent: January 5, 2016Assignee: Portland State UniversityInventors: Robert Strongin, Xiaofeng Yang
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Patent number: 8933129Abstract: The present teachings provide compounds of Formulae I and II: and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R1, R1?, R2, R2?, R3, R3?, and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.Type: GrantFiled: April 15, 2010Date of Patent: January 13, 2015Assignee: State of Oregon by and through the State Board of Higher Education on behalf of Portland State UniversityInventors: Jonathan Abramson, Robert Strongin
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Publication number: 20140371193Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.Type: ApplicationFiled: September 4, 2014Publication date: December 18, 2014Applicants: LOUISIANA STATE UNIVERSITY, WOMEN & INFANTS' HOSPITALInventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
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Publication number: 20140206095Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: ApplicationFiled: August 2, 2012Publication date: July 24, 2014Applicant: State of Oregon Acting by and through the State Board of Higher Education on behalf of Portland stInventors: Robert Strongin, Xiaofeng Yang
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Publication number: 20130023511Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.Type: ApplicationFiled: July 23, 2012Publication date: January 24, 2013Applicants: LOUISIANA STATE UNIVERSITY, WOMEN & INFANTS' HOSPITALInventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
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Patent number: 8252780Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.Type: GrantFiled: November 30, 2007Date of Patent: August 28, 2012Assignees: Women & Infants' Hospital, Louisiana State UniversityInventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
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Publication number: 20100273763Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.Type: ApplicationFiled: November 30, 2007Publication date: October 28, 2010Applicants: Women & Infants Hospital, Louisiana State UniversityInventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
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Patent number: RE48928Abstract: Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.Type: GrantFiled: April 24, 2020Date of Patent: February 15, 2022Assignee: Portland State UniversityInventors: Robert Strongin, Martha Sibrian-Vazquez, Jialu Wang, Lei Wang, Jorge O. Escobedo-Cordova