Abstract: A breathing assistance apparatus and related systems for data capture, processing, storage and rendering. The data may related to a personal health enquiry presented to a patient of a breathing assistance apparatus on a display screen of the apparatus. The responses to a set of queries in the enquiry may be captured as answer data. The answer data may then be transmitted and/or processed relative to baseline data for access and rendering as one or more data reports and/or time-series charts.

Abstract: A respiratory mask or other sealing interface can be used in combination with a nasal cannula or other unsealing interface in providing respiratory therapies for the treatment of COPD or OSA. The mask can act as a pressure vessel over the top of a nasal cannula, with the intention of increasing expiratory pressure whilst allowing the nasal cannula to provide a user with breathing gases of a high humidity and temperature. The ability to selectively apply increased expiratory pressure may be effective in reducing a user's breathing rate and thus beneficial in the treatment of respiratory distress.

Abstract: The present disclosure provides to graphical user interfaces for controlling a flow therapy apparatus. The graphical user interface can provide a display of flow therapy treatment information and indicators of a patient's health. The graphical user interface can be configured to display the information associated with the patient on one or more user interface screens.

Abstract: A method of operating a modular exoskeleton system, the method comprising: monitoring for one or more actuator units being operably coupled to or removed from the modular exoskeleton system, the modular exoskeleton system comprising at least a first actuator unit configured to be operably coupled and removed from the modular exoskeleton system; determining that the first actuator unit has been operably coupled to the modular exoskeleton system; determining the first actuator unit has been associated with a first body portion of the user; determining a first new operating configuration based at least in part on the determination that the first actuator unit has been operably coupled to the modular exoskeleton system and the determination that the first actuator unit has been associated with the first body portion of the user; and setting the first new operating configuration for the modular exoskeleton system.

Abstract: Encoding and decoding systems are described for the provision of high quality digital representations of audio signals with particular attention to the correct perceptual rendering of fast transients at modest sample rates. This is achieved by optimising downsampling and upsampling filters to minimise the length of the impulse response while adequately attenuating alias products that have been found perceptually harmful.

Abstract: A flow therapy apparatus can provide a hypoxic flow of gases to a user, for altitude training, athletic performance training, and other indications. The system can include an apparatus that can include a gas conduit, an ambient air inlet, and a hypoxic gas source inlet configured to connect to a hypoxic gas source and configured to create a hypoxic gas composition upon mixing of ambient air and the hypoxic gas. The system can also include a user interface, and a gas flow generation element configured to deliver the hypoxic gas composition to nares of the user at a predetermined flow rate of at least about 10 liters/minute. Methods are also disclosed.

Abstract: Encoding and decoding systems are described for the provision of high quality digital representations of audio signals with particular attention to the correct perceptual rendering of fast transients at modest sample rates. This is achieved by optimising downsampling and upsampling filters to minimise the length of the impulse response while adequately attenuating alias products that have been found perceptually harmful.

Abstract: A water heater can include a heat source and a heat exchanger that transfers heat to the water. A header attached to the heat exchanger provides an inlet and an outlet for water to flow into and out of the heat exchanger. The header can also include an anode assembly that releasably attaches to the header. The anode assembly can be located at a bottom of the header so that an anode in the anode assembly remains in contact with the water when water is flowing through the heat exchanger.

Abstract: A high efficiency configuration for a solar cell module comprises solar cells conductively bonded to each other in a shingled manner to form super cells, which may be arranged to efficiently use the area of the solar module, reduce series resistance, and increase module efficiency.

Abstract: The present invention relates to an oncolytic virus encoding a CTLA-4 inhibitor, such as an anti-CTLA-4 antibody, or an antigen binding fragment thereof.

Abstract: A respiratory mask or other sealing interface can be used in combination with a nasal cannula or other unsealing interface in providing respiratory therapies for the treatment of COPD or OSA. The mask can act as a pressure vessel over the top of a nasal cannula, with the intention of increasing expiratory pressure whilst allowing the nasal cannula to provide a user with breathing gases of a high humidity and temperature. The ability to selectively apply increased expiratory pressure may be effective in reducing a user's breathing rate and thus beneficial in the treatment of respiratory distress.

Abstract: The present invention relates to an oncolytic virus which is, or is derived from, a clinical isolate which has been selected by comparing the abilities of a panel of three or more clinical isolates of the same viral species to kill tumor cells of two or more tumor cell lines in vitro and selecting a clinical isolate which is capable of killing cells of two or more tumor cell lines more rapidly and/or at a lower dose in vitro than one or more of the other clinical isolates in the panel.

Abstract: The present invention relates to an oncolytic virus encoding a CTLA-4 inhibitor, such as an anti-CTLA-4 antibody, or an antigen binding fragment thereof.

Abstract: The present invention relates to oncolytic virus comprising: (i) a GM-CSF-encoding gene; and (ii) an immune co-stimulatory pathway activating molecule or an immune co-stimulatory pathway activating molecule-encoding gene.

Abstract: A system for compactly storing and easily transporting one or more two-wheeled vehicles, comprising a plurality of slender trays, wherein each tray comprises a tray base, one or more slotted wheel housing(s), a wheel securement subassembly; one or more cross-member(s); a plurality of casters and/or resting pads; wherein the tray bases are attached to the cross-member(s) at an orthogonal angle; wherein the casters and/or resting pads are each attached to the underside of the cross-member(s). Trays may be secured to the cross-members so that the front of each bicycle is oriented in an alternating fashion from one tray to the next. The longitudinal fore-aft position of each tray may also be in a staggered arrangement. Finally, vertical riser blocks placed between a cross-member and a tray may be further employed.

Abstract: Methods and devices are described for reducing the audible effect of pre-responses in an audio signal. The pre-responses are effectively delayed by employing a digital non-minimum-phase filter, which includes a zero lying outside the unit circle in its z-transform response. This zero is not paired with another zero at a reciprocal position inside the unit circle, as this would linearise the phase modification. The filtering can introduce a greater group delay at the pre-response frequency than at a low frequency, such as 500 Hz or even 0 Hz. The technique can be used to reduce pre-responses in an existing audio signal and also to pre-empt pre-responses that would be introduced to the audio signal by subsequent processing.

Abstract: The invention provides pyridinylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

Abstract: A high efficiency configuration for a solar cell module comprises solar cells conductively bonded to each other in a shingled manner to form super cells, which may be arranged to efficiently use the area of the solar module, reduce series resistance, and increase module efficiency.

Abstract: A high efficiency configuration for a solar cell module comprises solar cells conductively bonded to each other in a shingled manner to form super cells, which may be arranged to efficiently use the area of the solar module, reduce series resistance, and increase module efficiency.