Abstract: A method comprises generating, via a pulse generator, a first pressure pulse in a fluid in a pipe and detecting, via a transducer, a first reflected pressure pulse based on the first pressure pulse, wherein the first pressure pulse is reflected by a pipe feature to generate the first reflected pressure pulse. The method comprises generating, with the pulse generator, a second pressure pulse at a later time relative to generating the first pressure pulse, wherein timing of generating of the second pressure pulse is such that the second pressure pulse is superposed with the first reflected pressure pulse such that an amplitude of the second pressure pulse is greater than an amplitude of the first pressure pulse. The method comprises detecting, via the transducer, a second reflected pressure pulse based on the second pressure pulse, and detecting a pipe feature based on the second reflected pressure pulse.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: In the described embodiments, a connection data exchange (“CDX”) service serves as an exchange point for connection data for establishing peer-to-peer (“P2P”) connections between devices. During operation, the CDX service can receive a connection data structure (a “ticket”) that was created by a matchmaker or an invitation service in response to requests from devices attempting to establish P2P connections. Each ticket can identify a corresponding device and can include encrypted NAT hole-punch data associated with the corresponding device. The CDX service can authenticate each ticket and decrypt the NAT hole punch data from the ticket using a corresponding key. The CDX service can then use corresponding NAT hole punch data to send connection data to each of the devices that reside behind NAT devices.

Abstract: A method of producing fabrics which show a silk-like visual effect and soft hand-feel and retains such effects after being stretched and returned to its original size. This method combines a specific fabric structure and the treatment with a silicon oil in the finishing process. The particular fabric structure has nylon yarns which is close looped and elastic spandex yarns which is open looped.

Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: In the described embodiments, a connection data exchange (“CDX”) service serves as an exchange point for connection data for establishing peer-to-peer (“P2P”) connections between devices. During operation, the CDX service can receive a connection data structure (a “ticket”) that was created by a matchmaker or an invitation service in response to requests from devices attempting to establish P2P connections. Each ticket can identify a corresponding device and can include encrypted NAT hole-punch data associated with the corresponding device. The CDX service can authenticate each ticket and decrypt the NAT hole punch data from the ticket using a corresponding key. The CDX service can then use corresponding NAT hole punch data to send connection data to each of the devices that reside behind NAT devices.

Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.

Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: An apparatus, method, and machine-readable medium are described for securely and efficiently exchanging connection data for a peer-to-peer (“P2P”) session on a network comprising. For example, in one embodiment, a connection data exchange (“CDX”) service can perform the function of a central exchange point for connection data. In one embodiment, the CDX service can perform the operations of receiving a connection data structure, sometimes referred to herein as a “ticket,” created by a matchmaker or an invitation service in response to requests from a group of mobile computing devices attempting to establish peer-to-peer (“P2P”) connections. The ticket can identify each of the group of mobile computing devices and can include encrypted NAT hole punch data associated with each of the mobile computing devices.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.