Patents by Inventor Robert Sutherland
Robert Sutherland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230191131Abstract: A system may include a therapy device configured to deliver a therapy to a patient, a feature detector, and a feature selection controller. The therapy device may include sensing circuitry configured to sense a biological signal from the patient, and a closed-loop controller operably connected to the therapy device and the sensing circuitry. The controller may be configured to implement a feedback control algorithm to control the delivered therapy based on the sensed signal by controlling at least one therapy parameter. The feature detector may be configured to detect a plurality of available features of the biological signal. The feature selection controller may be configured to implement a feature selection algorithm to determine closed-loop sensed feature(s) from the plurality of available features. The feedback control algorithm may be configured to use the at least one closed-loop sensed feature to control the therapy parameter(s).Type: ApplicationFiled: December 20, 2022Publication date: June 22, 2023Inventors: Adarsh Jayakumar, Robert Sutherland
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Patent number: 8535712Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.Type: GrantFiled: September 10, 2012Date of Patent: September 17, 2013Assignees: Varian Medical Systems, Inc., Arizona Board of Regents on Behalf of the University of ArizonaInventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
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Publication number: 20130224730Abstract: A method of solid phase selection of peptide ligands for target proteins is presented. 15-20mers or greater are addressed in a microarray, and the target protein and optional competitor bound thereto and binding compared. A specific signal for the target protein indicates that a peptide has strong affinity for the target. Ligands can be coupled to solid supports and used for affinity purification of the target proteins as well as detection and modulation of target proteins. Specific peptide ligands for immuno-purifying norovirus.Type: ApplicationFiled: November 16, 2010Publication date: August 29, 2013Applicant: ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Stephen A. Johnston, Christopher Diehnelt, Paul Belcher, Charles J. Arntzen, Robert Sutherland
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Publication number: 20130202577Abstract: The invention relates to the finding that T cell protein tyrosine phosphatase (TCPTP) has a tumour suppressor function. In one particular application, the invention provides a method of diagnosis and/or prognosis of cancer in a subject involving the assessment, in a suitable body sample, of any lack or reduction of TCPTP protein and/or Ptpn2 gene expression. The invention also provides a method of treating or preventing cancer in a subject involving administering to a subject an agent for modulating the activity of TCPTP.Type: ApplicationFiled: February 3, 2011Publication date: August 8, 2013Applicant: MONASH UNIVERSITYInventors: Tony Tiganis, Benjamin James Shields, Catriona Ann McLean, Robert Sutherland
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Publication number: 20130053618Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.Type: ApplicationFiled: September 10, 2012Publication date: February 28, 2013Applicant: Varian Medical Systems, Inc.Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
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Publication number: 20110217236Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing, radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.Type: ApplicationFiled: October 11, 2010Publication date: September 8, 2011Applicant: Varian Medical Systems, Inc.Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
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Patent number: 7700316Abstract: The invention is a CD109 nucleic acid molecule and its corresponding polypeptide. The invention also includes biologically functional equivalent nucleic acid molecules and polypeptides. The invention also relates to methods of using these nucleic acid sequences and polypeptides in medical diagnosis and treatment and in drug screening.Type: GrantFiled: March 7, 2002Date of Patent: April 20, 2010Inventors: Andre Schuh, D. Robert Sutherland
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Patent number: 7660384Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.Type: GrantFiled: May 23, 2008Date of Patent: February 9, 2010Assignee: Varian Medical Systems, Inc.Inventors: Larry Partain, Stavros Prionas, Edward Seppi, Robert Sutherland, David Humber, Hassan Mostafavi, Felix Fernando, John Boone
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Publication number: 20090233286Abstract: Disclosed herein are methods of diagnosing pancreatic cancer in a subject. Also provided are methods of monitoring the efficacy of a therapeutic treatment of pancreatic cancer as well as methods of determining the likelihood that a subject having pancreatic cancer will survive, and methods of determining the suitability of a subject having pancreatic cancer for surgical resection therapy.Type: ApplicationFiled: October 22, 2008Publication date: September 17, 2009Inventors: Davendra Segara, Andrew Biankin, Robert Sutherland, Susan Henshall
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Publication number: 20080226018Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.Type: ApplicationFiled: May 23, 2008Publication date: September 18, 2008Applicant: Varian Medical Systems Technologies, Inc.Inventors: Larry D. Partain, Stavros Prionas, Edward Seppi, Robert Sutherland, David Humber, Hassan Mostafavi, Felix Fernando, John Boone
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Patent number: 7394889Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.Type: GrantFiled: May 18, 2006Date of Patent: July 1, 2008Assignee: Varian Medical Systems Technologies, Inc.Inventors: Larry D. Partain, Stavros Prionas, Edward Seppi, Robert Sutherland, David Humber, Hassan Mostafavi, Felix Fernando, John Boone
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Publication number: 20080110968Abstract: A carton with a new dispenser that can be opened by a pull tab with this dispenser flap being placed in a corner of the top panel of the carton so that it is adjacent to the tops of the small necks of the bottles for easy opening and removal or for opening and reclosing. The dispenser flap is held in position by resistant tear lines but can be easily removed by an attached pull tab that is loosely connected to the top panel.Type: ApplicationFiled: January 8, 2008Publication date: May 15, 2008Inventors: Robert Sutherland, Raymond Spivey, Glen Harrelson
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Publication number: 20070295796Abstract: A carton can be placed in a dispensing configuration by separating the carton into dispenser sections. The dispenser sections may be connected by a hinge that allows the sections to stand side-by-side.Type: ApplicationFiled: June 25, 2007Publication date: December 27, 2007Inventors: Robert Sutherland, Charles Ho Fung, Barry Biddle
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Publication number: 20070269000Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.Type: ApplicationFiled: May 18, 2006Publication date: November 22, 2007Inventors: Larry Partain, Stavros Prionas, Edward Seppi, Robert Sutherland, David Humber, Hassan Mostafavi, Felix Fernando, John Boone
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Publication number: 20070178458Abstract: The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expresson of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific cancer sub-type. The ovarian cancer-associated genes and proteins of the invention are specifically exemplified by the genes and proteins set forth in Tables 1 to 5 and the Sequence Listing.Type: ApplicationFiled: September 5, 2003Publication date: August 2, 2007Inventors: Philippa O'Brien, Robert Sutherland, Susan Henshall
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Publication number: 20070099197Abstract: The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.Type: ApplicationFiled: February 28, 2006Publication date: May 3, 2007Inventors: Daniel Afar, Susan Henshall, Jordan Hiller, David Mack, Robert Sutherland
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Publication number: 20070080084Abstract: A package is formed from a carton and containers extending through a bottom panel of the carton. Engaged upper and lower strut pairs and brace apertures in the carton sidewalls provide support for the containers accommodated within the carton.Type: ApplicationFiled: October 6, 2006Publication date: April 12, 2007Inventor: Robert Sutherland
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Publication number: 20070080199Abstract: A carton with bevel corners for carrying cans, or other articles, which has an interlocking separator pad so the cans or articles can be contained in two layers is provided. The carton has two ends, each of which is closed by two side end closures and top and bottom end flaps. Each side end closure has an aperture that is interlocked with the end portion of an interlocking separator pad. In one embodiment of this invention, the interlocking separator pad has two tabs with the aperture in each side end closure being a slot through which a tab is extended. This pad may have a foldably attached leading flap that is lodged between cans or articles contained in the carton and the side end closures.Type: ApplicationFiled: December 8, 2006Publication date: April 12, 2007Applicant: Graphic Packaging International, Inc.Inventor: Robert Sutherland
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Publication number: 20070076935Abstract: A method and system for monitoring breathing movement of a subject is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.Type: ApplicationFiled: October 14, 2006Publication date: April 5, 2007Inventors: Andrew Jeung, Hassan Mostafavi, Majid Riaziat, Robert Sutherland, George Zdasiuk
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Publication number: 20070054268Abstract: The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expression of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific scanner sub-type. The ovarian cancer-associated genes and proteins of the invention are specifically exemplified by the genes and proteins set forth in Tables 1 to 3 and the Sequence Listing.Type: ApplicationFiled: September 5, 2003Publication date: March 8, 2007Inventors: Robert Sutherland, Susan Henshall, Philippa O'Brien