Abstract: A genomic test processing system and method employ an order management engine and one or more order processing engines, the order processing engines including a receiving engine, an execution engine, and a broadcasting engine. The receiving engine receives a state of an order from the order management engine. The execution engine determines a sequence of steps to advance the received state of an order to a final state, iteratively designates each step of the sequence of steps as completed before initiating the next step of the sequence of steps, and advances the state of the order to a final state when a last step of the sequence of steps is completed. The broadcasting engine broadcasts the final state of the order to the order management engine. The order management engine causes one of the order processing engines to generate a next-generation sequencing report from the final state of the order.

Abstract: Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.

Abstract: The present invention relates to a remote control assembly including a control unit and a toy vehicle. The control unit includes a series of control unit directional indicia to indicate the direction the vehicle will travel when an associated actuator on the control unit is engaged. The toy vehicle, furthermore, includes vehicle directional indicia, each vehicle indicium corresponding to an indicium on the control unit. As a result, the assembly includes a pair of matching indicia—one on the control unit and one on the toy vehicle—that indicates to a child the direction in which a vehicle will travel when an associated actuator on the control unit is engaged.

Abstract: The present invention discloses a play implement positioning device including an implement support for holding a first play implement in a play position to be struck. The invention also discloses a mechanism for selectively, automatically placing multiple stored play implements onto the implement support after the first implement has been struck and dislodged from the implement support.

Abstract: The present invention discloses a play implement positioning device including an implement support for holding a first play implement in a play position to be struck. The invention also discloses a mechanism for selectively, automatically placing multiple stored play implements onto the implement support after the first implement has been struck and dislodged from the implement support.

Abstract: The present invention discloses a play implement positioning device including an implement support for holding a first play implement in a play position to be struck. The invention also discloses a mechanism for selectively, automatically placing multiple stored play implements onto the implement support after the first implement has been struck and dislodged from the implement support.

Abstract: The present invention discloses a play implement positioning device including an implement support for holding a first play implement in a play position to be struck. The invention also discloses a mechanism for selectively, automatically placing multiple stored play implements onto the implement support after the first implement has been struck and dislodged from the implement support.

Abstract: An apparatus and a method for producing an animation effect are disclosed. The apparatus comprises at least one light reflecting member, a first light source, a second light source, and means to intermittently activate the first and second light sources to produce an animation effect.

Abstract: An apparatus and a method for producing an animation effect are disclosed. The apparatus comprises at least one light reflecting member, a first light source, a second light source, and means to intermittently activate the first and second light sources to produce an animation effect.

Abstract: An apparatus and a method for producing an animation effect are disclosed. The apparatus comprises a first light reflecting member, a second light reflecting member, a first light source, a second light source, and means to intermittently activate the first and second light sources to produce an animation effect. The first light reflecting member comprises a first surface and a second surface, wherein the light from the first light source enters the first member through the first surface and exits the first member through the second surface. The second light reflecting member comprises a first surface and a second surface, wherein the light from the second source enters the second member through the first surface and exits the second member through the second surface.

Abstract: An apparatus and a method for producing an animation effect are disclosed. The apparatus comprises a first light reflecting member, a second light reflecting member, a first light source, a second light source, and means to intermittently activate the first and second light sources to produce an animation effect. The first light reflecting member comprises a first surface and a second surface, wherein the light from the first light source enters the first member through the first surface and exits the first member through the second surface. The second light reflecting member comprises a first surface and a second surface, wherein the light from the second source enters the second member through the first surface and exits the second member through the second surface.

Abstract: A child's toy is provided which is convertible between an infant's gym and a toddler's piano. In the infant configuration, a small child can be placed under or seated in front of the toy within reach of hanging shapes. When the infant moves the hanging shapes, a sensory output of music and lights is produced through audio speakers and lighted keys. The infant's gym can be converted into a toddler configuration, which has keys arranged on top, resembling a piano. A toddler standing in front of the piano can produce a sensory output of music and lights by pressing the keys. A mode switch can be adjusted to vary the duration of the sensory output.

Abstract: A child's toy is provided which is convertible between an infant's gym and a toddler's piano. In the infant configuration, a small child can be placed under or seated in front of the toy within reach of hanging shapes. When the infant moves the hanging shapes, a sensory output of music and lights is produced through audio speakers and lighted keys. The infant's gym can be converted into a toddler configuration, which has keys arranged on top, resembling a piano. A toddler standing in front of the piano can produce a sensory output of music and lights by pressing the keys. A mode switch can be adjusted to vary the duration of the sensory output.

Abstract: The invention relates to a recharging or reloading bead incorporating discontinuous fibres or at least one reinforcing wire.This bead comprises a core reinforced by discontinuous fibres or at least one continuous wire (6) made from a non-fragile material, which melts or burns at a temperature equal to or above 500.degree. C., e.g. a weldable alloy or metal, such as copper or stainless steel. It also comprises an outer sheath (9b) made from an organic substance.It can be produced by the co-extrusion or co-spinning of two pastes.

Abstract: Method and apparatus for spectroscopic measurement of the concentration of a gas in a sample where you detect the intensity of light from a light source (1) passed through the sample (4) and through a reference cell (5) and generates a signal which represents the concentration of the gas. A laser diode (1) constitutes the light source which is locked to the absorption line of the gas at known concentration and pressure contained in a reference cell (5). The laser light with the properly selected wavelength is distributed via optical fibres (2, 3, 6) and/or glass prisms (19, 20) to the reference cell (5) and the sample (4). Non-gas-related transmission variations in the measurement path or in the optics is automatically compensated for by a special laser modulation which generates a time multiplexed reference.