Abstract: A method includes: obtaining an ultrasound image of an anatomical area from an ultrasound imaging device; inputting the ultrasound image into a first stage of a convolutional neural network, the first stage configured to determine key-point locations of the anatomical area; generating, for each of the key-point locations, a cropped region of the ultrasound image; inputting each of the cropped regions into a second stage of the convolutional neural network, the second stage configured to locate an anatomical landmark of the anatomical area; and outputting a location of the anatomical landmark.

Abstract: The invention refers to an anti-oxMIF/anti-CD3 antibody comprising at least one binding site specifically recognizing oxMIF and one binding site specifically recognizing CD3, which is an IgG wherein a scFv is fused to only one of the two heavy IgG chains, an IgG wherein one Fab arm is replaced by a bispecific-T-cell-engager (BiTE), or an IgG wherein both Fab arms are replaced by scFvs with different binding specificities, and its use in the treatment of hyperproliferative diseases, specifically in the treatment of cancer.

Abstract: The invention refers to an anti-ox MIF/anti-CD3 antibody comprising at least one binding site specifically recognizing ox MIF and at least one binding site specifically recognizing CD3 and its use in the treatment of hyperproliferative diseases, specifically in the treatment of cancers.

Abstract: A one-way valve (10) is disclosed which comprises a body portion (12) defining a passage through which fluid is able to pass during use, a support member (22) disposed in the passage, a seat member (28) disposed in the passage and provided with at least one aperture (32), a shaft (24) extending between the support member (22) and the seat member (28) and a membrane (26) disposed on the shaft (24) such that the membrane (26) is rotatable relative to the shaft (24). The seat member (28) cooperates with the membrane (26) such that a first predetermined pressure differential across the membrane (26) causes the membrane to cover the at least one aperture (32) and thereby prevent fluid flow past the seat member (28), and such that a second predetermined pressure differential of opposite polarity to the first predetermined pressure differential causes the membrane (26) to not cover the at least one aperture (32) and thereby permit fluid flow past the seat member (28).

Abstract: A fluid absorbing apparatus. The fluid absorbing apparatus includes an absorbing layer having a fluid absorbing material and a protective layer having a number of apertures extending through the protective layer and in fluid communication with the absorbing layer.