Patents by Inventor Robert Thomas Buckler

Robert Thomas Buckler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl-substituted triazolyl propionic acids
    Patent number: 4109001
    Abstract: Aryl-substituted-1,2,4-triazolyl propionic acid compounds, possessing antiinflammatory activity are disclosed. The compounds include: 3-[3-phenyl-1,2,4,(1H)-triazol-5-yl] propionic acid monohydrate; 3-[1-(3-chloro) phenyl and 3-[1-(3,5-dichloro)-phenyl-1,2,4,(1H)-triazol-3-yl] propionic acid; 3-[3-phenyl, 3-[3-(3-bromo)phenyl, 3-[3-(3-chloro)phenyl, and 3-[3-(4-methyl)-phenyl-1,2,4,(1H)-triazol-1-yl] propionic acid.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: August 22, 1978
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert Thomas Buckler, Elva Kurchacova
  • 5,6-Benza analogues of prostaglandin F
    Patent number: 4100353
    Abstract: Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano;M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene;L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine;J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine;W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl;T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; orT.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 to 6 carbon atoms.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: July 11, 1978
    Assignee: Miles Laboratories, Inc.
    Inventor: Robert Thomas Buckler
  • Cyclohexanone-5,6-benzo analogues of prostaglandin
    Patent number: 4100352
    Abstract: Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano;M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene;L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine;J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine;W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl;T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl;Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: July 11, 1978
    Assignee: Miles Laboratories, Inc.
    Inventor: Robert Thomas Buckler
  • Cyclohexanone 5,6-benzo analogues of prostaglandin E
    Patent number: 4100185
    Abstract: Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano;M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymetylene;L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine;J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine;W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl;T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl;Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: July 11, 1978
    Assignee: Miles Laboratories, Inc.
    Inventor: Robert Thomas Buckler
  • 5,6-Benzo analogues of prostaglandin E
    Patent number: 4097516
    Abstract: Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano;M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene;L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine;J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine;W is selected from the group consisting of --CH.sub.2 --CH-- or trans --CH.dbd.C--;T.sub.1 and T.sub.2 are attached to adjacent carbon atoms;T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl;T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl;Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: June 27, 1978
    Assignee: Miles Laboratories, Inc.
    Inventor: Robert Thomas Buckler
  • 5,6-Benzo analogues or prostaglandin E
    Patent number: 4096336
    Abstract: Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano;M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene;L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine;J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine;W is selected from the group consisting of --CH.sub.2 --CH-- or trans --CH.dbd.C--;T.sub.1 and T.sub.2 are attached to adjacent carbon atoms;T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl;T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl;Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: June 20, 1978
    Assignee: Miles Laboratories, Inc.
    Inventor: Robert Thomas Buckler
  • Phenyl- and (substituted)-phenyl-1,2,3-triazole-alkanoic and -alkenoic acids
    Patent number: 3985765
    Abstract: Certain phenyl- and (substituted)-phenyl-1,2,3-triazole-alkanoic and -alkenoic acids exhibit antiinflammatory or antipyretic activity.
    Type: Grant
    Filed: July 12, 1974
    Date of Patent: October 12, 1976
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert Thomas Buckler, Harold Eugene Hartzler, Shin Hayao
  • Phenyl- and (substituted)-phenyl-1,2,3-triazole-alkanoic and -alkenoic acids
    Patent number: 3948932
    Abstract: Certain phenyl- and (substituted)-phenyl-1,2,3-triazole-alkanoic and -alkenoic acids exhibit antiinflammatory or antipyretic activity.
    Type: Grant
    Filed: October 18, 1974
    Date of Patent: April 6, 1976
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert Thomas Buckler, Harold Eugene Hartzler, Shin Hayao, Gust Nichols
  • Phenyl-and (substituted)-phenyl-1,2,3-triazole-alkanoic and- alkenoic acids
    Patent number: 3948930
    Abstract: Certain phenyl- and (substituted)-phenyl-1,2,3-triazole-alkanoic and -alkenoic acids exhibit antiinflammatory or antipyretic activity.
    Type: Grant
    Filed: July 15, 1974
    Date of Patent: April 6, 1976
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert Thomas Buckler, Harold Eugene Hartzler, Shin Hayao, Gust Nichols
  • Phenyl-and (substituted)-phenyl-1,2,3-triazole-alkanoic and- alkenoic acids
    Patent number: 3948929
    Abstract: Certain phenyl- and (substituted)-phenyl-1,2,3-triazole-alkanoic and -alkenoic acids exhibit antiinflammatory or antipyretic activity.
    Type: Grant
    Filed: July 15, 1974
    Date of Patent: April 6, 1976
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert Thomas Buckler, Harold Eugene Hartzler, Shin Hayao, Gust Nichols