Abstract: Systems for producing a cosmetic effect in skin tissue of a patient are provided. The systems include a treatment module and an actuation assembly. The treatment module includes at least one coring element configured to remove a portion of skin tissue when the coring element is inserted into and withdrawn from the skin tissue. The actuation assembly is operably attached to the treatment module and can translate and/or actuate the treatment module in one or more directions relative to a surface of the skin tissue. The system can perform a microcoring procedure that provides a cosmetic effect to the patient. Methods of performing a microcoring procedure are also provided.

Abstract: This invention relates to treatment of cancer using a antibody drug conjugates that comprise PBD molecules in combination with FLT3 inhibitors.

Abstract: This invention relates to treatment of cancer using antibody drug conjugates that comprise PBD molecules in combination with Bcl-2 inhibitors.

Abstract: This invention relates to treatment of cancer using a antibody drug conjugates that comprise PBD molecules in combination with FLT3 inhibitors.

Abstract: A basketball includes a bladder, electronics within the bladder proximate an outer portion of the bladder, windings about the bladder, and a molded elastomeric layer about the bladder and extending over the electronics.

Abstract: This invention relates to treatment of cancer using antibody drug conjugates that comprise PBD molecules in combination with Bcl-2 inhibitors.

Abstract: A basketball includes a bladder, electronics within the bladder proximate an outer portion of the bladder, windings about the bladder, and a molded elastomeric layer about the bladder and extending over the electronics.

Abstract: A downhole impact generator (60) is adapted to be moved to a target location within a wellbore (68) for transmitting a jarring force to a well tool (72) positioned in the wellbore (68). The downhole impact generator (60) includes a downhole power unit (62) having a moveable shaft (66) and a jarring tool (64). The jarring tool (64) is operably engageable with the well tool (72) and is operably coupled with the moveable shaft (66) of the downhole power unit (62) such that when the jarring tool (64) is operably engaged with the well tool (72), linear movement of the moveable shaft (66) energizes the jarring tool (64) such that a jarring force can be transmitted by the jarring tool (64) to the well tool (72).

Abstract: System and method for analyzing routing in a system. Routing information for the system, received, e.g., from a user and/or tool, is analyzed, where the routing information specifies a plurality of routes in the system, and where each route comprises one or more routing resources in the system. A routing conflict between two routes of the plurality of routes is determined based on the analyzing, where the routing conflict is with respect to a routing resource comprised in each of the two routes, e.g., incompatible reservations and/or incompatible specified configuration of a routing resource included in each of the two routes. An error message useable in debugging routing for the system is output indicating the routing conflict, where the error message includes identification of the two routes, e.g., respective names, sources and destinations, and/or routing resource sequences, of the two routes, and may optionally include identification of the routing resource.

Abstract: A golf ball (20) in accordance with the principles of the present invention has a core (22) with a low compression, but has at least two additional layers (24, 26) that provide for increased durability and control. The core (22) is formed of a polybutadiene compound that produces a zero (or less) compression. The mantle (24) is molded around the core (22) using terpolymers, which are comprised of ethylene, acrylic acid and n-butyl acrylate, with 100% of the acrylic acid groups neutralized with metal ions. The mantle (24), when molded, yields a deflection of greater than 0.170 inches under an applied static load of 200 lb. This correlates to a PGA compression of between about ?20 and 15. The cover (26) is molded using conventional ionomers and “very low modulus” ionomers (V.L.M.I.), and has a hardness of between about 50 and 75 on a Shore D scale.