Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

Abstract: In one aspect, the present disclosure relates to a method of adaptive treatment of a subject with a tumor. The method may include administering a first pulse dose of radiation to a tumor within a subject; administering a second pulse dose of radiation to the tumor, wherein the second pulse dose is administered after an observation period, the observation period having a duration of at least 7 days; and concurrently treating the subject with an immunotherapy.

Abstract: Disclosed embodiments include systems and methods for archiving complete radiation records for transmission and review. In various embodiments, the radiation therapy archiving system miniaturizes some of the essential features of radiation therapy planning systems including radiation therapy data reading and writing capabilities, functionality for representing contoured objects and other radiation therapy specific features, and functionality for viewing radiation therapy plans. Compact radiation therapy datasets generated by the radiation therapy archiving system may accurately represent previous radiation doses administered to a patient. To help patients transition from one radiation therapy clinic to a remote clinic, radiation therapy datasets may be downloaded to a personal computer and transferred a remote treatment planning system to be used during the design phase of ongoing radiation therapy treatments.

Abstract: A system for MRI-guided radiotherapy is disclosed herein. The system includes a radiotherapy apparatus in the form of a linear accelerator or heavy ion system, an MRI portion, and a patient platform. The linear accelerator portion includes a stand, a gantry coupled to the stand, and a treatment head. The gantry is configured to rotate about the stand. The treatment head is coupled to the gantry. The treatment head is configured to deliver a radiotherapy beam. A system for MRI-guided radiotherapy is disclosed herein. The system includes a radiotherapy portion and an MRI portion adjacent to the radiotherapy portion. The MRI portion includes a magnet configured to generate an inhomogeneous magnetic field.

Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.

Abstract: A handheld diabetes management device having a database management system is disclosed. The device comprises a plurality of input modules, including a blood glucose reader, a user interface, a communications interface, and a continuous blood glucose input module. The input modules output data used to generate data records of different record types. The device further comprises N databases, each database having a different frequency range associated thereto, wherein the new record is stored in a particular database of the N databases based on the frequency range of the particular database and the frequency of the particular record type, and N is an integer greater than 1. The device further includes a database operation module that performs database operations on the N databases. The database management system provides increased reliability in the keeping of records on which medically important decisions are made.

Abstract: A handheld diabetes management device having a database management system is disclosed. The device comprises a plurality of input modules, including a blood glucose reader, a user interface, a communications interface, and a continuous blood glucose input module. The input modules output data used to generate data records of different record types. The device further comprises N databases, each database having a different frequency range associated thereto, wherein the new record is stored in a particular database of the N databases based on the frequency range of the particular database and the frequency of the particular record type, and N is an integer greater than 1. The device further includes a database operation module that performs database operations on the N databases. The database management system provides increased reliability in the keeping of records on which medically important decisions are made.

Abstract: The present disclosure describes a handheld diabetes management device that implements a failsafe firmware upgrading protocol to reduce required user interaction and risk of device downtime. The general processing module executes first software from nonvolatile memory. The general processing module receives second software from an external port and writes the second software to the nonvolatile memory. Based on an upgrade signal, the general processing module switches execution from the first software to the second software, evaluates proper operation of the general processing module, and switches execution back to the first software from the second software when proper operation of the general processing module using the second software is not detected. A communications module, in electrical communication with the general processing module, stores third software and executes the third software.

Abstract: A patient immobilization frame is provided that can be secured to a patient table in a radiation therapy facility. The frame includes fiducials integrated into the bottom panel of the frame. The frame is provided with a removable locking mechanism for locking the frame to the patient table. Each side walls of the frame defines a forward cut-out and a mid-side cut-out to accommodate larger girth patients. A panel insert is provided to close the mid-side cut-outs when the additional space is not required for the patient. The frame further includes an abdomen compression device supported by a cross bar that is movably mountable to the frame. The device includes a compression plate configured to contact the patient and a compression mechanism between the cross bar and the compression plate. A pressure transducer may be incorporated between the compression plate and the cross bar.

Abstract: A apparatus for monitoring and controlling a power system having an alternating current bus. The apparatus includes a module which is coupled to the bus and which digitizes and modulates at least one of a voltage waveform and a current waveform present on the bus. A control unit which is also coupled to the bus demodulates the digitized waveform and calculates a parameter selected from the group consisting of average current, root mean square current, peak current, current crest factor, average voltage, root mean square voltage, peak voltage, voltage crest factor, voltage surge, current waveform shape, voltage waveform shape, current waveform harmonic structure, voltage waveform harmonic structure and combinations thereof. The calculated parameter is used to monitor conditions on the bus and control loads connected to modules of the system.