Abstract: The present disclosure provides compositions comprising encapsulated engineered bacteria. The bacteria may be engineered to act as sensors of biomarkers, such as inflammation, as well as to produce diagnostic or therapeutic agents.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: A system and method for dispensing a first and second baking material where the baking materials are simultaneously dispensed through a discharge tube. The discharge tube is moved with respect to a male mold while dispensing the baking materials. An optional pressure foot follows the discharge tube and assists with joining the dispensed layer with the previous layer by applying pressure. The baking materials are dispensed and layered to form complex shapes not possible by pouring or application of a sheet of dough. The dough and mold are baked together and the baked item is removed from the mold after baking.

Abstract: A sterile drape assembly for a surgical system can comprise a sterile drape and a cinch assembly affixed to the sterile drape. A surgical support system can include a manipulator arm assembly comprising a first manipulator link extending between opposite ends; a drape guide lip extending from one end of the opposite ends of the first actively controlled manipulator link; and a second manipulator link coupled to the first manipulator link wherein the drape guide lip is a barrier between contact of a first drape portion covering the second manipulator link with a second drape portion covering the first manipulator link.

Abstract: There is provided a method of selecting a heater power setting for a non-combustible aerosol provision system. The method includes receiving user input at a user device indicative of a heater power setting, and transmitting, by the user device to the non-combustible aerosol provision system, an indication of the heater power setting. The method then includes setting, by the non-combustible aerosol provision system, a power level of the heater to the indicated heater power setting.

Abstract: A water purification apparatus capable of being cleaned at a point of care and methods for cleaning the water purification apparatus at the point of care are disclosed herein. The water purification apparatus and the methods provide an efficient use of a heater for heat disinfection the water purification apparatus. The water purification apparatus and the methods provide heat disinfection by recirculating heated fluid to further heat the fluid. Several different cleaning programs are provided that may be utilized for cleaning different parts of the water purification apparatus.

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

Abstract: There is provided a method to characterize a sorbent. The method may provide a sorbent, suspend the sorbent in a fluid, stir the sorbent in the fluid, filter the sorbent from the fluid to isolate a filtrate, measure the electrical conductivity of the filtrate, and measure the alkalinity of the filtrate.

Abstract: A medical device includes: one or more stimulation leads configured to stimulate at least a person's vagus nerve to treat, via the stimulation of the person's vagus nerve, both obesity and one or more medical conditions comorbid with the obesity; and a controller coupled to the one or more stimulation leads and configured to control and drive the stimulation provided by the one or more stimulation leads.

Abstract: A fire protection sprinkler including a frame body having an inlet, an outlet, defining an internal passageway extending between the inlet and the outlet along a sprinkler axis. A dome shaped deflector member is centered, axially aligned with the sprinkler axis, and spaced from the outlet. The deflector member has an outer surface and an inner surface that preferably includes: a peripheral region, a central region and an intermediate region. The intermediate region includes a primary deflecting surface, and a secondary deflecting surface that is surrounded by the primary deflecting surface. The deflector member provides for generation of a non-circular spray pattern defined by four zones of fluid density concentrically formed about the sprinkler axis.

Abstract: Disclosed herein are substituted aminopyrimidine compounds of formula I: and pharmaceutically acceptable salts thereof, wherein Ar, R1, and R2 have the meanings described herein; pharmaceutical compositions that include such compounds, and methods of using such compounds.

Abstract: Aspects of the subject disclosure may include, for example, determining a first virtual location of a first avatar of a first user within a virtual environment, determining a second virtual location a second avatar of a second user within the virtual environment that is in proximity to the first virtual location, and determining that the second user has an untrusted relationship with the first user. Further embodiments include presenting on a user interface of a first communication device of the first user a group of actions for restricting personal identifiable (PI) data of the first user presented by the first avatar in the virtual environment to the second user, receiving a selection of a first action from the group of actions for restricting the PI data, and restricting presentation of the PI data in the virtual environment according to the first action. Other embodiments are disclosed.

Abstract: A method of fighting a fire, the method includes aerating a firefighting foam composition to form an aerated firefighting foam; administering the aerated firefighting foam to a fire or applying the aerated firefighting foam to a surface of a volatile flammable liquid; wherein: the firefighting foam composition includes a sugar component comprising a monosaccharide sugar, a sugar alcohol, or a combination thereof; a polysaccharide thickener; a surfactant component comprising an anionic surfactant, a zwitterionic surfactant or a mixture of any two or more thereof; a water-miscible organic solvent; and at least about 30 wt. % water.

Abstract: Methods related generally to the removal of atmospheric pollutants from the gas phase, are provided. The methods involve contacting a first stream comprising NO and/or NO2 with a second stream comprising (ClO2)0 to provide a third stream comprising NO and NO2 at a molar ratio of about 1:1; and contacting the third stream with a fourth stream comprising an aqueous metal hydroxide (MOH) solution to convert NO and NO2 to MNO2.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft having a proximal end and a distal end, the tubular shaft extending along a longitudinal axis. The medical probe further comprises an expandable basket assembly coupled to the distal end of the tubular shaft. The basket assembly includes a plurality of electrodes with each electrode of the plurality of electrodes having a lumen therethrough. The basket assembly further includes a plurality of spines extending along the longitudinal axis and configured to bow radially outward from the longitudinal axis when the expandable basket assembly is transitioned from a collapsed form to an expanded form. Each spine includes a proximal and a distal end and a strut passing through the lumen of an electrode. The strut includes a mechanical retainer disposed on the strut to prevent the electrode from sliding proximally or distally along a length of the spine.

Abstract: An impeller for a pump for conveying wastewater is proposed, includes a shroud to be rotated about an axis of rotation defining an axial direction, and a blade to convey the wastewater. The blade includes a leading edge, a trailing edge, a pressure side, a suction side and an upper rim. The blade extends from the shroud in the axial direction to the upper rim and extends in a circumferential direction from the leading edge to the trailing edge. The suction side is the radially inner surface of the blade and the pressure side is the radially outer surface of the blade. The blade includes a closed passage extending inside the blade. The passage has an inlet at the pressure side and an outlet at the suction side of the blade.

Abstract: An example embodiment involves generating tumor image tiles from images of human papillomavirus positive (HPV +) head and neck squamous cell carcinoma (HNSCC) tumors, wherein the tumor image files are respectively labelled with indicators of tumor recurrence. The example embodiment may further involve training a neural network with the tumor image files as labelled. wherein the training results in the neural network learning combinations of histology features characteristic of tumor recurrence. Further steps may involve providing further tumor image tiles to the trained neural network. the neural network generating classifications of the further tumor image tiles based on likelihood of tumor recurrence. and storing the classifications with as respectively associated with the further tumor image tiles.

Abstract: Shop floor service equipment includes a battery and a control panel for electro-mechanically or electro-hydraulically controlling lifting mechanisms to raise and lower a vehicle or parts of vehicles for servicing without exposure to an undercarriage of the vehicle to replace the battery or to operate the control panel.

Abstract: Processes and apparatuses for converting PFAS. PFAS are heated and introduced to a reactant which will convert the PFAS. The PFAS may be in a stream that is a PFAS enriched stream formed by desorbing the PFAS from an adsorbent which removed the PFAS from a contaminant stream. An effluent from the PFAS conversion reaction is treated in a treatment zone and a treated effluent may be released to the atmosphere.

Abstract: A water gas shift (WGS) reactor system includes a housing; a reaction tube disposed in the housing, wherein a reaction channel is defined within the reaction tube and a cooling fluid channel is defined between the housing and the reaction tube; a catalyst disposed in the reaction channel, the catalyst configured to catalyze a hydrogen generation reaction; and a heat transfer material disposed in the reaction channel.