Abstract: Antibody conjugates of immune-modulatory compounds and pharmaceutical compositions for use in the treatment of disease, such as fibrotic diseases, autoimmune, or autoinflammatory diseases, are disclosed herein. The disclosed conjugates are useful, among other things, in treating fibrotic diseases, autoimmune diseases, or autoinflammatory diseases, such as by modulating TGF?R1, TGF?R2, TNKS, TNIK, or mTOR.

Abstract: A computer system is provided that includes a matching engine and a freezing process. The matching engine freezes one side of a two-sided data structure when an order is determined to matchable. The freezing process starts a timer based on the matching determination. Orders that are handled by the matching engine while the side is frozen are added to a queue. When the timer ends, the orders in the queue are processed against those orders that are now resting within the data structure.

Abstract: A component adapted to form a portion of a frame (e.g., a sill), door, trim piece, or the like. The component having a body comprised of at least one interior hollow portion that forms an opening at a first end of body, wherein the at least one interior hollow portion has a closed end such that water is prevented from traveling from a second end through the at least one interior hollow portion to the first end. A related method of manufacturing the component such as by injection molding, 3D printing, or multi-step extrusion is also provided.

Abstract: A battery pack (1) includes a housing (2) and an array (40) of electrochemical cells (80) disposed in the housing (2). The housing (2) includes a container (3) and a lid (30) that closes an open end of the container (3). The container (3) has a base (4), a sidewall (8) that surrounds the base (4), and a spring plate (110) disposed inside the side wall (8) between the cells (80) and the sidewall (8). The spring plate (110) is free standing within the container (3) and applies a spring force to the cell array (40) that restrains the cells (80) along an axis normal to the surface of the spring plates (110). The lid (30) includes inwardly-protruding pins (50, 60) that further restrain the cells (80) within the housing (2).

Abstract: A liquid hydrocarbon marine fuel oil includes a marine distillate fuel or a heavy oil or a blend thereof containing an additive combination including: (A) a polyalkenyl-substituted carboxylic acid or anhydride, and (B) a metal hydrocarbyl-substituted hydroxybenzoate and/or sulfonate detergent, where the mass:mass ratio of (A) to (B) is in the range of 20:1 to 1:20 and the treat rate of the additive combination is in the range of 5 to 10000 ppm by mass.

Abstract: The present invention relates to pharmaceutical compositions comprising a 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol compound or a pharmaceutically acceptable salt thereof, and to the use thereof for treating, preventing or delaying the progression of multiple sclerosis in a paediatric patient or a patient suffering from a specific condition.

Abstract: A method of notifying an owner of a fault associated with a vehicle system of a vehicle. The method includes receiving, at a computing processor, one or more fault messages from a vehicle system of the vehicle. Each fault message includes a fault source identifying the vehicle system, a fault time identifying a time of the fault, and a fault description. The method also includes determining, by the computing processor, a fault value associated with the received one or more fault messages. The fault value indicative of a period of time or a number of events from an initial received fault message. The method also includes transmitting, from the computing processor to a third party in communication with the computing processor, the fault value. The method also includes receiving, from the third party, a service notification, and displaying, on a display in communication with the computing processor, the service notification.

Abstract: Computer implemented systems and methods are provided for an automatic teller machine. In some embodiments, an automatic teller machine may comprise a display, a physical barrier configured to intersect a line of sight from a location adjacent the automatic teller machine to the display, one or more memory devices storing instructions, and one or more processors. The one or more processors may be configured to determine that a user is operating the automatic teller machine. The one or more processors may be further configured to alter a degree of opacity of the physical barrier, based on the determining.

Abstract: A padding machine for moving along a side of a ditch, scooping up excavated material from the side of the ditch, and sifting the excavated material into padding material for falling in the ditch comprises a frame comprising side frame members and frame rails spaced apart from the side frame members. A screening belt is driven around pulleys supported by the frame. The screening belt comprises a screen for collecting and conveying the excavated material upwardly. The screen comprises apertures for sifting the excavated material into padding material by permitting the padding material to fall through the apertures of the screen. The screen runs over the frame rails which support the screen. A discharge conveyor is mounted to the frame beneath an upper run of the screening belt. The discharge conveyor receives the padding material passing through the screen and discharges the padding material into the ditch.

Abstract: A transmit resonator is provided. The transmit resonator comprises: at least two inductors; at least one switching network electrically connected to one inductor of the at least two inductors; at least one secondary capacitive electrode electrically connected to the switching network; at least one main capacitive electrode electrically connected to one inductor of the at least two inductors; and a controller electrically connected to the switching network. The controller is configured to control the switching network to control connection of the secondary capacitive electrode to one inductor of the at least two inductors via the switching network. The inductors and electrodes are configured to resonate to generate an electric field.

Abstract: An apparatus for positioning micro-devices on a destination substrate includes a first support to hold a destination substrate, a second support to provide or hold a transfer body having a surface to receive an adhesive layer, a light source to generate a light beam, a mirror configured to adjustably position the light beam on the adhesive layer on the transfer body, and a controller. The controller is configured to cause the light source to generate the light beam and adjust the mirror to position the light beam on the adhesive layer so as to selectively expose one or more portions of the adhesive layer to create one or more neutralized portions. The transfer body and the destination substrate are moved away from each other and one or more micro-devices corresponding to the one or more neutralized portions of the adhesive layer remain on the destination substrate.

Abstract: An assembly for an aircraft having a radome configured to be integrated into an upper vertical stabilizer, a first and second reflector positioned within an inner cross-sectional width of the radome, and an antenna positioning system. The first and second reflectors each respectively have a first and second surface area and each are respectively coupled to a first and second telescoping arm configured to move in a vertical direction. Each reflector is configured to focus radio waves. The antenna positioning system is configured to: (i) rotate the first and second reflectors about respective vertical axes and (ii) raise the first antenna reflector to a first antenna position while lowering the second antenna reflector to a second antenna position such that the second antenna reflector avoids shading the first antenna reflector from the radio waves.

Abstract: A system and method are provided whereby a consumer is provided with nonpublic hotel rate accommodations for specifically identified hotels. In particular, a consumer provides a query as to whether a non-public rate exists for an accommodation at a specific hotel or property.

Abstract: A switchable stabilizer assembly of a vehicle, in particular for roll stabilization. The stabilizer assembly includes a first stabilizer half and a second stabilizer half, both coupled to a wheel of the vehicle, where the first and second stabilizer halves are coupled rotatably relative to each other about their longitudinal axis by a hydraulic actuator. The actuator has at least two working chambers filled with a hydraulic medium and has at least one fluid-conducting connection of variable flow cross section between the at least two working chambers. The working chambers are not elastically deformable. Instead, a spring element is arranged in the at least two working chambers and/or in at least two further working chambers of the actuator and is supported between a rotor and a stator of the actuator. The flow cross section of the fluid-conducting connection can be varied depending on the vibration frequency of the stabilizer assembly.

Abstract: A redundant steering system for watercraft that transfers rudder control to an electronic steering system when a hydraulic steering system either fails or is under repair. The electronic steering system utilizes either a fueled generator or a battery or series of batteries to power electric steering and flanking motors that serve control the angular position of the rudders.

Abstract: An anchor for connecting a concrete layer of a floor to a cellulosic layer of the floor, the cellulosic layer comprising a plurality of cellulosic members joined together in a side-by-side arrangement, the anchor including a first portion to extend between two adjacent cellulosic members of the cellulosic layer into the concrete layer of the floor. The first portion includes attachment structure to attach the first portion to one of the two adjacent cellulosic members of the cellulosic layer to attach the anchor to the cellulosic layer. An upper edge margin of the first portion is disposed within the concrete layer when the first portion is attached to the cellulosic layer. A second portion extends from the upper edge margin in a first direction that is transverse to the first portion. The second portion is spaced apart from the cellulosic layer and embedded within the concrete layer of the floor to attach the anchor to the concrete layer.

Abstract: A closure panel latch assembly can include an overslam bumper mechanism comprising a biasing element as a spring formed from a metallic material positioned relative to a slot of the latch assembly. The biasing element resists entry of a striker into the slot beyond a selected position in order to inhibit contact of the striker with a bottom end of the slot. Also provided is a closure panel latch assembly configured with the biasing element as a resilient element positioned relative to the slot of the latch assembly; The biasing element is coupled to the striker engagement member, such that the striker engagement member is positioned to engage the striker and resist travel of the striker towards the bottom end, wherein the biasing element controls the resistance to movement of the striker engagement member by the striker.

Abstract: The application relates to a catheter device with a distal bearing for bearing a distal end of a drive shaft. The distal bearing comprises a heat conducting part for enabling heat transfer away from the distal bearing and/or a spiral sleeve for receiving the distant end of the drive shaft.

Abstract: A mouth guard senses impact forces and determines if the forces exceed an impact threshold. If so, the mouth guard notifies the user of the risk for injury by haptic feedback, vibratory feedback, and/or audible feedback. The mouth guard system may also remotely communicate the status of risk and the potential injury. The mouth guard uses a local memory device to store impact thresholds based on personal biometric information obtained from the user and compares the sensed forces relative to those threshold values. The mouth guard and its electrical components on the printed circuit board are custom manufactured for the user such that the mouth guard provides a comfortable and reliable fit, while ensuring exceptional performance.

Abstract: A formulation comprising at least one ketogenic agent, at least one cannabinoid, at least one polyphenol, at least one phytonutrient, at least one dietary nutrient, at least one antioxidant, and at least one mineral, and mixtures and combinations thereof utilized for performance, cardiometabolic, cognitive, and women's health and wellness.