Patents by Inventor Robert Tofe

Robert Tofe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Micronized compositions composed of bone grafts and methods of making and using the same
    Patent number: 12290613
    Abstract: Described herein are compositions composed of micronized particles derived from one or more components present in placental tissue in combination with one or more bone grafts. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: May 6, 2025
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, Robert Tofe
  • Reinforced placental tissue grafts and methods of making and using the same
    Patent number: 12208180
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: January 28, 2025
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Robert Tofe, Elizabeth Chen
  • Micronized placental tissue compositions and methods of making and using the same
    Patent number: 11931384
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 19, 2024
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME
    Publication number: 20230414670
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Application
    Filed: September 11, 2023
    Publication date: December 28, 2023
    Applicant: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • DE-EPITHELIALIZED PLACENTAL TISSUE GRAFTS AND METHODS OF PREPARING AND USING THE SAME
    Publication number: 20230390457
    Abstract: The present disclosure relates to compositions and methods for obtaining a modified amnion, a spongy intermediate layer, and a chorion from a placental membrane tissue by removing the amniotic epithelium layer to achieve a modified amnion wherein the modified amnion does not contain an amniotic epithelium layer and wherein the spongy intermediate layer is disposed between the modified amnion and the chorion.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicant: SNOASIS MEDICAL LLC
    Inventors: Robert TOFE, Peter MARINER
  • Placental tissue grafts and improved methods of preparing and using the same
    Patent number: 11752174
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: September 12, 2023
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Laminated tissue grafts composed of Wharton's jelly and methods of making and using the same
    Patent number: 11602549
    Abstract: Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 14, 2023
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, John Daniel, Robert Tofe
  • MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220125855
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Application
    Filed: January 10, 2022
    Publication date: April 28, 2022
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220105138
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Micronized placental tissue compositions and methods of making and using the same
    Patent number: 11235007
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: February 1, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Micronized placental tissue compositions and methods of making and using the same
    Patent number: 11219647
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: January 11, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Micronized placental tissue compositions and methods of making and using the same
    Patent number: 11103536
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: August 31, 2021
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • REINFORCED PLACENTAL TISSUE GRAFTS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20210146011
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Application
    Filed: December 4, 2020
    Publication date: May 20, 2021
    Inventors: Thomas J. Koob, Robert Tofe, Elizabeth Chen
  • Placental Tissue Grafts And Improved Methods Of Preparing And Using The Same
    Publication number: 20210093672
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Application
    Filed: December 14, 2020
    Publication date: April 1, 2021
    Applicant: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Placental tissue grafts and improved methods of preparing and using the same
    Patent number: 10874697
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: December 29, 2020
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Reinforced placental tissue grafts and methods of making and using the same
    Patent number: 10857266
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: December 8, 2020
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Robert Tofe, Elizabeth Chen
  • MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190374584
    Abstract: Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Application
    Filed: July 24, 2019
    Publication date: December 12, 2019
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • LAMINATED TISSUE GRAFTS COMPOSED OF WHARTON'S JELLY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190307921
    Abstract: Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.
    Type: Application
    Filed: May 23, 2019
    Publication date: October 10, 2019
    Applicant: MiMedx Gruop, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, John Daniel, Robert Tofe
  • Micronized placental tissue compositions and methods of making and using the same
    Patent number: 10376546
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: August 13, 2019
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Laminated tissue grafts composed of Wharton's jelly and methods of making and using the same
    Patent number: 10350049
    Abstract: Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: July 16, 2019
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, John Daniel, Robert Tofe