Patents by Inventor Robert Toso

Robert Toso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-resin coupling apparatus and methods
    Patent number: 11969703
    Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: April 30, 2024
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Robert Toso, Richard Spanggord, Mei Tan, Van Taiariol, Yekaterina Lin
  • ANTIBODY-RESIN COUPLING APPARATUS AND METHODS
    Publication number: 20220105490
    Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.
    Type: Application
    Filed: September 16, 2021
    Publication date: April 7, 2022
    Inventors: Robert TOSO, Richard SPANGGORD, Mei TAN, Van TAIRIOL, Yekaterina LIN
  • Antibody-resin coupling apparatus and methods
    Patent number: 11123704
    Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 21, 2021
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Robert Toso, Richard Spanggord, Mei Tan, Van Tairiol, Yekaterina Lin
  • ANTIBODY-RESIN COUPLING APPARATUS AND METHODS
    Publication number: 20190039042
    Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.
    Type: Application
    Filed: July 30, 2018
    Publication date: February 7, 2019
    Inventors: Robert Toso, Richard Spanggord, Mei Tan, Van Tairiol, Yekaterina Lin
  • Methods of conditioning an affinity resin after storage
    Patent number: 6555391
    Abstract: This invention relates methods for conditioning affinity chromatography resins to decrease leaching of the ligand during purification. The methods involve incubating the resin in a buffered solution of a hydroxyalkylamine compound (e.g., ethanolamine) prior to use of the resin for an affinity purification. The treatment removes unstably bound ligand from the resin.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: April 29, 2003
    Assignee: Baxter International, Inc.
    Inventors: Susan L. Bernhard, Robert Toso, Van Taiariol