Patents by Inventor Robert Turkalj

Robert Turkalj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combined process for the purification of vancomycin hydrochloride
    Patent number: 5853720
    Abstract: The present invention discloses a new process for the purification of vancomycin hydrochloride by combining preparative chromatography on a silica gel column and the precipitation with ethanol from a salt-water-ethanolic solution without intermediary filtering, whereby the chromatographic purity of the product is improved.The chromatography is carried out on a column containing a silica gel stationary phase and an alkaline water-methanolic mobile phase at defined pH, mobile phase flow and temperature as well as the amount and concentration of vancomycin hydrochloride. The process is distinguished by the yield and chromatographic purity of the obtained product of about 93% area.Vancomycin hydrochloride purified according to the present invention is useful for peroral as well as parenteral administration since the portion of impurities it contains is for one third smaller than in hitherto available product.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: December 29, 1998
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
    Inventors: Zlatko Pflaum, Robert Turkalj