Patents by Inventor Robert U. Simpson

Robert U. Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for tranquilizing heart muscle
    Patent number: 10716798
    Abstract: A pharmaceutical composition for tranquilizing cardiomyocytes present in heart muscle in a subject diagnosed with a cardiac overload disease comprises a therapeutically effective amount of a Vitamin D5 compound and a pharmaceutically acceptable excipient. A method for treating or preventing heart failure in a subject diagnosed as having heart failure or being at risk for heart failure, comprises administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a Vitamin D5 compound and a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: July 21, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Robert U. Simpson
  • Amelioration of intestinal fibrosis and treatment of Crohn's disease
    Patent number: 9517241
    Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: December 13, 2016
    Assignee: The Regents Of The University Of Michigan
    Inventors: Robert U. Simpson, Peter D. R. Higgins, Laura A. Johnson
  • Amelioration of intestinal fibrosis and treatment of Crohn's disease
    Patent number: 9370527
    Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: June 21, 2016
    Assignee: The Regents Of The University Of Michigan
    Inventors: Robert U. Simpson, Peter D. R. Higgins, Laura A. Johnson
  • AMELIORATION OF INTESTINAL FIBROSIS AND TREATMENT OF CROHN'S DISEASE
    Publication number: 20160166587
    Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.
    Type: Application
    Filed: February 24, 2016
    Publication date: June 16, 2016
    Inventors: Robert U. Simpson, Peter D. R. Higgins, Laura A. Johnson
  • AMELIORATION OF INTESTINAL FIBROSIS AND TREATMENT OF CROHN'S DISEASE
    Publication number: 20140187521
    Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.
    Type: Application
    Filed: December 19, 2013
    Publication date: July 3, 2014
    Inventors: Robert U. Simpson, Peter D.R. Higgins, Laura A. Johnson
  • Screening Assays for Antagonists and Analyses of Cardiac Hypertrophy
    Publication number: 20100190187
    Abstract: Various embodiments of the present invention provide methods for screening for candidate heart failure compounds employing screening assays effective in identifying agonists or antagonists or ligands of vitamin D receptor mediated pathways implicated in heart failure. Methods are provided for the screening of test compounds that can specifically bind to the vitamin D receptor. Methods for screening for a test compound which modulates the activity of a VDR for the treatment of heart failure, wherein the method comprises: (a) contacting a test compound with VDR in a reaction mixture, wherein the reaction mixture conditions permits the test compound to bind to a VDR, including membrane VDR and nuclear VDR. The binding between the test compound and the VDR is compared to a reference such as Vitamin D3. The modulation of biomarkers after a test compound has bound and activated a VDR are also measured and compared to samples in the absence of test compound.
    Type: Application
    Filed: February 14, 2007
    Publication date: July 29, 2010
    Applicant: The Regents of the University of Michigan Office of Technology Transfer
    Inventors: Robert U. Simpson, Daniel Tishkoff, Karl Nibbelink
  • COMPOSITIONS AND METHODS FOR TRANQUILIZING HEART MUSCLE
    Publication number: 20090325910
    Abstract: A pharmaceutical composition for tranquilizing cardiomyocytes present in heart muscle in a subject diagnosed with a cardiac overload disease comprises a therapeutically effective amount of a Vitamin D5 compound and a pharmaceutically acceptable excipient. A method for treating or preventing heart failure in a subject diagnosed as having heart failure or being at risk for heart failure, comprises administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a Vitamin D5 compound and a pharmaceutically acceptable excipient.
    Type: Application
    Filed: February 21, 2008
    Publication date: December 31, 2009
    Applicant: The Regents of the University of Michigan
    Inventor: Robert U. Simpson